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Vagal function impairment after exercise training
Abstract
The present investigation was undertaken to evaluate the vagal function of trained (T) and sedentary (S) rats by use of different approaches in the same animal. After 13 wk of exercise training (treadmill for 1 h 5 times/wk at 26.8 m/min and 15% grade), T rats had a resting heart rate (HR) slightly but significantly lower than S rats (299 +/- 3 vs. 308 +/- 3 beats/min). T rats had marked reduction of the intrinsic HR (329 +/- 4 vs. 369 +/- 5 beats/min) after blockade by methylatropine and propranolol. They also exhibited depressed vagal and sympathetic tonus. Baroreflex bradycardia (phenylephrine injections) was reduced, bradycardic responses produced by electrical stimulation of the vagus were depressed, and responses to methacholine injection were decreased in T rats. Therefore several evidences of vagal function impairment were observed in T rats. The resting bradycardia after exercise training is more likely to be dependent on alterations of the pacemaker cells, inasmuch as the intrinsic HR was markedly reduced.
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Citations
Cited by
Krieger, E. M., Brum, P. C., & Negrão, C. E. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.720 · Cited by 306
Self-citationExercise training restores baroreflex sensitivity in never-treated hypertensive patients
Laterza, M. C., de Matos, L. D. N. J., Trombetta, I. C., Braga, A. M. W., Roveda, F., Alves, M. J. N. N., Krieger, E. M., Negrão, C. E., & Rondon, M. U. P. B. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.085548 · Cited by 299
Zou, L., Sasaki, J. E., Wei, G.-X., Huang, T., Yeung, A. S., Neto, O. B., Chen, K. W., & Hui, S. S.-C. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7110404 · Cited by 267
“Long-term participation in exercise training has been shown to induce a resting bradycardia accompanied by reduced sympathetic activity and/or elevated parasympathetic activity and a marked reduction in intrinsic heart rate [7].”
BackgroundAtrial fibrillation in highly trained endurance athletes — Description of a syndrome
Sanchis-Gomar, F., Perez-Quilis, C., Lippi, G., Cervellin, G., Leischik, R., Löllgen, H., Serrano-Ostáriz, E., & Lucia, A. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.10.047 · Cited by 95
Exercise training bradycardia is largely explained by reduced intrinsic heart rate
Bahrainy, S., Levy, W. C., Busey, J. M., Caldwell, J. H., & Stratton, J. R. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.07.203 · Cited by 57
Metadata
- Authors
- Negrao, C. E., Moreira, E. D., Santos, M. C., Farah, V. M., & Krieger, E. M.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1992-05-01
- Volume
- 72
- Issue
- 5
- Pages
- 1749-1753
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1862601124
- Cited by
- 165
- References
- 0
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Vagal function impairment after exercise training. https://app.cochat.ai/papers/10.1152/jappl.1992.72.5.1749
- The paper
- Negrao, C. E., Moreira, E. D., Santos, M. C., Farah, V. M., & Krieger, E. M. (1992). Vagal function impairment after exercise training. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1992.72.5.1749
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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