The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains
Abstract
The goal of this study was to characterize the genetic contribution to both forced and voluntary exercise performance and to determine whether performance in these two paradigms is controlled by similar genetic influences. There were marked strain differences in treadmill exercise performance, with Swiss Webster (SW) and FVB/NJ mice showing elevated performance and C57BL/6J animals showing decreased performance compared with all other strains. There was no apparent relationship between treadmill performance and voluntary wheel performance, with the exception of SW mice, which demonstrated high performances on both the treadmill and the voluntary wheel. Numerous properties were measured to attempt to understand the basis for these differences in exercise performance. DBA/1J and SW mice exhibited significantly greater cardiac contractility than all other analyzed strains. Conversely, BALB/cByJ mice exhibited significantly reduced cardiac contractility compared with all other strains. Expression of molecular indicators of hypertrophy (atrial natriuretic factor and β-myosin heavy chain) was significantly elevated in DBA/2J myocardium compared with all other analyzed strains.
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Cites
Bouchard, C., An, P., Rice, T., Skinner, J. S., Wilmore, J. H., Gagnon, J., Pérusse, L., Leon, A. S., & Rao, D. C. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.3.1003 · Cited by 875
Cited by
Physical activity and resting metabolic rate
Speakman, J. R., & Selman, C. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2003282 · Cited by 441
Scheduled exercise phase shifts the circadian clock in skeletal muscle
WOLFF, G., & ESSER, K. A. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318255cf4c · Cited by 291
Voluntary wheel running: patterns and physiological effects in mice
Manzanares, G., Brito-da-Silva, G., & Gandra, P. G. (2019) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20187830 · Cited by 194
“In a study analyzing different inbred mouse strains, it was observed that C57BL/6J mice run significantly more and at a higher average speed, compared to six other strains (14).”
BackgroundNovel quantitative phenotypes of exercise training in mouse models
De Bono, J. P., Adlam, D., Paterson, D. J., & Channon, K. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00694.2005 · Cited by 197
Design of aging intervention studies: the NIA interventions testing program
Nadon, N. L., Strong, R., Miller, R. A., Nelson, J., Javors, M., Sharp, Z. D., Peralba, J. M., & Harrison, D. E. (2008) · AGE · doi:10.1007/s11357-008-9048-1 · Cited by 142
Metadata
- Authors
- Lerman, I., Harrison, B. C., Freeman, K., Hewett, T. E., Allen, D. L., Robbins, J., & Leinwand, L. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2002-06-01
- Volume
- 92
- Issue
- 6
- Pages
- 2245-2255
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2168456856
- Cited by
- 271
- References
- 1
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
