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Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men
Abstract
Resting metabolic rate (RMR) decreases with age, largely because of an age-related decline in fat-free mass (FFM). We hypothesized that a strength-training program capable of eliciting increases in FFM would also increase RMR in older individuals. To test this hypothesis, RMR, body composition, and plasma concentrations of certain hormones known to affect RMR were measured before and after a 16-wk heavy-resistance strength-training program in 13 healthy men 50–65 yr of age. Average strength levels, assessed by the three-repetition maximum test, increased 40% with training (P < 0.001). Body weight did not change, but body fat decreased (25.6 +/- 1.5 vs. 23.7 +/- 1.7%; P < 0.001) and FFM increased (60.6 +/- 2.2 vs. 62.2 +/- 2.1 kg; P < 0.01). RMR, measured by indirect calorimetry, increased 7.7% with strength training (6,449 +/- 217 vs. 6,998 +/- 226 kJ/24 h; P < 0.01). This increase remained significant even when RMR was expressed per kilogram of FFM. Strength training increased arterialized plasma norepinephrine levels 36% (1.1 +/- 0.1 vs. 1.5 +/- 0.1 nmol/l; P < 0.01) but did not change fasting glucose, insulin, or thyroid hormone levels. These results indicate that a heavy-resistance strength-training program increases RMR in healthy older men, perhaps by increasing FFM and sympathetic nervous system activity.
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“Pratley et al. (21) found that resistance training in healthy older men increased BMR, and this was accompanied by an increase in FFM.”
From Concurrent resistance and endurance training influence basal metabolic rate in nondieting individuals (1998) · cites this paper as [21]
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Williams, M. A., Haskell, W. L., Ades, P. A., Amsterdam, E. A., Bittner, V., Franklin, B. A., Gulanick, M., Laing, S. T., & Stewart, K. J. (2007) · Circulation · doi:10.1161/circulationaha.107.185214 · Cited by 1,211
Resistance Exercise in Individuals With and Without Cardiovascular Disease
Pollock, M. L., Franklin, B. A., Balady, G. J., CHAITMAN, B. R., Fleg, J. L., Fletcher, B. J., Limacher, M. C., Piña, I. L., Stein, R. A., Williams, M. A., et al. (2000) · Circulation · doi:10.1161/01.cir.101.7.828 · Cited by 1,076
Resistance Training is Medicine: Effects of Strength Training on Health
Westcott, W. L. (2012) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e31825dabb8 · Cited by 778
Effects of Resistance Training on Older Adults
Hunter, G. R., McCarthy, J. P., & Bamman, M. M. (2004) · Sports Medicine · doi:10.2165/00007256-200434050-00005 · Cited by 764
Influence of Resistance Exercise on Lean Body Mass in Aging Adults: A Meta-Analysis
PETERSON, M. D., SEN, A., & GORDON, P. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181eb6265 · Cited by 558
Metadata
- Authors
- Pratley, R., Nicklas, B., Rubin, M., Miller, J., Smith, A., Smith, M., Hurley, B., & Goldberg, A.
- Affiliations
- University of Maryland, Baltimore (US)
- ORCID
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1994-01-01
- Volume
- 76
- Issue
- 1
- Pages
- 133-137
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2120739693
- Cited by
- 299
- References
- 0
- Citations by year
- 2025: 5 · 2024: 8 · 2023: 6 · 2022: 14 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 13 · 2012: 14
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08ag000494-03, 5r01ag007660-06, 5p01ag004402-10)
- National Institute on Aging (P01-AG-04402, KO8-AG-00494, R01-AG-07660)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- resistance training, resting metabolic rate, norepinephrine, fat-free mass, aging, older men, body composition, sympathetic activity, age-related metabolic decline, fat mass
- MeSH terms
- Aged, Blood Glucose, Body Composition, Body Weight, Diet, Hormones, Humans, Male, Metabolism, Middle Aged, Norepinephrine, Oxygen Consumption, Physical Education and Training
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