The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Oxidative protein damage is associated with poor grip strength among older women living in the community
Open accessAbstract
Grip strength, an indicator of muscle strength, has been shown to be a predictor of poor outcomes among older adults. Protein carbonylation, an indicator of oxidative damage to proteins, leads to cellular dysfunction and a decline in tissue function. Oxidative stress has been implicated in the pathogenesis of sarcopenia. The objective was to determine whether serum protein carbonyl concentrations are associated with grip strength in older women living in the community. A cross-sectional study was conducted in 672 women, aged 65 and older, from the Women's Health and Aging Study (WHAS) I, the one-third most disabled women residing in the community in Baltimore, MD. Protein carbonyl and grip strength were measured in each patient. In a multivariate analysis adjusting for age, race, body mass index, and Mini-Mental Status Examination score, protein carbonyls (nmol/mg) were associated with grip strength (β = −6.77, P < 0.01). The statistical association was unchanged after the analysis adjusted for hypertension, congestive heart failure, and depression. Ordered logistic regression models adjusted for the above factors showed that protein carbonyls are associated with increased odds of being in the lower quartiles of grip strength (odds ratio 8.74, 95% confidence interval 1.06–71.89, P = 0.043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults.
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“Sarcopenia has been defined as progressive loss of skeletal muscle mass, strength and power and is considered a key component of frailty (66, 67).”
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Protein carbonyl groups as biomarkers of oxidative stress
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Self-citationOxidative capacity and ageing in human muscle
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Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503
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Frailty Syndrome: A Transitional State in a Dynamic Process
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Oxidative Stress, Molecular Inflammation and Sarcopenia
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Metadata
- Authors
- Howard, C., Ferrucci, L., Sun, K., Fried, L. P., Walston, J., Varadhan, R., Guralnik, J. M., & Semba, R. D.
- Affiliations
- Johns Hopkins University (US)
- National Institute on Aging (US)
- National Institutes of Health (US)
- Corresponding author
- Howard, Caitlin
- ORCID
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2007-07
- Volume
- 103
- Issue
- 1
- Pages
- 17-20
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC2646087
- OpenAlex
- W2167239370
- Cited by
- 214
- References
- 22
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 9 · 2021: 10 · 2020: 15 · 2019: 9 · 2018: 14 · 2017: 12 · 2016: 9 · 2015: 15 · 2014: 14 · 2013: 17 · 2012: 11
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health (Z99 AG999999)
- National Institute on Aging (R01AG027012, P30AG021334)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- grip strength, protein carbonylation, oxidative protein damage, oxidative stress, sarcopenia, muscle strength, older women, community-dwelling older adults, Women's Health and Aging Study
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Female, Health Status Indicators, Humans, Muscular Diseases, Proteins, Baltimore, Biomarkers, Linear Models, Logistic Models, Odds Ratio, Frail Elderly, Oxidative Stress, Muscle, Skeletal, Risk Assessment, Hand Strength, Protein Carbonylation
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