Cited by 2Thermoregulation and physiological responsesCardiovascular and exercise physiologyPhysical Activity and Health

Impact of age, cardiorespiratory fitness, and regular physical activity on physiological strain and cognitive performance during a 6-h extreme heat exposure

Open access
Brown, Harry A., John, Kevin, Elliott, Josh D., Deshayes, Thomas A., Gagnon, Daniel, Jay, Ollie, Clark, Brad, Périard, Julien D.·2026·Journal of Applied Physiology

Abstract

Advancing age is associated with progressive increases in the rise in core temperature during extreme heat exposure, and this trajectory is evident across the entire adult lifespan rather than emerging only in older adults. Thermoregulatory capacity declines steadily with each decade, leading to greater thermal strain even in mid-adulthood. Although higher cardiorespiratory fitness enhances sweating, it does not eliminate the age-related increase in core temperature, underscoring that heat vulnerability may develop gradually throughout adulthood.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.00105.2026

Cites

65 of 65 references verified0 citation errors · 0 not checkable

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Cites

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Research works printed but not linked: 5

  1. Armstrong LE, 1988, Human Performance Physiology Environmental Medicine at Terrestrial Extremes, 199
  2. Pescatello LS, 2014, ACSM’s Guidelines for Exercise Testing and Prescription
  3. Toolbox Assessments I, 2023, NIH Toolbox V3
  4. Inoue Y, 1999, Descente Sports Science, 20, 254
  5. Pandolf KB, 1988, Human Performance Physiology and Environmental Medicine at Terrestrial Extremes

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Authors
Brown, H. A., John, K., Elliott, J. D., Deshayes, T. A., Gagnon, D., Jay, O., Clark, B., & Périard, J. D.
Affiliations
  • The University of Sydney (AU)
  • University of Canberra (AU)
  • University of Canberra
  • Université de Sherbrooke (CA)
  • Montreal Heart Institute (CA)
Corresponding author
  • Brown, Harry A.
  • Périard, Julien D.
Venue
Journal of Applied Physiology
Published
2026-06-01
Volume
140
Issue
6
Pages
1721-1731
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
OpenAlex
W7161411470
Cited by
2
References
65
Citations by year
2026: 2
FWCI
7.50
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Applied Physiology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • OSF Preprints (OSF Preprints) (submittedVersion)
  • Open Science Framework
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
extreme heat exposure, aging, cardiorespiratory fitness, physical activity, core body temperature, thermoregulation, heat strain, cognitive performance, sweating, heat vulnerability, midlife
MeSH terms
Cardiorespiratory Fitness, Adult, Aged, Aging, Body Temperature Regulation, Cognition, Female, Heart Rate, Hot Temperature, Humans, Male, Middle Aged, Oxygen Consumption, Sweating, Exercise, Young Adult

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