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Cited by 346

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans

Cooke, William H., Ryan, Kathy L., Convertino, Victor A.·2004·Journal of Applied Physiology
DOI 10.1152/japplphysiol.01155.2003
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Abstract

Hemorrhage is a leading cause of death in both civilian and battlefield trauma. Survival rates increase when victims requiring immediate intervention are correctly identified in a mass-casualty situation, but methods of prioritizing casualties based on current triage algorithms are severely limited. Development of effective procedures to predict the magnitude of hemorrhage and the likelihood for progression to hemorrhagic shock must necessarily be based on carefully controlled human experimentation, but controlled study of severe hemorrhage in humans is not possible. It may be possible to simulate hemorrhage, as many of the physiological compensations to acute hemorrhage can be mimicked in the laboratory by applying negative pressure to the lower extremities. Lower body negative pressure (LBNP) sequesters blood from the thorax into dependent regions of the pelvis and legs, effectively decreasing central blood volume in a similar fashion as acute hemorrhage. In this review, we compare physiological responses to hemorrhage and LBNP with particular emphasis on cardiovascular compensations that both share in common. Through evaluation of animal and human data, we present evidence that supports the hypothesis that LBNP, and resulting volume sequestration, is an effective technique to study physiological responses and mechanisms associated with acute hemorrhage in humans. Such experiments could lead to clinical algorithms that identify bleeding victims who will likely progress to hemorrhagic shock and require lifesaving intervention(s).

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Metadata

Authors
Cooke, W. H., Ryan, K. L., & Convertino, V. A.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2004-04
Volume
96
Issue
4
Pages
1249-1261
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.01155.2003
OpenAlex
W2151499534
Cited by
346
References
94
FWCI
7.55
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans. https://app.cochat.ai/papers/10.1152/japplphysiol.01155.2003
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Cooke, W. H., Ryan, K. L., & Convertino, V. A. (2004). Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.01155.2003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.