The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model
Abstract
Using a newly developed perfused rat brain model, we examined direct effects of each change in cerebral blood flow (CBF) and oxygen metabolic rate on cerebral hemoglobin oxygenation to interpret near-infrared spectroscopy signals. Changes in CBF and total hemoglobin (tHb) were in parallel, although tHb showed no change when changes in CBF were small (≤10%). Increasing CBF caused an increase in oxygenated hemoglobin (HbO 2) and a decrease in deoxygenated hemoglobin (deoxy-Hb). Decreasing CBF was accompanied by a decrease in HbO 2, whereas changes in direction of deoxy-Hb were various. Cerebral blood congestion caused increases in HbO 2, deoxy-Hb, and tHb. Administration of pentylenetetrazole without increasing the flow rate caused increases in HbO 2 and tHb with a decrease in deoxy-Hb. There were no significant differences in venous oxygen saturation before vs. during seizure. These results suggest that, in activation studies with near-infrared spectroscopy, HbO 2 is the most sensitive indicator of changes in CBF, and the direction of changes in deoxy-Hb is determined by the degree of changes in venous blood oxygenation and volume.
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Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056
Cited by
Cortical Mapping of Gait in Humans: A Near-Infrared Spectroscopic Topography Study
Miyai, I., Tanabe, H. C., Sase, I., Eda, H., Oda, I., Konishi, I., Tsunazawa, Y., Suzuki, T., Yanagida, T., & Kubota, K. (2001) · NeuroImage · doi:10.1006/nimg.2001.0905 · Cited by 788
Boas, D. A., Dale, A. M., & Franceschini, M. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.011 · Cited by 721
Takahashi, T., Takikawa, Y., Kawagoe, R., Shibuya, S., Iwano, T., & Kitazawa, S. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.012 · Cited by 396
The reticular-activating hypofrontality (RAH) model of acute exercise
Dietrich, A., & Audiffren, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.001 · Cited by 365
Syncope, cerebral perfusion, and oxygenation
Van Lieshout, J. J., Wieling, W., Karemaker, J. M., & Secher, N. H. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00260.2002 · Cited by 365
Metadata
- Authors
- Hoshi, Y., Kobayashi, N., & Tamura, M.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2001-05-01
- Volume
- 90
- Issue
- 5
- Pages
- 1657-1662
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2151756070
- Cited by
- 850
- References
- 1
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- closed
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