Exercise training restores baroreflex sensitivity in never-treated hypertensive patients

Laterza, Mateus C.; de Matos, Luciana D.N.J.; Trombetta, Ivani C.; Braga, Ana M.W.; Roveda, Fabiana; Alves, Maria J.N.N.; Krieger, Eduardo M.; Negrão, Carlos E.; Rondon, Maria U.P.B.

doi:10.1161/hypertensionaha.106.085548

Cited by 299Heart Rate Variability and Autonomic ControlCardiovascular and exercise physiologyBlood Pressure and Hypertension Studies

Exercise training restores baroreflex sensitivity in never-treated hypertensive patients

Laterza, Mateus C., de Matos, Luciana D.N.J., Trombetta, Ivani C., Braga, Ana M.W., Roveda, Fabiana, Alves, Maria J.N.N., Krieger, Eduardo M., Negrão, Carlos E. +1 more·2007·Hypertension

DOI 10.1161/hypertensionaha.106.085548

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Abstract

The effects of exercise training on baroreflex control of sympathetic nerve activity in human hypertension are unknown. We hypothesized that exercise training would improve baroreflex control of muscle sympathetic nerve activity (MSNA) and heart rate (HR) in patients with hypertension and that exercise training would reduce MSNA and blood pressure (BP) in hypertensive patients. Twenty never-treated hypertensive patients were randomly divided into 2 groups: exercise-trained (n=11; age: 46+/-2 years) and untrained (n=9; age: 42+/-2 years) patients. An age-matched normotensive exercise-trained group (n=12; age: 42+/-2 years) was also studied. Baroreflex control of MSNA (microneurography) and HR (ECG) was assessed by stepwise intravenous infusions of phenylephrine and sodium nitroprusside and analyzed by linear regression. BP was monitored on a beat-to-beat basis. Exercise training consisted of three 60-minute exercise sessions per week for 4 months. Under baseline conditions (before training), BP and MSNA were similar between hypertensive groups but significantly increased when compared with the normotensive group. Baroreflex control of MSNA and HR was similar between hypertensive groups but significantly decreased when compared with the normotensive group. In hypertensive patients, exercise training significantly reduced BP (P<0.01) and MSNA (P<0.01) levels and significantly increased baroreflex control of MSNA and HR during increases (P<0.01 and P<0.03, respectively) and decreases (P<0.01 and P<0.03, respectively) in BP. The baseline (preintervention) difference in baroreflex sensitivity between hypertensive patients and normotensive individuals was no longer observed after exercise training. No significant changes were found in untrained hypertensive patients. In conclusion, exercise training restores the baroreflex control of MSNA and HR in hypertensive patients. In addition, exercise training normalizes MSNA and decreases BP levels in these patients.

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Kataoka, Y., Kamijo, Y., Ogawa, Y., Sumiyoshi, E., Nakae, M., Ikegawa, S., Manabe, K., Morikawa, M., Nagata, M., Takasugi, S., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00033.2016 · Cited by 23 · see citing works
Comparison of Baroreflex Sensitivity and Cardiac Autonomic Function Between Adolescent Athlete and Non-athlete Boys – A Cross-Sectional Study
Subramanian, S. K., Sharma, V. K., Arunachalam, V., Rajendran, R., & Archana Gaur, T. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01043 · Cited by 24 · see citing works
Exercise training in patients with pulmonary and systemic hypertension: A unique therapy for two different diseases
Leggio, M., Fusco, A., Limongelli, G., & Sgorbini, L. (2017) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2017.09.010 · Cited by 22 · see citing works
Altered baroreflex sensitivity in young women with a family history of hypertension
Matthews, E. L., Sebzda, K. N., & Wenner, M. M. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00471.2018 · Cited by 22 · see citing works

Abstract 4150: Exercise Training Restores Baroreflex Control of Sympathetic Nerve Activity in Hypertensive Patients
Laterza, M. C., de Matos, L. D. N. J., Alves, M. J. J., Braga, A. M. F. W., Roveda, F., Trombetta, I. C., Krieger, E. M., Negrão, C. E., & Rondon, M. U. P. B. (2006) · Circulation
The effects of exercise training on baroreflex control of sympathetic nerve activity and heart rate in hypertensive patients
Laterza, M. C. (2007) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
The Effect of Physical Resistance Training on Baroreflex Sensitivity of Hypertensive Rats
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Exercise Training Increases Baroreceptor Gain Sensitivity in Normal and Hypertensive Rats
Brum, P. C., da Silva, G. J. J., Moreira, É. D., Ida, F., Negrão, C. E., & Krieger, E. M. (2000) · Hypertension · doi:10.1161/01.hyp.36.6.1018 · Cited by 190 · see citing works
Sympathetic activity is not a main cause of blood pressure reduction with exercise training in un‐medicated middle‐aged/older men
Ehlers, T. S., Møller, S., Hansen, C. C., Tamariz‐Ellemann, A., Vermeulen, T. D., Shoemaker, J. K., Gliemann, L., & Hellsten, Y. (2023) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14300 · Cited by 10 · see citing works

Authors: Laterza, M. C., de Matos, L. D. N. J., Trombetta, I. C., Braga, A. M. W., Roveda, F., Alves, M. J. N. N., Krieger, E. M., Negrão, C. E., & Rondon, M. U. P. B.
Affiliations: Universidade de São Paulo (BR)
From the Heart Institute (InCor) (M.C.L., L.D.N.J.d.M., I.C.T., A.M.W.B., F.R., M.J.N.N.A., E.M.K., C.E.N., M.U.P.B.R.), University of São Paulo Medical School, São Paulo, Brazil; and the School of Physical Education and Sports (C.E.N.), University of São Paulo, São Paulo, Brazil.
ORCID: Laterza, Mateus C.
Trombetta, Ivani C.
Roveda, Fabiana
Rondon, Maria U.P.B.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-06
Volume: 49
Issue: 6
Pages: 1298-1306
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.106.085548
OpenAlex: W2119216309
Cited by: 299
References: 64
Citations by year: 2026: 6 · 2025: 14 · 2024: 15 · 2023: 14 · 2022: 17 · 2021: 17 · 2020: 17 · 2019: 14 · 2018: 20 · 2017: 30 · 2016: 17 · 2015: 16 · 2014: 14 · 2013: 19 · 2012: 20
FWCI: 7.26
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: exercise training, baroreflex sensitivity, muscle sympathetic nerve activity, heart rate, blood pressure, autonomic nervous system, phenylephrine, sodium nitroprusside, microneurography
MeSH terms: Adult, Blood Pressure, Exercise Therapy, Female, Heart Rate, Humans, Hypertension, Male, Middle Aged, Sympathetic Nervous System, Linear Models, Baroreflex, Muscle, Skeletal

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Exercise training restores baroreflex sensitivity in never-treated hypertensive patients

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