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Cerebral oxygenation changes in response to motor stimulation
Abstract
We studied cerebral hemodynamic response to a sequential motor task in 56 subjects to investigate the time course and distribution of blood oxygenation changes as monitored by near-infrared spectroscopy (NIRS). To address whether response is modulated by different performance velocities, a group of subjects (n = 12) was examined while performing the motor task at 1, 2, and 3 Hz. The results demonstrate that 1) the NIRS response reflects localized changes in cerebral hemodynamics, 2) the response, consisting of an increase in oxygenated hemoglobin concentration [oxy-Hb] and a decrease in deoxygenated hemoglobin concentration ([deoxy-Hb]), is lateralized and increases in amplitude with higher performance rates, and 3) changes in [oxy-Hb] and [deoxy-Hb] differ in time course. Changes in [oxy-Hb] are biphasic, with a fast initial increase and a pronounced poststimulus undershoot. The stimulus-associated decrease in [deoxy-Hb] is monophasic, and response latency is greater. We conclude that NIRS is able to detect even small changes in cerebral hemodynamic response to functional stimulation.
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Cited by
HomER: A review of time-series analysis methods for near-infrared spectroscopy of the brain
Huppert, T. J., Diamond, S. G., Franceschini, M. A., & Boas, D. A. (2009) · Applied Optics · doi:10.1364/ao.48.00d280 · Cited by 1,817
Boas, D. A., Dale, A. M., & Franceschini, M. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.011 · Cited by 721
Herold, F., Wiegel, P., Scholkmann, F., & Müller, N. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7120466 · Cited by 482
Cerebral perturbations provoked by prolonged exercise
Nybo, L., & Secher, N. H. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.005 · Cited by 398
The reticular-activating hypofrontality (RAH) model of acute exercise
Dietrich, A., & Audiffren, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.001 · Cited by 365
Metadata
- Authors
- Obrig, H., Hirth, C., Junge-Hulsing, J. G., Doge, C., Wolf, T., Dirnagl, U., & Villringer, A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1996-09-01
- Volume
- 81
- Issue
- 3
- Pages
- 1174-1183
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1921438975
- Cited by
- 227
- References
- 0
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Obrig, H., Hirth, C., Junge-Hulsing, J. G., Doge, C., Wolf, T., Dirnagl, U., & Villringer, A. (1996). Cerebral oxygenation changes in response to motor stimulation. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1996.81.3.1174
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