Oxidatively modified proteins in aging and disease1, 2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease” The full list of papers may be found on the homepage of the journal

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,551 · see citing works

Age-related changes in oxidized proteins.

Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306 · see citing works

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296 · see citing works

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046 · see citing works

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897 · see citing works

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410514 · Cited by 885 · see citing works

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

Ferrante, R. J., Browne, S. E., Shinobu, L. A., Bowling, A. C., Baik, M. J., MacGarvey, U. M., Kowall, N. W., Brown, R. H., & Beal, M. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052064.x · Cited by 808 · see citing works

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788 · see citing works

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

Hensley, K., Hall, N., Subramaniam, R., Cole, P., Harris, M., Aksenov, M., Aksenova, M., Gabbita, S. P., Wu, J. F., Carney, J. M., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052146.x · Cited by 779 · see citing works

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

Oliver, C., Starke-Reed, P. E., Stadtman, E. R., Liu, G. J., Carney, J. M., & Floyd, R. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5144 · Cited by 771 · see citing works

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

Hsu, L. J., Sagara, Y., Arroyo, A., Rockenstein, E. M., Sisk, A., Mallory, M. E., Wong, J., Takenouchi, T., Hashimoto, M., & Masliah, E. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64553-1 · Cited by 716 · see citing works

Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

Moskovitz, J., Barnoy, S., Williams, W. M., Requena, J. R., Berlett, B. S., & Stadtman, E. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231472998 · Cited by 677 · see citing works

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

Przedborski, S., Jackson-Lewis, V. R., Yokoyama, R., Shibata, T., Dawson, V. L., & Dawson, T. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4565 · Cited by 624 · see citing works

Oxidative damage during aging targets mitochondrial aconitase

Yan, L., Levine, R. L., & Sohal, R. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11168 · Cited by 620 · see citing works

Evidence of neuronal oxidative damage in Alzheimer's disease.

Good, P. F., Werner, P., Hsu, A., Olanow, C. W., & Perl, D. P. (1996) · Europe PMC (PubMed Central) · Cited by 600 · see citing works

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

Beal, M. F., Ferrante, R. J., Browne, S. E., Matthews, R. T., Kowall, N. W., & Brown, R. H. (1997) · Annals of Neurology · doi:10.1002/ana.410420416 · Cited by 599 · see citing works

Dityrosine Cross-linking Promotes Formation of Stable α-Synuclein Polymers

Souza, J. M., Giasson, B. I., Chen, Q., Lee, V. M. ‐., & Ischiropoulos, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000206200 · Cited by 561 · see citing works

A Generalised Increase in Protein Carbonyls in the Brain in Parkinson's but Not Incidental Lewy Body Disease

Alam, Z. I., Daniel, S. E., Lees, A. J., Marsden, D. C., Jenner, P. G., & Halliwell, B. B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031326.x · Cited by 547 · see citing works

Protein Nitration in Parkinsonʼs Disease

Good, P. F., Hsu, A., Werner, P., Perl, D. P., & Olanow, C. W. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199804000-00006 · Cited by 540 · see citing works

Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

Hensley, K., Maidt, M. L., Yu, Z., Sang, H., Markesbery, W. R., & Floyd, R. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08126.1998 · Cited by 508 · see citing works

The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

Lauderback, C. M., Hackett, J. M., Huang, F. F., Keller, J. N., Szweda, L. I., Markesbery, W. R., & Butterfield, D. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00451.x · Cited by 464 · see citing works

Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle

Mecocci, P., Fanò, G., Fulle, S., MacGarvey, U. M., Shinobu, L. A., Polidori, M. C., Cherubini, A., Vecchiet, J., Senin, U., & Beal, M. F. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00208-1 · Cited by 461 · see citing works

Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult

Paxinou, E., Chen, Q., Weisse, M., Giasson, B. I., Norris, E. H., Rueter, S. M., Trojanowski, J. Q., Lee, V. M. ‐., & Ischiropoulos, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08053.2001 · Cited by 440 · see citing works

Inhibition of neuronal nitric oxide synthase prevents MPTP–induced parkinsonism in baboons

Hantraye, P., Brouillet, E., Ferrante, R. J., Palfi, S., Dolan, R., Matthews, R. T., & Beal, M. F. (1996) · Nature Medicine · doi:10.1038/nm0996-1017 · Cited by 422 · see citing works

Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice

Schulz, J. B., Matthews, R. T., Muqit, M. M. K., Browne, S. E., & Beal, M. F. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020936.x · Cited by 417 · see citing works

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

Yan, L.-J., & Sohal, R. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12896 · Cited by 414 · see citing works

Protein‐Bound Acrolein

Calingasan, N. Y., Uchida, K., & Gibson, G. E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720751.x · Cited by 400 · see citing works

Protein oxidation and proteolysis during aging and oxidative stress

Starke-Reed, P. E., & Oliver, C. N. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90402-5 · Cited by 398 · see citing works

Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

Pedersen, W. A., Fu, W., Keller, J. N., Markesbery, W. R., Appel, S. H., Smith, R. G., Kasarskis, E. J., & Mattson, M. P. (1998) · Annals of Neurology · doi:10.1002/ana.410440518 · Cited by 391 · see citing works

Protein oxidative damage is associated with life expectancy of houseflies.

Sohal, R. S., Agarwal, S., Dubey, A., & Orr, W. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7255 · Cited by 354 · see citing works

Proteomic method identifies proteins nitrated <i>in vivo</i> during inflammatory challenge

Aulak, K. S., Miyagi, M., Yan, L., West, K. A., Massillon, D., Crabb, J. W., & Stuehr, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221269198 · Cited by 350 · see citing works

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.

Kong, S. K., Yim, M. B., Stadtman, E. R., & Chock, P. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3377 · Cited by 335 · see citing works

Oxidative damage to protein in sporadic motor neuron disease spinal cord

Shaw, P. J., Ince, P. G., Falkous, G., & Mantle, D. (1995) · Annals of Neurology · doi:10.1002/ana.410380424 · Cited by 331 · see citing works

Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease

Castellani, R. J., Smith, M. A., Richey, G. L., & Perry, G. L. (1996) · Brain Research · doi:10.1016/0006-8993(96)00729-9 · Cited by 315 · see citing works

Neural Heme Oxygenase-1 Expression in Idiopathic Parkinson's Disease

Schipper, H. M., Liberman, A., & Stopa, E. G. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6752 · Cited by 300 · see citing works

Neural roles for heme oxygenase: Contrasts to nitric oxide synthase

Barañano, D. E., & Snyder, S. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191351298 · Cited by 293 · see citing works

Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease.

Yoram Vodovotz, B., Lucia, M. S., Flanders, K. C., Chesler, L., Xie, Q. W., Smith, T. W., Weidner, J. R., Mumford, R. A., Webber, R., Nathan, C., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1425 · Cited by 289 · see citing works

Acceleration of Peroxynitrite Oxidations by Carbon Dioxide

Uppu, R. M., Squadrito, G. L., & Pryor, W. A. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0131 · Cited by 279 · see citing works

Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

Abe, K., Pan, L.-H., Watanabe, M., Kato, T., & Itoyama, Y. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12039-7 · Cited by 263 · see citing works

Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

Bogdanov, M., Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., & Beal, M. F. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00689.x · Cited by 248 · see citing works

Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease

Smith, M. A., Rudnicka-Nawrot, M., Richey, P., Praprotnik, D., Mulvihill, P., Miller, C., Sayre, L., & Perry, G. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64062660.x · Cited by 240 · see citing works

Tyrosine Modifications and Inactivation of Active Site Manganese Superoxide Dismutase Mutant (Y34F) by Peroxynitrite

MacMillan-Crow, L. A., & Thompson, J. A. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1202 · Cited by 227 · see citing works

Cytochemical Demonstration of Oxidative Damage in Alzheimer Disease by Immunochemical Enhancement of the Carbonyl Reaction with 2,4-Dinitrophenylhydrazine

Smith, M. A., Sayre, L. M., Anderson, V. E., Harris, P. L. R., Beal, M. F., Kowall, N. W., & Perry, G. L. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804600605 · Cited by 222 · see citing works

Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle

Pansarasa, O., Bertorelli, L., Vecchiet, J., Felzani, G., & Marzatico, F. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00108-2 · Cited by 212 · see citing works

Verbal fluency activates the left medial temporal lobe: A functional magnetic resonance imaging study

Pihlajam�ki, M., Tanila, H., H�nninen, T., Könönen, M., Laakso, M. P., Partanen, K. P. L., Soininen, H. S., & Aronen, H. J. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4 · Cited by 210 · see citing works

Mitochondrial Creatine Kinase Is a Prime Target of Peroxynitrite-induced Modification and Inactivation

Stachowiak, O., Dolder, M., Wallimann, T., & Richter, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16694 · Cited by 189 · see citing works

Nitric Oxide Synthase in Reactive Astrocytes Adjacent to β-Amyloid Plaques

Wallace, M. N., Geddes, J. G., Farquhar, D. A., & Masson, M. R. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6373 · Cited by 181 · see citing works

Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain

Su, J. H., Deng, G., & Cotman, C. W. (1997) · Brain Research · doi:10.1016/s0006-8993(97)81703-9 · Cited by 175 · see citing works

Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease

Tohgi, H., Abe, T., Yamazaki, K., Murata, T., Ishizaki, E., & Isobe, C. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00406-1 · Cited by 173 · see citing works

Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

Sohal, R. S., Agarwal, S., & Sohal, B. H. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)01578-a · Cited by 171 · see citing works

Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis

Abe, K., Pan, L.-H., Watanabe, M., Konno, H., Kato, T., & Itoyama, Y. (1997) · Neurological Research · doi:10.1080/01616412.1997.11740784 · Cited by 167 · see citing works

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

Chou, S. M., Wang, H. S., & Komai, K. (1996) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(96)00137-8 · Cited by 153 · see citing works

Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid

Ando, Y., Brännström, T., Uchida, K., Nyhlin, N., Näsman, B., Suhr, O. B., Yamashita, T., Olsson, T., Salhy, M. E., Uchino, M., et al. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00042-2 · Cited by 152 · see citing works

Carbon dioxide stimulates peroxynitrite-mediated nitration of tyrosine residues and inhibits oxidation of methionine residues of glutamine synthetase: Both modifications mimic effects of adenylylation

Berlett, B. S., Levine, R. L., & Stadtman, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2784 · Cited by 152 · see citing works

Superoxide Dismutase Concentration and Activity in Familial Amyotrophic Lateral Sclerosis

Bowling, A. C., Barkowski, E. E., McKenna‐Yasek, D., Sapp, P. C., Horvitz, H. R., Beal, M. F., & Brown, R. H. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052366.x · Cited by 129 · see citing works

Oxidative Damage to Proteins, Lipids, and DNA in Cortical Brain Regions from Patients with Dementia with Lewy Bodies

Lyras, L., Perry, R. H., Perry, E. K., Ince, P. G., Jenner, A. M., Jenner, P. G., & Halliwell, B. B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71010302.x · Cited by 121 · see citing works

Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins

Yan, L., & Sohal, R. S. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00423-8 · Cited by 115 · see citing works

Modification of hepatic proteins in rats exposed to high oxygen concentration

Starke-Reed, P. E., Oliver, C. N., & Stadtman, E. R. (1987) · The FASEB Journal · doi:10.1096/fasebj.1.1.2886388 · Cited by 109 · see citing works

Increased Expression of Neuronal Nitric Oxide Synthase Spliced Variants in Reactive Astrocytes of Amyotrophic Lateral Sclerosis Human Spinal Cord

Catania, M. V., Aronica, E., Yankaya, B., & Troost, D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-j0002.2001 · Cited by 91 · see citing works

Oxidative Damage and Motor Neurone Disease Difficulties in the Measurement of Protein Carbonyls in Human Brain Tissue

Lyras, L., Evans, P., Shaw, P. J., Ince, P. G., & Halliwell, B. B. (1996) · Free Radical Research · doi:10.3109/10715769609088038 · Cited by 76 · see citing works

Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice

Wendt, S., Dedeoglu, A., Speer, O., Wallimann, T., Beal, M. F., & Andreassen, O. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00784-0 · Cited by 65 · see citing works

Rapid Reactions of Peroxynitrite with Heme–Thiolate Proteins as the Basis for Protection of Prostacyclin Synthase from Inactivation by Nitration

Zou, M., Daiber, A., Peterson, J. A., Shoun, H., & Ullrich, V. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1699 · Cited by 60 · see citing works

Detection of Nitrosyl Complexes in Human Substantia Nigra, in Relation to Parkinson's Disease

Shergill, J. K., Cammack, R., Cooper, C. E., Cooper, J. A. D., Mann, V. M., & Schapira, A. H. V. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1656 · Cited by 59 · see citing works

Altered Glycosylation Pattern of Proteins in Alzheimer Disease

Guevara, J., Espinosa, B., Zenteno, E., Vázquez, L., Luna, J., Perry, G. L., & Mena, R. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199810000-00003 · Cited by 53 · see citing works

Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease

Smith, M. A., Vašák, M., Knipp, M., Castellani, R. J., & Perry, G. L. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00119-1 · Cited by 52 · see citing works

No Evidence for Increased Oxidative Damage to Lipids, Proteins, or DNA in Huntington's Disease

Alam, Z. I., Halliwell, B. B., & Jenner, P. G. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750840.x · Cited by 50 · see citing works

Meningeal cells can communicate with astrocytes by calcium signaling

Grafstein, B., Liu, S., Cotrina, M. L., Goldman, S. A., & Nedergaard, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200001)47:1 · Cited by 50 · see citing works

Glial Cells of the Spinal Cord and Subcortical White Matter Up-regulate Neuronal Nitric Oxide Synthase in Sporadic Amyotrophic Lateral Sclerosis

Anneser, J. M. H., Cookson, M., Ince, P. G., Shaw, P. J., & Borasio, G. D. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7756 · Cited by 47 · see citing works

Exploitation of the HIV‐1 coat glycoprotein, gp120, in neurodegenerative studies in vivo

Corasaniti, M. T., Maccarrone, M., Nisticò, R., Malorni, W., Rotiroti, D., & Bagetta, G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00537.x · Cited by 39 · see citing works

Neuronal nitric oxide synthase immunoreactivity in the spinal cord in amyotrophic lateral sclerosis

Sasaki, S., Shibata, N., & Iwata, M. (2001) · Acta Neuropathologica · doi:10.1007/s004010000282 · Cited by 37 · see citing works

Aging effects of vitamin C on a human lens protein produced in vitro

Russell, P., Garland, D. L., Zigler, J. S., Meakin, S. O., Tsui, L., & Breitman, M. L. (1987) · The FASEB Journal · doi:10.1096/fasebj.1.1.3301496 · Cited by 29 · see citing works

Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease.

van Geel (2001) · Open Repository and Bibliography (University of Luxembourg) · doi:10.1002/1531-8249(20010201)49:2 · Cited by 7 · see citing works

Untitled work

Waldvogel (1999) · doi:10.1002/1531-8249(199907)46:1

The role of antioxidants in the chemistry of oxidative stress: A review

Pisoschi, A. M., & Pop, A. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.04.040 · Cited by 2,844 · see citing works

Protein carbonyl groups as biomarkers of oxidative stress

Dalle‐Donne, I., Rossi, R., Giustarini, D., Milzani, A., & Colombo, R. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00003-2 · Cited by 2,352 · see citing works

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

Wang, R. (2012) · Physiological Reviews · doi:10.1152/physrev.00017.2011 · Cited by 1,939 · see citing works

Oxidative DNA damage and disease: induction, repair and significance

Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372 · see citing works

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

Glutathione dysregulation and the etiology and progression of human diseases

Ballatori, N., Krance, S. M., Notenboom, S., Shi, S., Tieu, K., & Hammond, C. L. (2009) · Biological Chemistry · doi:10.1515/bc.2009.033 · Cited by 1,118 · see citing works

Mechanism of Oxidative Stress in Neurodegeneration

Gandhi, S., & Abramov, A. Y. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/428010 · Cited by 964 · see citing works

Protein carbonylation in human diseases

Dalle-Donne, I., Giustarini, D., Colombo, R., Rossi, R., & Milzani, A. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00031-5 · Cited by 961 · see citing works

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855 · see citing works

Protein carbonylation, cellular dysfunction, and disease progression

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Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

Soon, C. P. W., Donnelly, P. S., Turner, B. J., Hung, L. W., Crouch, P. J., Sherratt, N. A., Tan, J., Lim, N. K.-H., Lam, L. Q., Bica, L., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274407 · Cited by 155 · see citing works

Free radical processes in aging, neurodegenerative diseases and other pathological states

Dubinina, E. E., & Васильевна, П. А. (2007) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750807040026 · Cited by 15 · see citing works

Protein oxidative modifications in the ageing brain: Consequence for the onset of neurodegenerative disease

Grimm, S., Höhn, A., Davies, K. J. A., & Grune, T. (2010) · Free Radical Research · doi:10.3109/10715762.2010.512040 · Cited by 108 · see citing works

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

Butterfield, D. A., Marzia Perluigi, A., Reed, T. T., Muharib, T., Hughes, C. P., Robinson, R. A. S., & Rukhsana Sultana, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4109 · Cited by 167 · see citing works

Human studies related to protein oxidation: protein carbonyl content as a marker of damage.

Chevion, M., Berenshtein, E., & Stadtman, E. R. (2000) · PubMed · Cited by 400 · see citing works

Protein Oxidation in Aging and Age‐Related Diseases

Stadtman, E. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05632.x · Cited by 660 · see citing works