Analysis of responses of garlic derivatives in the pulmonary vascular bed of the rat
Abstract
Allicin, an extract from garlic, has been shown to be a systemic and pulmonary arterial vasodilator that acts by an unknown mechanism. In the present experiments, pulmonary vascular responses to allicin (10–100 μg), allyl mercaptan (0.3–1 mg), and diallyl disulfide (0.3–1 mg) were studied in the isolated lung of the rat under constant-flow conditions. When baseline tone in the pulmonary vascular bed of the rat was raised to a high-steady level with the thromboxane A 2 mimic U-46619, dose-related decreases in pulmonary arterial pressure were observed. In terms of the mechanism of action of allicin vasodilator activity in the rat, responses to allicin were not significantly different after administration of the nitric oxide synthase inhibitor N ω-nitro-l-arginine methyl ester, the K ATP+channel antagonist U-37883A, or the cyclooxygenase inhibitor sodium meclofenamate, or when lung ventilation was interrupted. These data show that allicin has significant vasodilator activity in the pulmonary vascular bed of the rat, whereas allyl mercaptan and diallyl disulfide produced no significant changes in pulmonary arterial perfusion pressure. The present data suggest that pulmonary vasodilator responses to allicin are independent of the synthesis of nitric oxide, ATP-sensitive K+channels, activation of cyclooxygenase enzyme, or changes in bronchomotor tone in the pulmonary vascular bed of the rat.
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Allyl mercaptan is the odorant molecule responsible for garlic breath and results from the interaction of allicin or diallyl disulfide with cysteine in the presence of S-ally-mercapto cysteine.
“Allyl mercaptan is the odorant molecule responsible for the garlic breath and results from the interaction of allicin or diallyl disulfide with cysteine in the presence of S-ally-mercapto cysteine [25,26].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [25]
Alliin is the main precursor of allicin, representing about 70% of total thiosulfinates in crushed garlic cloves.
“Alliin (S-allyl-L-cysteine sulfoxide) is the main precursor of allicin, which represents about 70% of total thiosulfinates existing in the crushed cloves [25].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [25]
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ALOPESİ AREATA TEDAVİSİNDE POTANSİYEL BAZI TIBBİ BİTKİ TÜRLERİNİN İNCELENMESİ
Şerbetçi, T., & İbrahim, H. B. (2025) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.1537612
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- Authors
- Kaye, A. D., De Witt, B. J., Anwar, M., Smith, D. E., Feng, C. J., Kadowitz, P. J., & Nossaman, B. D.
- Affiliations
- Texas Tech University (US)
- Departments of Anesthesiology and Pharmacology, Tulane University Medical Center, New Orleans, Louisiana 70112
- Tulane University (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2000-07-01
- Volume
- 89
- Issue
- 1
- Pages
- 353-358
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1951788454
- Cited by
- 49
- References
- 22
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2016: 4 · 2015: 3 · 2014: 1 · 2012: 1
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- allicin, pulmonary vasodilation, pulmonary vasculature, allyl mercaptan, diallyl disulfide, nitric oxide, ATP-sensitive potassium channels, cyclooxygenase, U46619, pulmonary artery pressure, isolated lung perfusion
- MeSH terms
- Adamantane, Allyl Compounds, Animals, Antihypertensive Agents, Antioxidants, Bronchodilator Agents, Disulfides, Diuretics, Enzyme Inhibitors, Garlic, Hypertension, Pulmonary, Lung Diseases, Obstructive, Male, Meclofenamic Acid, Morpholines, Plants, Medicinal, Pulmonary Circulation, Respiration, Sulfhydryl Compounds, Sulfinic Acids, Vasoconstrictor Agents, Cyclooxygenase Inhibitors, Rats, Sprague-Dawley, NG-Nitroarginine Methyl Ester, 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid, Cromakalim, Rats
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