The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intestinal reperfusion injury is mediated by IgM and complement
Abstract
Intestinal ischemia-reperfusion injury is dependent on complement. This study examines the role of the alternative and classic pathways of complement and IgM in a murine model of intestinal ischemia-reperfusion. Wild-type animals, mice deficient in complement factor 4 (C4), C3, or Ig, or wild-type mice treated with soluble complement receptor 1 were subjected to 40 min of jejunal ischemia and 3 h of reperfusion. Compared with wild types, knockout and treated mice had significantly reduced intestinal injury, indicated by lowered permeability to radiolabeled albumin. When animals deficient in Ig were reconstituted with IgM, the degree of injury was restored to wild-type levels. Immunohistological staining of intestine for C3 and IgM showed colocalization in the mucosa of wild-type controls and minimal staining for both in the intestine of Ig-deficient and C4-deficient mice. We conclude that intestinal ischemia-reperfusion injury is dependent on the classic complement pathway and IgM.
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Wessels, M. R., Butko, P., Ma, M., Warren, H. B., Lage, A. L., & Carroll, M. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11490 · Cited by 503
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Zhou, W., Farrar, C. A., Abe, K., Pratt, J. R., Marsh, J. E., Wang, Y., Stahl, G. L., & Sacks, S. H. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8621 · Cited by 465
THE ROLE OF THE COMPLEMENT SYSTEM IN ISCHEMIA-REPERFUSION INJURY
Arumugam, T. V., Shiels, I. A., Woodruff, T. M., Granger, D. N., & Taylor, S. M. (2004) · Shock · doi:10.1097/00024382-200405000-00002 · Cited by 327
Metadata
- Authors
- Williams, J. P., Pechet, T. T. V., Weiser, M. R., Reid, R., Kobzik, L., Moore, F. D., Carroll, M. C., & Hechtman, H. B.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1999-03-01
- Volume
- 86
- Issue
- 3
- Pages
- 938-942
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2157137233
- Cited by
- 241
- References
- 1
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Williams, J. P., Pechet, T. T. V., Weiser, M. R., Reid, R., Kobzik, L., Moore, F. D., Carroll, M. C., & Hechtman, H. B. (1999). Intestinal reperfusion injury is mediated by IgM and complement. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1999.86.3.938
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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