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Design of aging intervention studies: the NIA interventions testing program
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The enteric coating increased the fraction of rapamycin that survived food preparation by 3- to 4-fold and protected the agent from digestion in the stomach.
“This coating increased the fraction of rapamycin that survived the food preparation process by 3- to 4-fold, and protected the agent from digestion in the stomach16.”
From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [16]
The National Institute on Aging Interventions Testing Program (ITP) evaluates agents that may delay ageing and increase lifespan in genetically heterogeneous mice.
“The National Institute on Aging Interventions Testing Program (ITP) evaluates agents that may delay ageing and increase lifespan in genetically heterogeneous mice15–17.”
From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [16]
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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · cited 1×
“Resveratrol is a potent sirtuin stimulator and it also reduces acute inflammation in vivo and free radicals and mutations in vitro, inhibits tumor generation in response to the DMBA carcinogen, and protects against early death from injected neuroblastoma cells (Jang et al. 1997; Chen et al. 2004).”
BackgroundResveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868
Influence of TOR kinase on lifespan in C. elegans
Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057
Genotype and age influence the effect of caloric intake on mortality in mice
Forster, M. J., Morris, P., & Sohal, R. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0533fje · Cited by 236
Genetic differences in effects of food restriction on aging in mice
Harrison, D. E., & Archer, J. R. (1987) · The Journal of Nutrition · doi:10.1093/jn/117.2.376 · Cited by 133
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Metadata
- Authors
- Nadon, N. L., Strong, R., Miller, R. A., Nelson, J., Javors, M., Sharp, Z. D., Peralba, J. M., & Harrison, D. E.
- Venue
- AGE
- Published
- 2008-04-18
- Volume
- 30
- Issue
- 4
- Pages
- 187-199
- ISSN
- 0161-9152
- 1574-4647
- Cited by
- 142
- References
- 7
- Language
- en
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