Motoneuron and muscle fiber succinate dehydrogenase activity in control and overloaded plantaris
Abstract
To determine the level of coordination in succinate dehydrogenase (SDH) activity between plantaris motoneurons and muscle fibers, the soleus and gastrocnemius muscles were bilaterally excised in four cats to subject the plantaris to functional overload (FO). Five normal cats served as controls. Twelve weeks after surgery the right plantaris in each cat was injected with horseradish peroxidase to identify plantaris motoneurons. SDH activity then was measured in a population of plantaris motoneurons and muscle fibers in each cat. Control motoneurons and muscle fibers had similar mean SDH activities and a similar relationship between cell size and SDH activity. After FO, muscle fiber size doubled and mean muscle fiber SDH activity halved. Motoneuron mean SDH activity and size were unaffected by FO. Total SDH activity was unchanged in both the motoneurons and muscle fibers after FO. These changes suggest a selective increase in contractile proteins with little or no modulation of mitochondrial proteins in the muscle fibers, because total SDH activity was unchanged in muscle fibers after FO. These data demonstrate that although mean SDH activities were similar in control motoneurons and muscle fibers, mean SDH activities in these two cell types can change independently.
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A feedback loop exists that conveys information about muscle activity and condition to motor neurons.
“This implies that a feedback loop exists that conveys information about muscle activity and the condition of the muscle to the motor neuron.”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [25]
Mitochondrial SDH activity increases in motor neurons after functional overload of the plantaris hindlimb muscle in cats.
“increases in mitochondrial succinate dehydrogenase (SDH) activity in motor neurons following functional overload of the plantaris hindlimb muscle in cats (25).”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [25]
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Self-citation
- Authors
- Chalmers, G. R., Roy, R. R., & Edgerton, V. R.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1991-10-01
- Volume
- 71
- Issue
- 4
- Pages
- 1589-1592
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2277703827
- Cited by
- 28
- References
- 0
- Citations by year
- 2025: 1 · 2021: 1 · 2017: 1 · 2016: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-16333, P01NS016333)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- succinate dehydrogenase, plantaris muscle, functional overload, motor neurons, muscle fiber size, mitochondrial proteins, contractile proteins, soleus muscle, gastrocnemius, muscle fiber hypertrophy, cats
- MeSH terms
- Animals, Cats, Female, Histocytochemistry, Horseradish Peroxidase, Mitochondria, Muscle, Motor Neurons, Muscles, Neuromuscular Junction, Oxidation-Reduction, Spinal Cord, Succinate Dehydrogenase
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