Influence of acute lung volume change on contractile properties of human diaphragm
Open accessAbstract
The effect of stimulus frequency on the in vivo pressure generating capacity of the human diaphragm is unknown at lung volumes other than functional residual capacity. The transdiaphragmatic pressure (Pdi) produced by a pair of phrenic nerve stimuli may be viewed as the sum of the Pdi elicited by the first (T1 Pdi) and second (T2 Pdi) stimuli. We used bilateral anterior supramaximal magnetic phrenic nerve stimulation and a digital subtraction technique to obtain the T2 Pdi at interstimulus intervals of 999, 100, 50, 33, and 10 ms in eight normal subjects at lung volumes between residual volume and total lung capacity. The reduction in T2 Pdi that we observed as lung volume increased was greatest at long interstimulus intervals, whereas the T2 Pdi obtained with short interstimulus intervals remained relatively stable over the 50% of vital capacity around functional residual capacity. For all interstimulus intervals, the total pressure produced by the pair decreased as a function of increasing lung volume. These data demonstrate that, in the human diaphragm, hyperinflation has a disproportionately severe effect on the summation of pressure responses elicited by low-frequency stimulations; this effect is distinct from and additional to the known length-tension relationship.
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The ability of the respiratory muscles to generate pressure decreases at high lung volumes in humans.
“Indeed, the ability of the respiratory muscles to generate pressure decreases at high lung volumes in humans.58,60”
From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [60]
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Physiologic Changes in the Aging Lung
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Guan, L., Xu, J., He, Z., Zha, S., Huang, Q., Niu, J., Zhou, L., & Chen, R. (2026) · Annals of Intensive Care · doi:10.1016/j.aicoj.2025.100019 · Cited by 1 · see citing works
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Antonello, M., & Delplanque, D. (2007) · Elsevier eBooks · doi:10.1016/b978-2-294-70799-5.50001-0
Physiologic Changes in the Aging Lung
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Mills, D. E. (2013) · Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)
- Authors
- Polkey, M. I., Hamnegård, C.-H., Hughes, P. D., Rafferty, G. F., Green, M., & Moxham, J.
- Affiliations
- King's College London (GB)
- Sahlgrenska University Hospital (SE)
- Royal Brompton Hospital (GB)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1998-10-01
- Volume
- 85
- Issue
- 4
- Pages
- 1322-1328
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2159313634
- Cited by
- 63
- References
- 45
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 3
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Menzies Centre for Australian Studies, King's College London, University of London
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- diaphragm, lung volume, hyperinflation, transdiaphragmatic pressure, phrenic nerve stimulation, stimulation frequency, diaphragm contractility, length-tension relationship, respiratory muscles
- MeSH terms
- Adult, Diaphragm, Female, Humans, Lung Volume Measurements, Magnetics, Male, Muscle Contraction, Phrenic Nerve, Pressure, Vital Capacity, Respiratory Mechanics
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