Effect of Endurance Exercise Training on Endothelial Function and Arterial Stiffness in Older Patients With Heart Failure and Preserved Ejection Fraction
Open accessAbstract
Objectives The study sought to evaluate the effects of endurance exercise training (ET) on endothelial-dependent flow-mediated arterial dilation (FMD) and carotid artery stiffness, and their potential contributions to the training-related increase in peak exercise oxygen consumption (Vo2) in older patients with heart failure with preserved ejection fraction (HFPEF).Background Elderly HFPEF patients have severely reduced peak Vo2, which improves with ET, however, the mechanisms of this improvement are unclear. FMD and arterial distensibility are critical components of the exercise response and are reduced with aging. However, it is unknown whether these improve with ET in elderly HFPEF or contribute to the training-related improvement in peak Vo2.Methods A total of 63 HFPEF patients (age 70 ± 7 years) were randomized to 16 weeks of ET (walking, arm and leg ergometry, n = 32) or attention control (CT) (n = 31). Peak Vo2, brachial artery FMD in response to cuff ischemia, carotid artery distensibility by high-resolution ultrasound, left ventricular function, and quality of life were measured at baseline and follow-up.Results ET increased peak Vo2 (ET: 15.8 ± 3.3 ml/kg/min vs. CT: 13.8 ± 3.1 ml/kg/min, p = 0.0001) and quality of life. However, brachial artery FMD (ET: 3.8 ± 3.0% vs. CT: 4.3 ± 3.5%, p = 0.88), and carotid arterial distensibility (ET: 0.97 ± 0.56 vs. CT: 1.07 ± 0.34 × 10(-3) mm·mm Hg(-2); p = 0.65) were unchanged. Resting left ventricular systolic and diastolic function were unchanged by ET.Conclusions In elderly HFPEF patients, 16 weeks of ET improved peak Vo2 without altering endothelial function or arterial stiffness. This suggests that other mechanisms, such as enhanced skeletal muscle perfusion and/or oxygen utilization, may be responsible for the ET-mediated increase in peak Vo2 in older HFPEF patients. (Prospective Aerobic Reconditioning Intervention Study [PARIS]; NCT01113840).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In older patients with HFpEF, the increased peak VO2 after moderate-intensity continuous endurance exercise training was secondary to peripheral adaptations that resulted in increased peak exercise AVO2 difference without a change in cardiovascular function.
“In older patients with HF with preserved ejection fraction, the increased peak V˙o2 after moderate-intensity continuous endurance exercise training was secondary to peripheral adaptations that resulted in increased peak exercise AV˙o2 difference without a change in cardiovascular function (ie, no change in peak exercise cardiac output, central artery stiffness, or peripheral arterial endothelial”
Modest weight loss caused by lifestyle interventions in obesity-related HFpEF patients improved exercise capacity but had no effect on cardiac structure or function.
“Several studies reported that (modest) weight loss caused by lifestyle interventions in obesity-related HFpEF patients improved exercise capacity but had no effect on cardiac structure or function.”
From The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF (2023) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1992) · PubMed · Cited by 33,716 · see citing works
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033 · see citing works
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. S., Charbonneau, F., Creager, M. A., Deanfield, J. E., Drexler, H., Gerhard‐Herman, M. D., Herrington, D. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,606 · see citing works
Self-citationTrends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction
Owan, T., Hodge, D. O., Herges, R. M., Jacobsen, S. J., Roger, V. L., & Redfield, M. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052256 · Cited by 4,191 · see citing works
Anderson, E. N. (1977) · Journal of California Anthropology, The · Cited by 2,550 · see citing works
Rich, M. W., Beckham, V., Wittenberg, C., Leven, C. L., Freedland, K. E., & Carney, R. M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511023331806 · Cited by 2,326 · see citing works
The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure.
Guyatt, G. H., Sullivan, M. J., Thompson, P. J., Fallen, E. L., Pugsley, S. O., Taylor, D. W., & Berman, L. (1985) · Europe PMC (PubMed Central) · Cited by 2,069 · see citing works
Wisløff, U., Støylen, A., Loennechen, J. P., Bruvold, M., Rognmo, Ø., Haram, P. M., Tjønna, A. E., Helgerud, J., Slørdahl, S. A., Lee, S. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675041 · Cited by 1,996 · see citing works
Nishimura, R. A., & Tajik, A. J. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00144-7 · Cited by 1,257 · see citing works
Celermajer, D. S., Sørensen, K. E., Bull, C., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90141-4 · Cited by 1,228 · see citing works
Exercise Hemodynamics Enhance Diagnosis of Early Heart Failure With Preserved Ejection Fraction
Borlaug, B. A., Nishimura, R. A., Sorajja, P., Lam, C. S. P., & Redfield, M. M. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.930701 · Cited by 1,119 · see citing works
Hambrecht, R., Fiehn, E., Weigl, C., Gielen, S., Hamann, C., Kaiser, R., Yu, J., Adams, V., Niebauer, J., & Schuler, G. C. (1998) · Circulation · doi:10.1161/01.cir.98.24.2709 · Cited by 963 · see citing works
Kawaguchi, M., Hay, I., Fetics, B. J., & Kass, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048123.22359.a0 · Cited by 929 · see citing works
Kitzman, D. W. (2002) · JAMA · doi:10.1001/jama.288.17.2144 · Cited by 883 · see citing works
Self-citationGlobal Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction
Borlaug, B. A., Olson, T. P., Lam, C. S. P., Flood, K. S., Lerman, A., Johnson, B. D., & Redfield, M. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.077 · Cited by 733 · see citing works
Borlaug, B. A., Melenovsky, V., Russell, S. D., Kessler, K., Pacak, K., Becker, L. C., & Kass, D. A. (2006) · Circulation · doi:10.1161/circulationaha.106.632745 · Cited by 699 · see citing works
Sullivan, M. J., Higginbotham, M. B., & Cobb, F. R. (1988) · Circulation · doi:10.1161/01.cir.78.3.506 · Cited by 697 · see citing works
Skeletal muscle biochemistry and histology in ambulatory patients with long-term heart failure.
Sullivan, M. J., Green, H. J., & Cobb, F. R. (1990) · Circulation · doi:10.1161/01.cir.81.2.518 · Cited by 689 · see citing works
Kitzman, D. W., Higginbotham, M. B., Cobb, F. R., Sheikh, K. H., & Sullivan, M. J. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90832-t · Cited by 683 · see citing works
Self-citationEdelmann, F., Gelbrich, G., Düngen, H., Fröhling, S., Wachter, R., Stahrenberg, R., Binder, L., Töpper, A., Lashki, D. J., Schwarz, S., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.054 · Cited by 677 · see citing works
Importance of heart failure with preserved systolic function in patients ≥65 years of age
Kitzman, D. W., Gardin, J. M., Gottdiener, J. S., Arnold, A. M., Boineau, R., Aurigemma, G., Marino, E. K., Lyles, M. F., Cushman, M., & Enright, P. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01393-x · Cited by 634 · see citing works
Self-citationPhysical Training Improves Endothelial Function in Patients With Chronic Heart Failure
Hornig, B., Maier, V., & Drexler, H. (1996) · Circulation · doi:10.1161/01.cir.93.2.210 · Cited by 628 · see citing works
Arterial Stiffness and the Development of Hypertension
Liao, D., Arnett, D. K., Tyroler, H. A., Riley, W. A., Chambless, L. E., Szklo, M., & HEISS, G. M. (1999) · Hypertension · doi:10.1161/01.hyp.34.2.201 · Cited by 544 · see citing works
Rector, T. S., Kubo, S. H., & Cohn, J. N. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90582-w · Cited by 504 · see citing works
Melenovský, V., Borlaug, B. A., Rosen, B. D., Hay, I., Ferrucci, L., Morell, C., Lakatta, E. G., Najjar, S. S., & Kass, D. A. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.050 · Cited by 482 · see citing works
Haykowsky, M. J., Brubaker, P. H., John, J. M., Stewart, K. P., Morgan, T. M., & Kitzman, D. W. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.02.055 · Cited by 447 · see citing works
Self-citationExercise Training in Older Patients With Heart Failure and Preserved Ejection Fraction
Kitzman, D. W., Brubaker, P. H., Morgan, T. M., Stewart, K. P., & Little, W. C. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.958785 · Cited by 410 · see citing works
Self-citationSkeletal Muscle Function and Its Relation to Exercise Tolerance in Chronic Heart Failure
Harrington, D., Anker, S. D., Chua, T. P., Webb-Peploe, K., Ponikowski, P. P., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00381-1 · Cited by 400 · see citing works
Hundley, W. G., Kitzman, D. W., Morgan, T. M., Hamilton, C. A., Darty, S. N., Stewart, K. P., Herrington, D. M., Link, K. M., & Little, W. C. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01447-4 · Cited by 386 · see citing works
Self-citationHambrecht, R., Fiehn, E., Yu, J., Niebauer, J., Weigl, C., Hilbrich, L., Adams, V., Riede, U., & Schuler, G. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00015-6 · Cited by 386 · see citing works
Molmen, H. E., Stølen, T., Tjønna, A. E., Aamot, I., Schjerve, I. E., Tyldum, G. A., Wisløff, U., Ingul, C. B., & Støylen, A. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711400512 · Cited by 369 · see citing works
Haykowsky, M. J., Brubaker, P. H., Stewart, K. P., Morgan, T. M., Eggebeen, J., & Kitzman, D. W. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.055 · Cited by 358 · see citing works
Self-citationEffects of Vasodilation in Heart Failure With Preserved or Reduced Ejection Fraction
Schwartzenberg, S., Redfield, M. M., From, A. M., Sorajja, P., Nishimura, R. A., & Borlaug, B. A. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.09.062 · Cited by 330 · see citing works
Hemodynamic Basis of Exercise Limitation in Patients With Heart Failure and Normal Ejection Fraction
Maeder, M. T., Thompson, B. R., Rocca, H. B., & Kaye, D. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.04.040 · Cited by 327 · see citing works
Linke, A. H.-P., Schoene, N., Gielen, S., Hofer, J., Erbs, S., Schuler, G. C., & Hambrecht, R. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01108-6 · Cited by 286 · see citing works
Mottram, P. M., Haluska, B. A., Leano, R., Cowley, D., Stowasser, M., & Marwick, T. H. (2004) · Circulation · doi:10.1161/01.cir.0000138680.89536.a9 · Cited by 278 · see citing works
Hambrecht, R., Hilbrich, L., Erbs, S., Gielen, S., Fiehn, E., Schoene, N., & Schuler, G. C. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00602-6 · Cited by 272 · see citing works
Abnormal Haemodynamic Response to Exercise in Heart Failure with Preserved Ejection Fraction
Bhella, P. S., Prasad, A., Heinicke, K., Hastings, J. L., Arbab-Zadeh, A., Adams-Huet, B., Pacini, E. L., Shibata, S., Palmer, M. D., Newcomer, B. R., et al. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr133 · Cited by 238 · see citing works
Erbs, S., Höllriegel, R., Linke, A., Beck, E. B., Adams, V., Gielen, S., Möbius‐Winkler, S., Sandri, M., Kränkel, N., Hambrecht, R., et al. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.868992 · Cited by 213 · see citing works
Pierce, G. L., Eskurza, I., Walker, A. E., Fay, T. N., & Seals, D. R. (2010) · Clinical Science · doi:10.1042/cs20100174 · Cited by 209 · see citing works
Skeletal muscle response to exercise training in congestive heart failure.
Minotti, J. R., Johnson, E. C., Hudson, T. L., Zuroske, G., Murata, G., Fukushima, E., Cagle, T. G., Chick, T. W., Massie, B. M., & Icenogle, M. V. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114771 · Cited by 204 · see citing works
Heart failure depresses endothelium-dependent responses in canine femoral artery
Kaiser, L., Spickard, R. C., & Olivier, N. B. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.256.4.h962 · Cited by 188 · see citing works
Herrington, D. M., Fan, L., Drum, M., Riley, W. A., Pusser, B. E., Crouse, J. R., Burke, G. L., McBurnie, M. A., Morgan, T. M., & Espeland, M. A. (2001) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182670100800512 · Cited by 187 · see citing works
Self-citationIsolated Quadriceps Training Increases Maximal Exercise Capacity in Chronic Heart Failure
Esposito, F., Reese, V., Shabetai, R., Wagner, P. D., & Richardson, R. S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.025 · Cited by 175 · see citing works
Katz, S. D., Yuen, J., Bijou, R., & LeJemtel, T. H. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.5.1488 · Cited by 164 · see citing works
Smart, N. A., Haluska, B. A., Jeffriess, L., & Leung, D. Y. (2012) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2012.00295.x · Cited by 155 · see citing works
Left ventricular diastolic filling in the elderly: the cardiovascular health study
Gardin, J. M., Arnold, A. M., Bild, D. E., Smith, V. E., Lima, J. A. C., Klopfenstein, H. S., & Kitzman, D. W. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00339-7 · Cited by 149 · see citing works
Self-citationKitzman, D. W., Hundley, W. G., Brubaker, P. H., Morgan, T. M., Moore, J. B., Stewart, K. P., & Little, W. C. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.898916 · Cited by 131 · see citing works
Self-citationFujimoto, N., Prasad, A., Hastings, J. L., Bhella, P. S., Shibata, S., Palmer, D., & Levine, B. D. (2012) · American Heart Journal · doi:10.1016/j.ahj.2012.06.028 · Cited by 129 · see citing works
Tartière-Kesri, L., Tartière, J., Logeart, D., Beauvais, F., & Solal, A. C. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.10.873 · Cited by 119 · see citing works
Kobayashi, N., Tsuruya, Y., Iwasawa, T., Ikeda, N., Hashimoto, S., Yasu, T., Ueba, H., Kubo, N., Fujii, M., Kawakami, M., et al. (2003) · Circulation Journal · doi:10.1253/circj.67.505 · Cited by 107 · see citing works
Endothelial dysfunction of hindquarter resistance vessels in experimental heart failure
Drexler, H., & Lü, W. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.262.6.h1640 · Cited by 105 · see citing works
Tyni-Lenné, R., Gordon, A., Europe, E., Jansson, E., & Sylven, C. (1998) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(98)90503-6 · Cited by 101 · see citing works
Kitzman, D. W., Herrington, D. M., Brubaker, P. H., Moore, J. B., Eggebeen, J., & Haykowsky, M. J. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.00163 · Cited by 100 · see citing works
Self-citationSmilde, T. J., van den Berkmortel, F. W. P. J., Boers, G. H. J., Wollersheim, H. C. H., de Boo, T., van Langen, H., & Stalenhoef, A. F. H. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.12.1958 · Cited by 99 · see citing works
Mohler, E. R., Gornik, H. L., Gerhard‐Herman, M. D., Misra, S., Olin, J. W., & Zierler, R. E. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.009 · Cited by 86 · see citing works
Relationship Between Arterial Stiffness and Subclinical Aortic Atherosclerosis
Herrington, D. M., Brown, W. V., Mosca, L. J., Davis, W. W., Eggleston, B. S., Hundley, W. G., & Raines, J. K. (2004) · Circulation · doi:10.1161/01.cir.0000136582.33493.cc · Cited by 79 · see citing works
Self-citationExercise training increases arterial compliance in patients with congestive heart failure
Parnell, M. M., Holst, D. P., & Kaye, D. M. (2001) · Clinical Science · doi:10.1042/cs1020001 · Cited by 77 · see citing works
Marburger, C., Brubaker, P. H., Pollock, W. E., Morgan, T. M., & Kitzman, D. W. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00502-5 · Cited by 75 · see citing works
Self-citationHaykowsky, M. J., Herrington, D. M., Brubaker, P. H., Morgan, T. M., Hundley, W. G., & Kitzman, D. W. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls099 · Cited by 71 · see citing works
Self-citationThe enthalpy of formation of thin film titanium disilicide
Kasica, R. J., & Cotts, E. J. (1997) · Journal of Applied Physics · doi:10.1063/1.365930 · Cited by 70 · see citing works
Exercise Training for Heart Failure
Coats, A. J. S. (1999) · Circulation · doi:10.1161/01.cir.99.9.1138 · Cited by 65 · see citing works
Vascular health in the ageing athlete
DeVan, A. E., & Seals, D. R. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.058792 · Cited by 46 · see citing works
Heart Failure with Preserved Ejection Fraction: Pathophysiology and Emerging Therapies
From, A. M., & Borlaug, B. A. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00133.x · Cited by 38 · see citing works
Reliability of Peak Exercise Testing in Patients With Heart Failure With Preserved Ejection Fraction
Scott, J. M., Haykowsky, M. J., Eggebeen, J., Morgan, T. M., Brubaker, P. H., & Kitzman, D. W. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.08.015 · Cited by 37 · see citing works
Self-citationPuntawangkoon, C., Kitzman, D. W., Kritchevsky, S. B., Hamilton, C. A., Nicklas, B. J., Leng, X., Brubaker, P. H., & Hundley, W. G. (2009) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-11-48 · Cited by 37 · see citing works
Self-citationExercise Intolerance in Heart Failure With Preserved Ejection Fraction
Maurer, M. S., & Schulze, P. C. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.012 · Cited by 29 · see citing works
Flagged first, then by citations
2 of the 69 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 19,618 · see citing works
2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab368 · Cited by 13,344 · see citing works
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429 · see citing works
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866 · see citing works
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862 · see citing works
2024 ESC Guidelines for the management of chronic coronary syndromes
Vrints, C. J., Andreotti, F., Koskinas, K. C., Rosselló, X., Adamo, M., Ainslie, J., BANNING, A. P., Budaj, A., Buechel, R. R., Chiariello, G. A., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae177 · Cited by 3,314 · see citing works
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001063 · Cited by 4,922 · see citing works
2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Authors/Task Force Members:, McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2333 · Cited by 2,274 · see citing works
Endothelial dysfunction and vascular disease - a 30th anniversary update
Vanhoutte, P. M., Shimokawa, H., Feletou, M., & Tang, E. H. C. (2017) · Acta Physiologica · doi:10.1111/apha.12646 · Cited by 937 · see citing works
Kitzman, D. W., Brubaker, P., Morgan, T., Haykowsky, M., Hundley, G., Kraus, W. E., Eggebeen, J., & Nicklas, B. J. (2016) · JAMA · doi:10.1001/jama.2015.17346 · Cited by 921 · see citing works
Self-citationTsutsui, H., Isobe, M., Ito, H., Ito, H., Okumura, K., Ōno, M., Kitakaze, M., Kinugawa, K., Kihara, Y., Goto, Y., et al. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0342 · Cited by 708 · see citing works
Ezekowitz, J. A., O'Meara, E., McDonald, M. A., Abrams, H., Chan, M., Ducharme, A., Giannetti, N., Grzeslo, A., Hamilton, P. G., Heckman, G. A., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.022 · Cited by 676 · see citing works
Epigenetic regulation of aging: implications for interventions of aging and diseases
Kang, W., Liu, H., Hu, Q., Wang, L., Liu, J., Zheng, Z., Zhang, W., Ren, J., Zhu, F., & Liu, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01211-8 · Cited by 694 · see citing works
Kittleson, M. M., Panjrath, G. S., Amancherla, K., Davis, L. L., Deswal, A., Dixon, D. L., Januzzi, J. L., & Yancy, C. W. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.03.393 · Cited by 554 · see citing works
Exercise-based cardiac rehabilitation for adults with heart failure
Long, L., Mordi, I. R., Bridges, C., Sagar, V. A., Davies, E. J., Coats, A. J. S., Dalal, H. M., Rees, K., Singh, S. J., & Taylor, R. S. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003331.pub5 · Cited by 558 · see citing works
Heart Failure With Preserved Ejection Fraction: Mechanisms, Clinical Features, and Therapies
Sharma, K., & Kass, D. A. (2014) · Circulation Research · doi:10.1161/circresaha.115.302922 · Cited by 508 · see citing works
Exercise Training in Patients With Heart Failure and Preserved Ejection Fraction
Pandey, A., Parashar, A., Kumbhani, D. J., Agarwal, S. K., Garg, J., Kitzman, D. W., Levine, B. D., Drazner, M. H., & Berry, J. D. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001615 · Cited by 504 · see citing works
Self-citationIkonomidis, I., Aboyans, V., Blacher, J., Brodmann, M., Brutsaert, D. L., Chirinos, J. A., Carlo, M. D., Delgado, V., Lancellotti, P., Lekakis, J. P., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1436 · Cited by 396 · see citing works
Cardiac Rehabilitation for Patients With Heart Failure
Bozkurt, B., Fonarow, G. C., Goldberg, L. R., Guglin, M. E., Josephson, R., Forman, D. E., Lin, G., Lindenfeld, J. M., O’Connor, C., Panjrath, G. S., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.030 · Cited by 375 · see citing works
Mueller, S., Winzer, E. B., Duvinage, A., Gevaert, A. B., Edelmann, F., Haller, B., Pieske-Kraigher, E., Beckers, P., Bobenko, A., Hommel, J., et al. (2021) · JAMA · doi:10.1001/jama.2020.26812 · Cited by 347 · see citing works
Self-citationAshor, A. W., Lara, J., Siervo, M., Celis-Morales, C. A., Oggioni, C., Jakovljević, D. G., & Mathers, J. C. (2014) · Sports Medicine · doi:10.1007/s40279-014-0272-9 · Cited by 347 · see citing works
Kitzman, D. W., Nicklas, B. J., Kraus, W. E., Lyles, M. F., Eggebeen, J., Morgan, T. M., & Haykowsky, M. J. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00004.2014 · Cited by 345 · see citing works
Self-citationDeveloping Therapies for Heart Failure With Preserved Ejection Fraction
Butler, J., Fonarow, G. C., Zile, M. R., Lam, C. S. P., Roessig, L., Schelbert, E. B., Shah, S. J., Ahmed, A., Bonow, R. O., Cleland, J. G. F., et al. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2013.10.006 · Cited by 325 · see citing works
Forman, D. E., Arena, R., Boxer, R., Dolansky, M. A., Eng, J. J., Fleg, J. L., Haykowsky, M., Jahangir, A., Kaminsky, L. A., Kitzman, D. W., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000483 · Cited by 319 · see citing works
Self-citationJCS/JACR 2021 Guideline on Rehabilitation in Patients With Cardiovascular Disease
Makita, S., Yasu, T., Akashi, Y. J., Adachi, H., Izawa, H., Ishihara, S., Iso, Y., Ohuchi, H., Omiya, K., Ohya, Y., et al. (2022) · Circulation Journal · doi:10.1253/circj.cj-22-0234 · Cited by 296 · see citing works
Angadi, S. S., Mookadam, F., Lee, C. D., Tucker, W. J., Haykowsky, M. J., & Gaesser, G. A. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00518.2014 · Cited by 262 · see citing works
Self-citationHaykowsky, M. J., Kouba, E., Brubaker, P. H., Nicklas, B. J., Eggebeen, J., & Kitzman, D. W. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.12.031 · Cited by 251 · see citing works
Self-citationMultidisciplinary Cardiac Rehabilitation and Long-Term Prognosis in Patients With Heart Failure
Kamiya, K., Sato, Y., Takahashi, T., Tsuchihashi‐Makaya, M., Kotooka, N., Ikegame, T., Takura, T., Yamamoto, T., Nagayama, M., Goto, Y., et al. (2020) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006798 · Cited by 232 · see citing works
Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial
Howden, E. J., Sarma, S., Lawley, J. S., Opondo, M. A., Cornwell, W. K., Stoller, D. A., Urey, M. A., ADAMS-HUET, B. A., & Levine, B. D. (2018) · Circulation · doi:10.1161/circulationaha.117.030617 · Cited by 217 · see citing works
IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction
Tassell, B. W. V., Trankle, C. R., Canada, J. M., Carbone, S., Buckley, L. F., Kadariya, D., Buono, M. G. D., Billingsley, H., Wohlford, G. F., Viscusi, M. M., et al. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.118.005036 · Cited by 214 · see citing works
Molina, A. J. A., Bharadwaj, M. S., Horn, C. V., Nicklas, B. J., Lyles, M. F., Eggebeen, J., Haykowsky, M. J., Brubaker, P. H., & Kitzman, D. W. (2016) · JACC Heart Failure · doi:10.1016/j.jchf.2016.03.011 · Cited by 209 · see citing works
Self-citation2024 Clinical practice guidelines for Chronic heart failure
Galyavich, A. S., Tereshchenko, S. N., Uskach, T. M., Ageev, F. T., Aronov, D. M., Arutyunov, G. P., Begrambekova, Y. L., Belenkov, Y. N., Boytsov, S. A., Bubnova, M. G., et al. (2024) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2024-6162 · Cited by 251 · see citing works
Eggebeen, J., Kim-Shapiro, D. B., Haykowsky, M., Morgan, T. M., Basu, S., Brubaker, P., Rejeski, J., & Kitzman, D. W. (2016) · JACC: Heart Failure · doi:10.1016/j.jchf.2015.12.013 · Cited by 190 · see citing works
Self-citationCardiac Rehabilitation Exercise and Self-Care for Chronic Heart Failure
Ades, P. A., Keteyian, S. J., Balady, G. J., Miller, N. H., Kitzman, D. W., MANCINI, D. M., & Rich, M. W. (2013) · JACC Heart Failure · doi:10.1016/j.jchf.2013.09.002 · Cited by 190 · see citing works
Self-citationHeart failure with preserved ejection fraction
HAMO, C. E., DeJong, C., Hartshorne‐Evans, N., Lund, L. H., Shah, S. J., Solomon, S. D., & Lam, C. S. P. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00540-y · Cited by 180 · see citing works
Health benefits of aerobic training programs in adults aged 70 and over: a systematic review
Bouaziz, W., Vogel, T., Schmitt, E., Kaltenbach, G., Gény, B., & Lang, P. O. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2016.10.012 · Cited by 175 · see citing works
Bowen, T. S., Rolim, N. P. L., Fischer, T., Bækkerud, F. H., Medeiros, A., Werner, S., Brønstad, E., Rognmo, O., Mangner, N., Linke, A., et al. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.239 · Cited by 165 · see citing works
Heart Failure With Preserved Ejection Fraction
Reddy, Y. N. V., & Borlaug, B. A. (2015) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2015.12.002 · Cited by 158 · see citing works
Exercise training in chronic heart failure: improving skeletal muscle O2transport and utilization
Hirai, D. M., Musch, T. I., & Poole, D. C. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00469.2015 · Cited by 159 · see citing works
Heart failure with preserved ejection fraction in the elderly: scope of the problem
Upadhya, B., Taffet, G. E., Cheng, C. P., & Kitzman, D. W. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.02.025 · Cited by 156 · see citing works
Self-citationMyocardial hypertrophy and its role in heart failure with preserved ejection fraction
Heinzel, F. R., Hohendanner, F., Jin, G., Sedej, S., & Edelmann, F. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00374.2015 · Cited by 153 · see citing works
Lim, S. L., Lam, C. S. P., Segers, V. F. M., Brutsaert, D. L., & Keulenaer, G. W. D. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv132 · Cited by 149 · see citing works
Fukuta, H., Goto, T., Wakami, K., Kamiya, T., & Ohte, N. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09774-5 · Cited by 149 · see citing works
Heart failure with preserved ejection fraction: New approaches to diagnosis and management
Upadhya, B., & Kitzman, D. W. (2019) · Clinical Cardiology · doi:10.1002/clc.23321 · Cited by 147 · see citing works
Self-citationPugliese, N. R., Pellicori, P., Filidei, F., Biase, N. D., Maffia, P., Guzik, T. J., Masi, S., Taddei, S., & Cleland, J. G. F. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac133 · Cited by 149 · see citing works
Kaye, D. M., Shah, S. J., Borlaug, B. A., Gustafsson, F., Komtebedde, J., Kubo, S. H., Magnin, C., Maurer, M. S., Feldman, T. E., & Burkhoff, D. (2014) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.01.005 · Cited by 142 · see citing works
Heart Failure With Preserved Ejection Fraction: A Review of Cardiac and Noncardiac Pathophysiology
Gevaert, A. B., Boen, J. R. A., Segers, V. F. M., & Craenenbroeck, E. M. V. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00638 · Cited by 134 · see citing works
Sachdev, V., Sharma, K., Keteyian, S. J., Alcain, C. F., Desvigne-Nickens, P. M., Fleg, J. L., Florea, V. G., Franklin, B. A., Guglin, M. E., Halle, M., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001122 · Cited by 136 · see citing works
Self-citationGuía ESC 2021 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.11.027 · Cited by 132 · see citing works
Pearson, M. J., & Smart, N. A. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.12.145 · Cited by 123 · see citing works
Epidemiology of Heart Failure with Preserved Ejection Fraction
Dhingra, A., Garg, A., Kaur, S., Chopra, S., Batra, J. S., Pandey, A., Chaanine, A. H., & Agarwal, S. K. (2014) · Current Heart Failure Reports · doi:10.1007/s11897-014-0223-7 · Cited by 121 · see citing works
Lang, C. C., Smith, K. T., Wingham, J., Eyre, V., Greaves, C. J., Warren, F. C., Green, C., Jolly, K. B., Davis, R., Doherty, P., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019649 · Cited by 118 · see citing works
Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Borlaug, B. A. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-1103 · Cited by 116 · see citing works
Rethinking Endothelial Dysfunction as a Crucial Target in Fighting Heart Failure
Premer, C., Kanelidis, A., Hare, J. M., & Schulman, I. H. (2019) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2018.12.006 · Cited by 114 · see citing works
von Haehling, S., Arzt, M. E., Doehner, W., Edelmann, F., Evertz, R., Ebner, N., Herrmann‐Lingen, C., Garfias‐Veitl, T., Koziolek, M. J., Noutsias, M., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1838 · Cited by 116 · see citing works
Scandalis, L., Kitzman, D. W., Nicklas, B. J., Lyles, M. F., Brubaker, P. H., Nelson, M. B., Gordon, M., Stone, J., Bergstrom, J., Neufer, P. D., et al. (2023) · JAMA Cardiology · doi:10.1001/jamacardio.2023.0957 · Cited by 112 · see citing works
Self-citationSandri, M., Viehmann, M., Adams, V., Rabald, K., Mangner, N., Höllriegel, R., Lurz, P. C., Erbs, S., Linke, A., Kirsch, K., et al. (2015) · European Journal of Preventive Cardiology · doi:10.1177/2047487315588391 · Cited by 110 · see citing works
Fukuta, H., Goto, T., Wakami, K., & Ohte, N. (2014) · European Journal of Preventive Cardiology · doi:10.1177/2047487314564729 · Cited by 109 · see citing works
Hegde, S. M., Claggett, B., Shah, A., Lewis, E., Anand, I., Shah, S. J., Sweitzer, N., Fang, J. C., Pitt, B., Pfeffer, M., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.028002 · Cited by 96 · see citing works
da Silveira, A. D., de Lima, J. B., Piardi, D. S., Macedo, D. D. S., Zanini, M., Nery, R. M., Laukkanen, J. A., & Stein, R. (2020) · European Journal of Preventive Cardiology · doi:10.1177/2047487319901206 · Cited by 107 · see citing works
Heart failure with preserved ejection fraction: Refocusing on diastole
Abbate, A., Arena, R. A., Abouzaki, N. A., Tassell, B. W. V., Canada, J. M., Shah, K. B., Biondi‐Zoccai, G., & Voelkel, N. F. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.106 · Cited by 101 · see citing works
Impact of Physical Inactivity on Mortality in Patients With Heart Failure
Doukky, R., Mangla, A., Ibrahim, Z., Poulin, M., Avery, E., Collado, F., Kaplan, J., Richardson, D., & Powell, L. H. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.12.060 · Cited by 101 · see citing works
Hussain, S. R., Macaluso, A., & Pearson, S. J. (2016) · Cardiology in Review · doi:10.1097/crd.0000000000000124 · Cited by 95 · see citing works
von Haehling, S., Doehner, W., Evertz, R., Garfias‐Veitl, T., Derad, C., Diek, M., Karakas, M., Birkemeyer, R., Fillippatos, G., Lainščak, M., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae479 · Cited by 95 · see citing works
Upadhya, B., Pisani, B., & Kitzman, D. W. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15141 · Cited by 93 · see citing works
Self-citationZhang, Y., Qi, L., Xu, L., Sun, X., Liu, W., Zhou, S., van de Vosse, F. N., & Greenwald, S. E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200829 · Cited by 93 · see citing works
Exercise effects on cardiovascular disease: from basic aspects to clinical evidence
Sanchis‐Gomar, F., Lavie, C. J., Marín-Puyalto, J., Pérez-Quilis, C., Eijsvogels, T. M. H., O’Keefe, J. H., Perez, M. V., & Blair, S. N. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab272 · Cited by 99 · see citing works
Dieberg, G., Ismail, H., Giallauria, F., & Smart, N. A. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00904.2014 · Cited by 92 · see citing works
Alem, M. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133198 · Cited by 92 · see citing works
Mentz, R. J., Whellan, D. J., Reeves, G. R., Pastva, A. M., Duncan, P. W., Upadhya, B., Nelson, M. B., Chen, H., Reed, S. D., Rosenberg, P. B., et al. (2021) · JACC Heart Failure · doi:10.1016/j.jchf.2021.05.007 · Cited by 95 · see citing works
Self-citationVanfleteren, L. E. G. W., Spruit, M. A., Groenen, M. T. J., Bruijnzeel, P. L. B., Taib, Z., Rutten, E. P. A., Roodt, J. O. ’., Akkermans, M. A., Wouters, E. F. �., & Franssen, F. M. E. (2013) · European Respiratory Journal · doi:10.1183/09031936.00169313 · Cited by 91 · see citing works
Exercise intolerance in heart failure with preserved ejection fraction: more than a heart problem.
Upadhya, B., Haykowsky, M. J., Eggebeen, J., & Kitzman, D. W. (2015) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2015.03.013 · Cited by 98 · see citing works
Self-citationDeterminants of Effort Intolerance in Patients With Heart Failure
Shimiaie, J., Sherez, J., Aviram, G., Megidish, R., Viskin, S., Halkin, A., Ingbir, M., Nesher, N., Biner, S., Keren, G., et al. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.05.010 · Cited by 87 · see citing works
Shaltout, H. A., Eggebeen, J., Marsh, A. P., Brubaker, P. H., Laurienti, P. J., Burdette, J. H., Basu, S., Morgan, A. R., Santos, P. C. D., Norris, J. L., et al. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.05.005 · Cited by 82 · see citing works
Self-citationEndothelial Dysfunction in COVID-19: A Unifying Mechanism and a Potential Therapeutic Target
Ambrosino, P., Calcaterra, I. L., Mosella, M., Formisano, R., D’Anna, S. E., Bachetti, T., Marcuccio, G., Galloway, B., Mancini, F. P., Papa, A., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10040812 · Cited by 81 · see citing works
Kajikawa, M., Maruhashi, T., Hida, E., Iwamoto, Y., Matsumoto, T., Iwamoto, A., Oda, N., Kishimoto, S., Matsui, S., Hidaka, T., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06839 · Cited by 80 · see citing works
Abudureyimu, M., Luo, X., Wang, X., Sowers, J. R., Wang, W., Ge, J., Ren, J. T., & Zhang, Y. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac028 · Cited by 82 · see citing works
Upadhya, B., Haykowsky, M. J., Eggebeen, J., & Kitzman, D. W. (2015) · Current Heart Failure Reports · doi:10.1007/s11897-015-0257-5 · Cited by 79 · see citing works
Self-citationHeart Failure: Exercise-Based Cardiac Rehabilitation: Who, When, and How Intense?
Haykowsky, M. J., Daniel, K. M., Bhella, P. S., Sarma, S., & Kitzman, D. W. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.06.001 · Cited by 76 · see citing works
Self-citationThe cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF
Withaar, C., Meems, L. M. G., Nollet, E. E., Schouten, E. M., Schroeder, M. A., Knudsen, L. B., Niss, K., Madsen, C. T., Hoegl, A., Mazzoni, G., et al. (2023) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2023.05.012 · Cited by 74 · see citing works
Zotter‐Tufaro, C., Mascherbauer, J., Duca, F., Koell, B., Aschauer, S., Kammerlander, A. A., Panzenboeck, A., Sadushi‐Kolici, R., Bangert, C., Laimer, D., et al. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.01.010 · Cited by 74 · see citing works
Tucker, W. J., Lijauco, C. C., Hearon, C. M., Angadi, S. S., Nelson, M. D., Sarma, S., Nanayakkara, S., Gerche, A. L., & Haykowsky, M. J. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.07.002 · Cited by 72 · see citing works
Self-citationMoe, G. W. P. L., Ezekowitz, J. A., O’Meara, E., Howlett, J. G., Fremes, S. E., Al‐Hesayen, A., Heckman, G. A., Ducharme, A., Estrella-Holder, E., Grzeslo, A., et al. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2013.10.010 · Cited by 68 · see citing works
Heart Failure with Preserved Ejection Fraction in Older Adults
Upadhya, B., & Kitzman, D. W. (2017) · Heart Failure Clinics · doi:10.1016/j.hfc.2017.02.005 · Cited by 68 · see citing works
Self-citationExercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy
Ma, L., Li, K., Wei, W., Zhou, J., Li, Z., Zhang, T., Wangsun, Y., Tian, F., Dong, Q., Zhang, H., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102693 · Cited by 67 · see citing works
Chan, E., Giallauria, F., Vigorito, C., & Smart, N. A. (2016) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2016.759 · Cited by 66 · see citing works
Huang, C., Wang, J., Deng, S., She, Q., & Wu, L. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12495 · Cited by 65 · see citing works
Exercise Physiology in Heart Failure and Preserved Ejection Fraction
Haykowsky, M. J., & Kitzman, D. W. (2014) · Heart Failure Clinics · doi:10.1016/j.hfc.2014.04.001 · Cited by 64 · see citing works
Self-citationEffect of Aerobic Exercise Training on Arterial Stiffness in Obese Populations
Montero, D., Roberts, C. K., & Vinet, A. (2014) · Sports Medicine · doi:10.1007/s40279-014-0165-y · Cited by 63 · see citing works
The Effects of Exercise Training on Brachial Artery Flow-Mediated Dilation
Early, K. S., Stewart, A., Johannsen, N. M., Lavie, C. J., Thomas, J. R., & Welsch, M. A. (2016) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000206 · Cited by 63 · see citing works
Targeting obesity and diabetes to treat heart failure with preserved ejection fraction
Altara, R., Giordano, M., Nordén, E. S., Cataliotti, A., Kurdi, M., Bajestani, S. N., & Booz, G. W. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00160 · Cited by 61 · see citing works
Pandey, A., Kitzman, D. W., Brubaker, P. H., Haykowsky, M. J., Morgan, T. M., Becton, J. T., & Berry, J. D. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14867 · Cited by 62 · see citing works
Self-citationOikonomou, E. K., Vogiatzi, G., Karlis, D., Siasos, G., Chrysohoou, C. A., Zografos, T. A., Lazaros, G. A., Tsalamandris, S., Mourouzis, K., Georgiopoulos, G. A., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.04.017 · Cited by 61 · see citing works
Gevaert, A. B., Lemmens, K., Vrints, C. J., & Craenenbroeck, E. M. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4865756 · Cited by 60 · see citing works
Tsigkou, V., Oikonomou, E. K., Anastasiou, A., Lampsas, S., Zakynthinos, G. Ε., Kalogeras, K. I., Katsioupa, M., Kapsali, M., Kourampi, I., Pesiridis, T., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054321 · Cited by 64 · see citing works
Edelmann, F., Wachter, R., Duvinage, A., Mueller, S., Fegers‐Wustrow, I., Schwarz, S., Christle, J. W., Pieske‐Kraigher, E., Seyfarth, M., Knapp, M., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03342-7 · Cited by 59 · see citing works
Self-citationEdelmann, F., Feuerstein, A., Gelbrich, G., Hasenfuss, G. P., Herrmann‐Lingen, C., Duvinage, A., Schwarz, S., Mende, M., Prettin, C., Trippel, T. D., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.862 · Cited by 58 · see citing works
Hajj, E. C. E., Hajj, M. C. E., Sykes, B., Lamicq, M., Zile, M. R., Malcolm, R., O’Neil, P. M., & Litwin, S. E. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022930 · Cited by 57 · see citing works
Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies
Ya, J., & Bayraktutan, U. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411538 · Cited by 57 · see citing works
Leggio, M., Fusco, A., Loreti, C., Limongelli, G., Bendini, M. G., Mazza, A., Coraci, D., & Padua, L. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09841-x · Cited by 56 · see citing works
- Authors
- Kitzman, D. W., Brubaker, P. H., Herrington, D. M., Morgan, T. M., Stewart, K. P., Hundley, W. G., Abdelhamed, A., & Haykowsky, M. J.
- Affiliations
- Wake Forest University Health Sciences (US)
- Wake Forest University (US)
- Wright State University (US)
- University of Alberta (CA)
- Corresponding author
- Kitzman, Dalane W.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 62
- Issue
- 7
- Pages
- 584-592
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC3740089
- OpenAlex
- W113644040
- Cited by
- 369
- References
- 69
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 21 · 2023: 33 · 2022: 39 · 2021: 32 · 2020: 18 · 2019: 30 · 2018: 25 · 2017: 35 · 2016: 24 · 2015: 32 · 2014: 31 · 2013: 7
- FWCI
- 74.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R37AG18915, R01AG12257, and P30AG021332)
- Novartis
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- heart failure with preserved ejection fraction, endurance training, endothelial function, flow-mediated dilation, arterial stiffness, carotid distensibility, older adults, quality of life, left ventricular function, skeletal muscle perfusion, ergometry, attentional control
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Angiography, Carotid Arteries, Endothelium, Vascular, Exercise Therapy, Female, Follow-Up Studies, Heart Failure, Humans, Male, Oxygen Consumption, Prospective Studies, Quality of Life, Reference Values, Severity of Illness Index, Stroke Volume, Ultrasonography, Single-Blind Method, Ventricular Function, Left, Treatment Outcome, Exercise Tolerance, Risk Assessment, Vascular Stiffness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
