Acute cardiac effects of marathon running
Abstract
We sought to clarify the significance of cardiac dysfunction and to assess its relationship with elevated biomarkers by using cardiovascular magnetic resonance imaging in healthy, middle-aged subjects immediately after they ran 26.2 miles. Cardiac dysfunction and elevated blood markers of myocardial injury have been reported after prolonged strenuous exercise. From 425 volunteers, 13 women and 12 men were randomly selected, provided medical and training history, and underwent baseline cardiopulmonary exercise testing to exhaustion. Blood biomarkers, cardiovascular magnetic resonance imaging, and 24-h ambulatory electrocardiography were performed 4 wk before and immediately after the race. Participants were 38.7+/-9.0 yr old, had baseline peak oxygen consumption of 52.9+/-5.6 ml.kg(-1).min(-1), and completed the marathon in 256.2+/-43.5 min. Cardiac troponin I and B-type natriuretic peptide increased following the race (P=0.001 and P<0.0001, respectively). Cardiovascular magnetic resonance-determined pre- and postmarathon left ventricular ejection fractions were comparable, 57.7+/-4.1% and 58.7+/-4.3%, respectively (P=0.32). Right atrial volume index increased from 46.7+/-14.4 to 57.0+/-14.5 ml/m2 (P<0.0001). Similarly, right ventricular end-systolic volume index increased from 47.4+/-11.2 to 57.0+/-14.6 ml/m2 (P<0.0001) whereas the right ventricular ejection fraction dropped from 53.6+/-7.1 to 45.5+/-8.5% (P<0.0001). There were no morphological changes observed in the left at…
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Right ventricular function may be more profoundly affected by intense endurance exercise than left ventricular function.
“However, right ventricular (RV) function may be more profoundly affected by intense endurance exercise 6 -10”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [7]
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Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes
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- Authors
- Trivax, J. E., Franklin, B. A., Goldstein, J. A., Chinnaiyan, K. M., Gallagher, M. J., deJong, A. T., Colar, J. M., Haines, D. E., & McCullough, P. A.
- Affiliations
- Beaumont Health (US)
- Corresponding author
- Trivax, Justin E.
- ORCID
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2010-05
- Volume
- 108
- Issue
- 5
- Pages
- 1148-1153
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2156661323
- Cited by
- 229
- References
- 5
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 15 · 2021: 11 · 2020: 15 · 2019: 15 · 2018: 11 · 2017: 9 · 2016: 21 · 2015: 28 · 2014: 26 · 2013: 10 · 2012: 26
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- marathon running, exercise-induced cardiac dysfunction, myocardial injury biomarkers, cardiac troponin I, brain natriuretic peptide, right ventricular ejection fraction, right atrial dilatation, right ventricular end-systolic volume, left ventricular ejection fraction, late gadolinium enhancement, exercise-induced arrhythmia, endurance exercise
- MeSH terms
- Adaptation, Physiological, Adult, Exercise Test, Female, Heart Atria, Heart Ventricles, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Oxygen Consumption, Physical Endurance, Running, Stroke Volume, Time Factors, Biomarkers, Electrocardiography, Ambulatory, Ventricular Function, Left, Ventricular Function, Right, Ventricular Dysfunction, Right, Troponin I, Natriuretic Peptide, Brain, Young Adult
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