The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hyperthermia and central fatigue during prolonged exercise in humans
Abstract
The present study investigated the effects of hyperthermia on the contributions of central and peripheral factors to the development of neuromuscular fatigue. Fourteen men exercised at 60% maximal oxygen consumption on a cycle ergometer in hot (40°C; hyperthermia) and thermoneutral (18°C; control) environments. In hyperthermia, the core temperature increased throughout the exercise period and reached a peak value of 40.0 ± 0.1°C (mean ± SE) at exhaustion after 50 ± 3 min of exercise. In control, core temperature stabilized at ∼38.0 ± 0.1°C, and exercise was maintained for 1 h without exhausting the subjects. Immediately after the cycle trials, subjects performed 2 min of sustained maximal voluntary contraction (MVC) either with the exercised legs (knee extension) or with a “nonexercised” muscle group (handgrip). The degree of voluntary activation during sustained maximal knee extensions was assessed by superimposing electrical stimulation (EL) to nervus femoralis. Voluntary knee extensor force was similar during the first 5 s of contraction in hyperthermia and control. Thereafter, force declined in both trials, but the reduction in maximal voluntary force was more pronounced in the hyperthermic trial, and, from 30 to 120 s, the force was significantly lower in hyperthermia compared with control. Calculation of the voluntary activation percentage (MVC/MVC + EL) revealed that the degree of central activation was significantly lower in hyperthermia (54 ± 7%) compared with control (82 ± 6%). In contrast, total force of the knee extensors (MVC + force from EL) was not different in the two trials. Force development during handgrip contraction followed the same pattern of response as was observed for the knee extensors. In conclusion, these data demonstrate that the ability to generate force during a prolonged MVC is attenuated with hyperthermia, and the impaired performance is associated with a reduction in the voluntary activation percentage.
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“Central fatigue, as indicated by an impaired ability to sustain maximal muscle activation during sustained contractions, has been implicated in exercise performance decrements associated with hyperthermia [165–167].”
From Fluid Balance in Team Sport Athletes and the Effect of Hypohydration on Cognitive, Technical, and Physical Performance (2017) · cites this paper as [166]
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Cites
Temperature, skeletal muscle mitochondrial functions, and oxygen debt
Brooks, G., Hittelman, K., Faulkner, J., & Beyer, R. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.220.4.1053 · Cited by 261
Effect of heat stress on muscle energy metabolism during exercise
Febbraio, M. A., Snow, R. J., Stathis, C. G., Hargreaves, M., & Carey, M. F. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.6.2827 · Cited by 219 · cited 2×
“The detrimental effects of whole body hyperthermia and high Tmu on muscle metabolism are well documented (12, 23), but these factors seem to play only a minimal role in the development of fatigue during prolonged exercise in hot environments (16, 18, 22).”
Background
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Cited by
Exercise and Fluid Replacement
(2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802ca597 · Cited by 1,497
Fatigue in soccer: A brief review
Mohr, M., Krustrup, P., & Bangsbo, J. (2005) · Journal of Sports Sciences · doi:10.1080/02640410400021286 · Cited by 689
Sawka, M. N., Leon, L. R., Montain, S. J., & Sonna, L. A. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100082 · Cited by 470
Cerebral perturbations provoked by prolonged exercise
Nybo, L., & Secher, N. H. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.005 · Cited by 398
Self-citationCerebral blood flow and metabolism during exercise: implications for fatigue
Secher, N. H., Seifert, T., & Van Lieshout, J. J. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00853.2007 · Cited by 344
Metadata
- Authors
- Nybo, L., & Nielsen, B.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2001-09-01
- Volume
- 91
- Issue
- 3
- Pages
- 1055-1060
- ISSN
- 8750-7587
- 1522-1601
- Cited by
- 492
- References
- 2
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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