The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions
Abstract
This study was performed to explore changes in gene expression as a consequence of exercise training at two levels of intensity under normoxic and normobaric hypoxic conditions (corresponding to an altitude of 3,850 m). Four groups of human subjects trained five times a week for a total of 6 wk on a bicycle ergometer. Muscle biopsies were taken, and performance tests were carried out before and after the training period. Similar increases in maximal O 2 uptake (8.3–13.1%) and maximal power output (11.4–20.8%) were found in all groups. RT-PCR revealed elevated mRNA concentrations of the α-subunit of hypoxia-inducible factor 1 (HIF-1) after both high- (+82.4%) and low (+78.4%)-intensity training under hypoxic conditions. The mRNA of HIF-1α 736, a splice variant of HIF-1α newly detected in human skeletal muscle, was shown to be changed in a similar pattern as HIF-1α. Increased mRNA contents of myoglobin (+72.2%) and vascular endothelial growth factor (+52.4%) were evoked only after high-intensity training in hypoxia. Augmented mRNA levels of oxidative enzymes, phosphofructokinase, and heat shock protein 70 were found after high-intensity training under both hypoxic and normoxic conditions. Our findings suggest that HIF-1 is specifically involved in the regulation of muscle adaptations after hypoxia training. Fine-tuning of the training response is recognized at the molecular level, and with less sensitivity also at the structural level, but not at global functional responses like maximal O 2 uptake or maximal power output.
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Metadata
- Authors
- Vogt, M., Puntschart, A., Geiser, J., Zuleger, C., Billeter, R., & Hoppeler, H.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2001-07-01
- Volume
- 91
- Issue
- 1
- Pages
- 173-182
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2175185932
- Cited by
- 422
- References
- 51
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vogt, M., Puntschart, A., Geiser, J., Zuleger, C., Billeter, R., & Hoppeler, H. (2001). Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions. Journal of Applied Physiology. https://doi.org/10.1152/jappl.2001.91.1.173
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