The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: a pilot study
Abstract
Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Exercise training is an established adjuvant therapy in heart failure; however, the effects of high-intensity interval training (HIIT) in HFpEF are unknown. We compared the effects of HIIT vs. moderate-intensity aerobic continuous training (MI-ACT) on peak oxygen uptake (V̇o 2peak), left ventricular diastolic dysfunction, and endothelial function in patients with HFpEF. Nineteen patients with HFpEF (age 70 ± 8.3 yr) were randomized to either HIIT (4 × 4 min at 85-90% peak heart rate, with 3 min active recovery) or MI-ACT (30 min at 70% peak heart rate). Fifteen patients completed exercise training (HIIT: n = 9; MI-ACT: n = 6). Patients trained 3 days/wk for 4 wk. Before and after training patients underwent a treadmill test for V̇o 2peak determination, 2D-echocardiography for assessment of left ventricular diastolic dysfunction, and brachial artery flow-mediated dilation (FMD) for assessment of endothelial function. HIIT improved V̇o 2peak (pre = 19.2 ± 5.2 ml·kg−1·min−1; post = 21.0 ± 5.2 ml·kg−1·min−1; P = 0.04) and left ventricular diastolic dysfunction grade (pre = 2.1 ± 0.3; post = 1.3 ± 0.7; P = 0.02), but FMD was unchanged (pre = 6.9 ± 3.7%; post = 7.0 ± 4.2%). No changes were observed following MI-ACT. A trend for reduced left atrial volume index was observed following HIIT compared with MI-ACT (−3.3 ± 6.6 vs. +5.8 ± 10.7 ml/m 2; P = 0.06). In HFpEF patients 4 wk of HIIT significantly improved V̇o 2peak and left ventricular diastolic dysfunction. HIIT may provide a more robust stimulus than MI-ACT for early exercise training adaptations in HFpEF.
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Statistical Power Analysis for the Behavioral Sciences
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Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
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Recommendations for the evaluation of left ventricular diastolic function by echocardiography
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Ross, R., Blair, S. N., Arena, R., Church, T. S., Després, J.-P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000461 · Cited by 2,486
2020 ESC guidelines on sports cardiology and exercise in patients with cardiovascular disease
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Self-citationCosta, E. C., Hay, J. L., Kehler, D. S., Boreskie, K. F., Arora, R. C., Umpierre, D., Szwajcer, A., & Duhamel, T. A. (2018) · Sports Medicine · doi:10.1007/s40279-018-0944-y · Cited by 281
Wewege, M. A., Ahn, D., Yu, J., Liou, K., & Keech, A. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009305 · Cited by 214
Metadata
- Authors
- Angadi, S. S., Mookadam, F., Lee, C. D., Tucker, W. J., Haykowsky, M. J., & Gaesser, G. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2015-09-15
- Volume
- 119
- Issue
- 6
- Pages
- 753-758
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2045019896
- Cited by
- 260
- References
- 9
- FWCI
- 27.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Angadi, S. S., Mookadam, F., Lee, C. D., Tucker, W. J., Haykowsky, M. J., & Gaesser, G. A. (2015). High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: a pilot study. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00518.2014
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