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Cited by 47Renin-Angiotensin System StudiesSpaceflight effects on biologyNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Blockade of AT1 receptor partially restores vasoreactivity, NOS expression, and superoxide levels in cerebral and carotid arteries of hindlimb unweighting rats

Zhang, Ran, Bai, Yun-Gang, Lin, Le-Jian, Bao, Jun-Xiang, Zhang, Yu-Yang, Tang, Hao, Cheng, Jiu-Hua, Jia, Guo-Liang, Ren, Xin-Ling, Ma, Jin·2009·Journal of Applied Physiology
DOI 10.1152/japplphysiol.01278.2007
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Abstract

Previous studies have demonstrated activation of the local renin-angiotensin system in hindlimb unweighting (HU) rat vasculature. The present study intended to identify the effects of blockade of angiotensin II (ANG II) type 1 (AT(1)) receptors with losartan on vascular reactivity, nitric oxide synthase (NOS) expression, and superoxide anion (O(2)(*-)) levels in 3-wk HU rat cerebral and carotid arteries. Three weeks later, vasoconstriction, vasodilatation, endothelial NOS (eNOS) and inducible NOS (iNOS) protein, as well as O(2)(*-) levels in rat cerebral and carotid arteries were examined. We found that HU enhanced maximal response to KCl/5-hydroxytryptamine (P < 0.01) in basilar arteries and KCl/phenylephrine (P < 0.05) in common carotid arteries from HU rats. Acetylcholine induced concentration-dependent vasodilatation in all the artery rings, but with significantly smaller amplitude in basilar (P < 0.01) and common carotid (P < 0.05) arteries from HU rats than those from control rats. Chronic treatment with losartan partially restored response to vasoconstrictors and acetylcholine-induced vasodilatation in basilar (P < 0.01) and common carotid (P < 0.05) arteries from losartan-treated HU rats. Furthermore, iNOS content in cerebral arteries and eNOS/iNOS content in carotid arteries were significantly (P < 0.01) increased in HU rats. Meanwhile, HU increased O(2)(*-) levels in all the layers of these arteries. However, losartan restored NOS content and O(2)(*-) levels toward…

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Metadata

Authors
Zhang, R., Bai, Y.-G., Lin, L.-J., Bao, J.-X., Zhang, Y.-Y., Tang, H., Cheng, J.-H., Jia, G.-L., Ren, X.-L., & Ma, J.
Affiliations
Xijing Hospital (CN)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2009-01
Volume
106
Issue
1
Pages
251-258
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.01278.2007
OpenAlex
W2101628196
Cited by
47
References
2
Citations by year
2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 7 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 1
FWCI
2.43
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords
angiotensin II type 1 receptor, losartan, hindlimb unloading, microgravity, cerebral arteries, carotid artery, local renin-angiotensin system, nitric oxide synthase, inducible nitric oxide synthase, endothelial NOS, superoxide, vasoconstriction, vasodilation, acetylcholine, endothelium-dependent relaxation
MeSH terms
Angiotensin II, Animals, Basilar Artery, Dose-Response Relationship, Drug, Male, Renin-Angiotensin System, Superoxides, Vasoconstriction, Vasoconstrictor Agents, Vasodilation, Vasodilator Agents, Rats, Sprague-Dawley, Carotid Artery, Common, Oxidative Stress, Weightlessness Simulation, Nitric Oxide Synthase, Hindlimb Suspension, Losartan, Models, Animal, Receptor, Angiotensin, Type 1, Angiotensin II Type 1 Receptor Blockers, Rats, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III

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