Cited by 288Cardiovascular and exercise physiologyMuscle metabolism and nutritionAdvanced MRI Techniques and Applications

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Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles

McCully, K. K., Fielding, R. A., Evans, W. J., Leigh, J. S., Posner, J. D.·1993·Journal of Applied Physiology

DOI 10.1152/jappl.1993.75.2.813

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Abstract

This study compared in vivo measurements of muscle metabolism in humans with magnetic resonance spectroscopy (MRS) and in vitro analysis of biopsies. Healthy subjects [4 young males, 28.2 +/- 6.8 (SD) yr, and 6 older subjects (5 males, 1 female), 66 +/- 6.0 yr] performed a maximal cycle ergometer test, and MRS measurements of the calf muscles and needle biopsies of the lateral gastrocnemius were performed. Biopsies were analyzed for fiber type and citrate synthase (CS) activity. MRS measurements of inorganic phosphate (Pi), phosphocreatine (PCr), ATP, and pH were made using a 1.8-T 78-cm clear-bore magnet-and-spectrometer system. Two or three 5-min bouts of plantar flexion were performed against variable resistance to deplete PCr levels to 50% of resting values (mean end pH 6.99). PCr values during recovery were fit to an exponential curve, and the rate constant (PCrrate) was calculated. PCrrate was used as an index of oxidative metabolism. Older subjects had lower peak O2 uptake (VO2 peak) values (19.2 +/- 5.6 vs. 49.5 +/- 8.1 ml O2.min-1 x kg-1), CS activities (16 +/- 2.8 vs. 25 +/- 2.6 mmol.kg wet wt-1 x min-1), and PCrrate values (25.3 +/- 8. vs. 37.5 +/- 5.3 mmol PCr.kg wet wt-1.min-1) than young subjects. PCrrate correlated with CS activity, and both PCrrate and CS activity correlated with VO2 peak (P < 0.05). No correlations were found between percent fiber type and PCrrate, CS activity, and VO2 peak. These results support studies that showed decreases in muscle metabolism with age in healthy humans and show a good correlation between in vivo and in vitro measurements of oxidative metabolism.

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THE SPECIFICITY OF THE HISTOCHEMICAL METHOD FOR ADENOSINE TRIPHOSPHATAS
Padykula, H. A., & Herman, E. (1955) · Journal of Histochemistry & Cytochemistry · doi:10.1177/3.3.170 · Cited by 1,201
Guidelines for Exercise Testing and Prescription
Sharp, N. C. C. (1993) · British Journal of Sports Medicine · doi:10.1136/bjsm.27.2.138-a · Cited by 1,190
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
Trounce, I., Byrne, E., & Marzuki, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92143-0 · Cited by 730
The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man
Harris, R. C., Edwards, R. H. T., Hultman, E., Nordesj�, L. O., Nylind, B., & Sahlin, K. (1976) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00585149 · Cited by 527
Suction applied to a muscle biopsy maximizes sample size
Evans, W. J., Phinney, S. D., & Young, V. R. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198201000-00018 · Cited by 525
Self-citation
Cycling efficiency is related to the percentage of Type I muscle fibers
Coyle, E. F., Sidossis, L. S., Horowitz, J. F., & Beltz, J. D. (1992) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199207000-00008 · Cited by 524
A linear model of muscle respiration explains monoexponential phosphocreatine changes
Meyer, R. A. (1988) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1988.254.4.c548 · Cited by 514
Histochemical and enzymatic comparison of the gastrocnemius muscle of young and elderly men and women
Coggan, A. R., Spina, R. J., King, D. S., Rogers, M. A., Rogers, M. A., Brown, M., Nemeth, P. M., & Holloszy, J. O. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.3.b71 · Cited by 456
Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training
Davies, K. J. A., Packer, L., & Brooks, G. A. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90312-x · Cited by 430
Effects of gender, age, and fitness level on response of VO2max to training in 60-71 yr olds
Kohrt, W. M., Malley, M. T., Coggan, A. R., Spina, R. J., Ogawa, T., Ehsani, A. A., Bourey, R. E., Martin, W. H., & Holloszy, J. O. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.5.2004 · Cited by 383

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Mattei, J. P., Bendahan, D., Roussel, M., Fur, Y. L., & Cozzone, P. J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00503-7 · Cited by 20
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Johnson, P., Winter, E., Paterson, D. H., Koval, J. J., Nevill, A. M., & Cunningham, D. A. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.01933.x · Cited by 19
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Bortoli, S., Renault, V. M., Mariage, R., Eveno, E., Auffray, C., Butler-Browne, G. S., & Piétu, G. (2005) · Gene · doi:10.1016/j.gene.2004.12.029 · Cited by 16
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Consequences of Aging on Mitochondrial Respiratory Chain Enzymes in Cultured Human Fibroblasts Treated with Ascorbate
Sharma, P., Rupar, C. A., & Rip, J. W. (1998) · Gerontology · doi:10.1159/000021988 · Cited by 14
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Authors: McCully, K. K., Fielding, R. A., Evans, W. J., Leigh, J. S., & Posner, J. D.
Affiliations: Department of Medicine, Medical College of Pennsylvania, Philadelphia 19129.
ORCID: McCully, K. K.
Fielding, R. A.
Evans, W. J.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1993-08-01
Volume: 75
Issue: 2
Pages: 813-819
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1993.75.2.813
OpenAlex: W2273652180
Cited by: 288
References: 28
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 15 · 2013: 16 · 2012: 13
FWCI: 11.16
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ag003934-14)
National Institute on Aging (AG 03934)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: muscle metabolism, aging, oxidative metabolism, citrate synthase activity, triceps surae, lateral gastrocnemius, inorganic phosphate, muscle fiber type, peak oxygen uptake, plantar flexion, magnetic resonance spectroscopy, human skeletal muscle
MeSH terms: Adenosine Triphosphate, Adult, Aged, Aging, Citrate (si)-Synthase, Exercise Test, Female, Humans, Leg, Male, Middle Aged, Muscles, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Oxygen Consumption, Phosphates, Phosphocreatine, In Vitro Techniques

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Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles

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