Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839 · see citing works

Nitric oxide: an endogenous modulator of leukocyte adhesion.

Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,052 · see citing works

NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease

Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886 · see citing works

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735 · see citing works

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C. J., Reed, R. R., & Snyder, S. H. (1991) · Nature · doi:10.1038/351714a0 · Cited by 2,354 · see citing works

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154 · see citing works

Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484 · see citing works

A Stable Nonfluorescent Derivative of Resorufin for the Fluorometric Determination of Trace Hydrogen Peroxide: Applications in Detecting the Activity of Phagocyte NADPH Oxidase and Other Oxidases

Zhou, M., Diwu, Z. J., Panchuk-Voloshina, N., & Haugland, R. P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2391 · Cited by 1,400 · see citing works

Targeted disruption of the neuronal nitric oxide synthase gene

Huang, P. L., Dawson, T. M., Bredt, D. S., Snyder, S. H., & Fishman, M. C. (1993) · Cell · doi:10.1016/0092-8674(93)90615-w · Cited by 1,303 · see citing works

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells

Marui, N., Offermann, M. K., Swerlick, R., Kunsch, C., Rosen, C. A., Ahmad, M., Alexander, R. W., & Medford, R. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116778 · Cited by 1,072 · see citing works

Elevated blood pressures in mice lacking endothelial nitric oxide synthase

Shesely, E. G., Maeda, N., Kim, H.-S., Desai, K. M., Krege, J. H., Laubach, V. E., Sherman, P. A., Sessa, W. C., & Smithies, O. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13176 · Cited by 914 · see citing works

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

Laursen, J. B., Rajagopalan, S., Galis, Z. S., Tarpey, M. M., Freeman, B. Α., & Harrison, D. G. (1997) · Circulation · doi:10.1161/01.cir.95.3.588 · Cited by 820 · see citing works

Hypertension and the Pathogenesis of Atherosclerosis

Alexander, R. W. (1995) · Hypertension · doi:10.1161/01.hyp.25.2.155 · Cited by 785 · see citing works

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

Ushio‐Fukai, M., Zafari, A. M., Fukui, T., Ishizaka, N., & Griendling, K. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23317 · Cited by 766 · see citing works

Oxidant Signaling in Vascular Cell Growth, Death, and Survival

Irani, K. (2000) · Circulation Research · doi:10.1161/01.res.87.3.179 · Cited by 748 · see citing works

Does superoxide underlie the pathogenesis of hypertension?

Nakazono, K., Watanabe, N., Matsuno, K., Sasaki, J., Sato, T., & Inoue, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10045 · Cited by 746 · see citing works

Lewis A. Conner Memorial Lecture

Steinberg, D. H. (1997) · Circulation · doi:10.1161/01.cir.95.4.1062 · Cited by 743 · see citing works

Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin

Laursen, J. B., Somers, M., Kurz, S., McCann, L., Warnholtz, A., Freeman, B. A., Tarpey, M., Fukai, T., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.9.1282 · Cited by 721 · see citing works

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice

Matoba, T., Shimokawa, H., Nakashima, M., Hirakawa, Y., Mukai, Y., Hirano, K., Kanaide, H., & Takeshita, A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10506 · Cited by 721 · see citing works

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

Xia, Y., Dawson, V. L., Dawson, T. M., Snyder, S. H., & Zweier, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6770 · Cited by 718 · see citing works

Analysis of reduced forms of biopterin in biological tissues and fluids

Fukushima, T., & Nixon, J. C. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90336-x · Cited by 712 · see citing works

NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease

Cooke, J. P., & Dzau, V. J. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.489 · Cited by 710 · see citing works

Superoxide Generation from Endothelial Nitric-oxide Synthase

Xia, Y., Tsai, A.-L., Berka, V., & Zweier, J. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25804 · Cited by 705 · see citing works

Role of NADH/NADPH Oxidase–Derived H 2 O 2 in Angiotensin II–Induced Vascular Hypertrophy

Zafari, A. M., Ushio‐Fukai, M., Akers, M., Yin, Q., Shah, A. A., Harrison, D. G., Taylor, W. R., & Griendling, K. K. (1998) · Hypertension · doi:10.1161/01.hyp.32.3.488 · Cited by 610 · see citing works

STRUCTURE-FUNCTION ASPECTS IN THE NITRIC OXIDE SYNTHASES

Stuehr, D. J. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.339 · Cited by 547 · see citing works

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

Heinzel, B., John, M., Klatt, P., Böhme, E., & Mayer, B. (1992) · Biochemical Journal · doi:10.1042/bj2810627 · Cited by 530 · see citing works

Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

Milstien, S., & Katušić, Z. S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1422 · Cited by 488 · see citing works

The p47phox mouse knock-out model of chronic granulomatous disease.

Jackson, S. H., Gallin, J. I., & Holland, S. M. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.751 · Cited by 484 · see citing works

Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

Heitzer, T. A., Brockhoff, C. J., Mayer, B., Warnholtz, A., Mollnau, H., Henne, S., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.86.2.e36 · Cited by 449 · see citing works

l-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin

Heller, R., Unbehaun, A., Schellenberg, B., Mayer, B., Werner‐Felmayer, G., & Werner, E. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004392200 · Cited by 421 · see citing works

Oxygen Reduction by Nitric-oxide Synthases

Stuehr, D. J., Pou, S., & Rosen, G. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100011200 · Cited by 400 · see citing works

Treatment of hypertension with ascorbic acid

Duffy, S., Gokce, N., HOLBROOK, M. M., Huang, A., Frei, B. B., Keaney, J. F., & Vita, J. A. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04410-4 · Cited by 333 · see citing works

Stimulation of a Vascular Smooth Muscle Cell NAD(P)H Oxidase by Thrombin

Patterson, C., Ruef, J., Madamanchi, N. R., Barry-Lane, P., Hu, Z., Horaist, C., Ballinger, C. A., Brasier, A. R., Bode, C., & Runge, M. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19814 · Cited by 330 · see citing works

Essential Role of the NADPH Oxidase Subunit p47 phox in Endothelial Cell Superoxide Production in Response to Phorbol Ester and Tumor Necrosis Factor-α

Li, J., Mullen, A. M., Yun, S., Wientjes, F. B., Brouns, G. Y., Thrasher, A. J., & Shah, A. M. (2002) · Circulation Research · doi:10.1161/hh0202.103615 · Cited by 312 · see citing works

Fluid Flow Inhibits Endothelial Adhesiveness

Tsao, P. S., Buitrago, R., Chan, J. R., & Cooke, J. P. (1996) · Circulation · doi:10.1161/01.cir.94.7.1682 · Cited by 303 · see citing works

Tetrahydrobiopterin and Dysfunction of Endothelial Nitric Oxide Synthase in Coronary Arteries

Cosentino, F., & Katušić, Z. S. (1995) · Circulation · doi:10.1161/01.cir.91.1.139 · Cited by 294 · see citing works

Tetrahydrobiopterin Regulates Superoxide and Nitric Oxide Generation by Recombinant Endothelial Nitric Oxide Synthase

Wever, R. M. F., van Dam, T., van Rijn, H. J. M., de Groot, F. G., & Rabelink, T. J. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7069 · Cited by 281 · see citing works

Vascular Superoxide Production and Vasomotor Function in Hypertension Induced by Deoxycorticosterone Acetate–Salt

Somers, M. J., Mavromatis, K., Galis, Z. S., & Harrison, D. G. (2000) · Circulation · doi:10.1161/01.cir.101.14.1722 · Cited by 280 · see citing works

Platelet-Derived Growth Factor–Stimulated Superoxide Anion Production Modulates Activation of Transcription Factor NF-κB and Expression of Monocyte Chemoattractant Protein 1 in Human Aortic Smooth Muscle Cells

Marumo, T., Schini‐Kerth, V. B., Fißlthaler, B., & Busse, R. (1997) · Circulation · doi:10.1161/01.cir.96.7.2361 · Cited by 252 · see citing works

Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91- phox and p22- phox in Endothelial Cells

Bayraktutan, U., BLAYNEY, L. M., & Shah, A. M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.8.1903 · Cited by 239 · see citing works

Neuronal Nitric Oxide Synthase Is Expressed in Rat Vascular Smooth Muscle Cells

Boulanger, C. M., Heymes, C., Bénessiano, J., Geske, R. S., Levy, B. I., & Vanhoutte, P. M. (1998) · Circulation Research · doi:10.1161/01.res.83.12.1271 · Cited by 217 · see citing works

Nitric Oxide Modulates Expression of Cell Cycle Regulatory Proteins

Tanner, F. C., Meier, P., Greutert, H., Champion, C., Nabel, E. G., & Lüscher, T. F. (2000) · Circulation · doi:10.1161/01.cir.101.16.1982 · Cited by 213 · see citing works

Pulsatile Stretch Stimulates Superoxide Production and Activates Nuclear Factor-κB in Human Coronary Smooth Muscle

Hishikawa, K., Oemar, B. S., Yang, Z., & Lüscher, T. F. (1997) · Circulation Research · doi:10.1161/01.res.81.5.797 · Cited by 200 · see citing works

Redox control of vascular smooth muscle proliferation

Griendling, K. K., & Ushio‐Fukai, M. (1998) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(98)90019-1 · Cited by 199 · see citing works

Mechanism of Superoxide Generation by Neuronal Nitric-oxide Synthase

Pou, S., Keaton, L., Surichamorn, W., & Rosen, G. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9573 · Cited by 190 · see citing works

Pulsatile Stretch Stimulates Superoxide Production in Human Aortic Endothelial Cells

Hishikawa, K., & Lüscher, T. F. (1997) · Circulation · doi:10.1161/01.cir.96.10.3610 · Cited by 182 · see citing works

Tetrahydrobiopterin and endothelial nitric oxide synthase activity

Cosentino, F. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00134-0 · Cited by 173 · see citing works

Cyclic strain induces an oxidative stress in endothelial cells

Howard, A. B., Alexander, R. W., Nerem, R. M., Griendling, K. K., & Taylor, W. R. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.272.2.c421 · Cited by 171 · see citing works

Reactive Oxygen Species Mediate Endothelium-Dependent Relaxations in Tetrahydrobiopterin-Deficient Mice

Cosentino, F., Barker, J. E., Brand, M. P., Heales, S., Werner, E. R., Tippins, J. R., West, N. E. J., Channon, K. M., Volpe, M., & Lüscher, T. F. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.496 · Cited by 171 · see citing works

Dual Role of Reactive Oxygen Species in Vascular Growth

Griendling, K. K., & Harrison, D. G. (1999) · Circulation Research · doi:10.1161/01.res.85.6.562 · Cited by 149 · see citing works

Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: contributions of NOS isoforms to blood pressure and heart rate control

Kojda, G. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00315-0 · Cited by 132 · see citing works

Pressure and Angiotensin II Synergistically Induce Aortic Fibronectin Expression in Organ Culture Model of Rabbit Aorta

Bardy, N., Merval, R., Benessiano, J., et al. (1996) · Circulation Research · doi:10.1161/01.res.79.1.70 · Cited by 115 · see citing works

Increased Superoxide Production during Fatigue in the Perfused Rat Diaphragm

Kolbeck, R. C., She, Z.-W., Callahan, L. A., & NOSEK, A. T. M. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.1.9610041 · Cited by 111 · see citing works

Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate

Patel, K. B., Stratford, M. R. L., Wardman, P., & Everett, S. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00777-8 · Cited by 95 · see citing works

Vascular angiotensin II receptors in renal and DOCA-salt hypertensive rats.

Schiffrin, E. L., Thomé, F. S., & Genest, J. J. (1983) · Hypertension · doi:10.1161/01.hyp.5.6_pt_3.v16 · Cited by 49 · see citing works

Development of hypertension in animals with reduced total peripheral resistance.

Huang, M. H., Hester, R. L., Coleman, T. G., Smith, M. J., & Guyton, A. C. (1992) · Hypertension · doi:10.1161/01.hyp.20.6.828 · Cited by 32 · see citing works

Evidence for a NADH/NADPH Oxidase in Human Umbilical Vein Endothelial Cells Using Electron Spin Resonance

Somers, M. J., Burchfield, J. S., & Harrison, D. G. (2000) · Antioxidants and Redox Signaling · doi:10.1089/ars.2000.2.4-779 · Cited by 32 · see citing works

Inhibition of Luminol-Enhanced Chemiluminescence by Reduced Pterins

Shen, R. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1140 · Cited by 27 · see citing works

Fluoroscopic Diagnosis of Native Valve Endocarditis

Raman, S. V., Bacon, J. P., Magorien, R. D., & Eaton, G. M. (2001) · Circulation · doi:10.1161/hc4001.096828 · Cited by 23 · see citing works

Regulation of Aortic Atrial Natriuretic Factor and Angiotensinogen in Experimental Hypertension

Ogawa, T., Linz, W., Schölkens, B. A., et al. (1998) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199812000-00019 · Cited by 6 · see citing works

Reactive Oxygen Species in Inflammation and Tissue Injury

Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897 · see citing works

Nitric oxide synthases: regulation and function

Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works

Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace

Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · see citing works

Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness

Zieman, S. J., Melenovsky, V., & Kass, D. A. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000160548.78317.29 · Cited by 1,854 · see citing works

Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction

Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736 · see citing works

Oxidative Stress and Vascular Disease

Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000150649.39934.13 · Cited by 1,618 · see citing works

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

Bulua, A. C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K.-Y., Sack, M. N., Kastner, D. L., & Siegel, R. M. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102049 · Cited by 860 · see citing works

Endothelial Function: A Critical Determinant in Atherosclerosis?

Landmesser, U., Hornig, B., & Drexler, H. (2004) · Circulation · doi:10.1161/01.cir.0000129501.88485.1f · Cited by 851 · see citing works

Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)

Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818 · see citing works

Cross talk between mitochondria and NADPH oxidases

Dikalov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.033 · Cited by 783 · see citing works

Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology

Li, J.-M., & Shah, A. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00124.2004 · Cited by 773 · see citing works

NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology

Vermot, A., Petit-Härtlein, I., Smith, S. M. E., & Fieschi, F. (2021) · Antioxidants · doi:10.3390/antiox10060890 · Cited by 766 · see citing works

Aging and vascular endothelial function in humans

Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725 · see citing works

Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

Kuzkaya, N., Weissmann, N., Harrison, D. G., & Dikalov, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302227200 · Cited by 692 · see citing works

The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

Cai, H., Griendling, K. K., & Harrison, D. G. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00233-5 · Cited by 687 · see citing works

Methods for detection of reactive metabolites of oxygen and nitrogen: In vitro and in vivo considerations

Tarpey, M. M., Wink, D. A., & Grisham, M. B. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00361.2003 · Cited by 673 · see citing works

NADPH Oxidases in Cardiovascular Health and Disease

Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.691 · Cited by 630 · see citing works

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

Schröder, K., Zhang, M., Benkhoff, S., Mieth, A., Pliquett, R., Kosowski, J., Kruse, C., Luedike, P., Michaelis, U. R., Weissmann, N., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.267054 · Cited by 622 · see citing works

Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies

Förstermann, U. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1211 · Cited by 576 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Measurement of Reactive Oxygen Species in Cardiovascular Studies

Dikalov, S., Griendling, K. K., & Harrison, D. G. (2007) · Hypertension · doi:10.1161/01.hyp.0000258594.87211.6b · Cited by 532 · see citing works

New developments and novel therapeutic perspectives for vitamin C

Li, Y., & Schellhorn, H. E. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.10.2171 · Cited by 508 · see citing works

Tetrahydrobiopterin: biochemistry and pathophysiology

Werner, E. R., Blau, N., & Thöny, B. (2011) · Biochemical Journal · doi:10.1042/bj20110293 · Cited by 493 · see citing works

eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues

Balligand, J.-L., Feron, O., & Dessy, C. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2007 · Cited by 477 · see citing works

The role of oxidative stress in the pathophysiology of hypertension

Rodrigo, R., González, J., & Paoletto, F. (2011) · Hypertension Research · doi:10.1038/hr.2010.264 · Cited by 436 · see citing works

Molecular mechanisms underlying the activation of eNOS

Fleming, I. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0767-7 · Cited by 437 · see citing works

Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension

Schulz, E., Jansen, T., Wenzel, P., Daiber, A., & Münzel, T. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1989 · Cited by 430 · see citing works

Mitochondrial dysfunction in cardiovascular disease

Ballinger, S. W. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.014 · Cited by 405 · see citing works

Pulmonary Arterial Hypertension: The Clinical Syndrome

Lai, Y.-C., Potoka, K. C., Champion, H. C., Mora, A. L., & Gladwin, M. T. (2014) · Circulation Research · doi:10.1161/circresaha.115.301146 · Cited by 402 · see citing works

Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy

Sorrentino, S. A., Besler, C., Rohrer, L., Meyer, M., Heinrich, K., Bahlmann, F. H., Mueller, M., Horváth, T., Doerries, C., Heinemann, M., et al. (2010) · Circulation · doi:10.1161/circulationaha.108.836346 · Cited by 402 · see citing works

Redox Control of Endothelial Function and Dysfunction: Molecular Mechanisms and Therapeutic Opportunities

Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383 · see citing works

5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide Production in Human Vessels: Effects on Vascular Tetrahydrobiopterin Availability and Endothelial Nitric Oxide Synthase Coupling

Antoniades, C., Shirodaria, C., Warrick, N., Cai, S., de Bono, J., Lee, J., Leeson, P., Neubauer, S., Ratnatunga, C., Pillai, R., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.612325 · Cited by 365 · see citing works

Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans

Miller, J. D., Chu, Y., Brooks, R. M., Richenbacher, W. E., Peña-Silva, R., & Heistad, D. D. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.043 · Cited by 357 · see citing works

Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358 · see citing works

Physical Inactivity Increases Oxidative Stress, Endothelial Dysfunction, and Atherosclerosis

Laufs, U., Wassmann, S., Czech, T., Münzel, T., Eisenhauer, M., Böhm, M., & Nickenig, G. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000158311.24443.af · Cited by 327 · see citing works

Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome

Roberts, C. K., Barnard, R. J., Sindhu, R. K., Jurczak, M., Ehdaie, A., & Vaziri, N. D. (2006) · Metabolism · doi:10.1016/j.metabol.2006.02.022 · Cited by 322 · see citing works

Oxidative stress in vascular disease and its pharmacological prevention

Li, H., Horke, S., & Förstermann, U. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.03.007 · Cited by 321 · see citing works

Endothelial NADPH oxidases: which NOX to target in vascular disease?

Drummond, G. R., & Sobey, C. G. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.06.012 · Cited by 315 · see citing works

Biochemical basis and metabolic interplay of redox regulation

Zhang, L., Wang, X., Cueto, R., Effi, C., Zhang, Y., Tan, H., Qin, X., Ji, Y., Yang, X., & Wang, H. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101284 · Cited by 308 · see citing works

Regulation of obesity and insulin resistance by nitric oxide

Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works

Endothelial Arginase II: A Novel Target for the Treatment of Atherosclerosis

Ryoo, S., Gupta, G., Benjo, A., Lim, H. K., Camara, A., Sikka, G., Lim, H. K., Sohi, J., Santhanam, L., Soucy, K., et al. (2008) · Circulation Research · doi:10.1161/circresaha.107.169573 · Cited by 236 · see citing works

Tetrahydrobiopterin in Cardiovascular Health and Disease

Bendall, J. K., Douglas, G., McNeill, E., Channon, K. M., & Crabtree, M. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5566 · Cited by 231 · see citing works

Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling

Antoniades, C., Bakogiannis, C., Leeson, P., Guzik, T. J., Zhang, M.-H., Tousoulis, D., Antonopoulos, A. S., Demosthenous, M., Marinou, K., Hale, A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.985150 · Cited by 219 · see citing works

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging: Sodium nitrite and vascular dysfunction with aging

Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00679.x · Cited by 218 · see citing works

Possible role of oxidative stress in the pathogenesis of hypertension

Ceriello, A. (2008) · Diabetes Care · doi:10.2337/dc08-s245 · Cited by 215 · see citing works

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS

Crabtree, M. J., Smith, C. L., Lam, G., Goligorsky, M. S., & Gross, S. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00823.2007 · Cited by 213 · see citing works

Critical Role of the NAD(P)H Oxidase Subunit p47 ^<i>phox</i> for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction

Doerries, C., Grote, K., Hilfiker-Kleiner, D., Luchtefeld, M., Schaefer, A., Holland, S. M., Sorrentino, S., Manes, C., Schieffer, B., Drexler, H., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000261657.76299.ff · Cited by 206 · see citing works

Role of Extracellular Superoxide Dismutase in Hypertension

Gongora, M. C., Qin, Z., Laude, K., Kim, H. W., McCann, L., Folz, J. R., Dikalov, S., Fukai, T., & Harrison, D. G. (2006) · Hypertension · doi:10.1161/01.hyp.0000235682.47673.ab · Cited by 204 · see citing works

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

Crabtree, M. J., Tatham, A. L., Al-Wakeel, Y., Warrick, N., Hale, A. B., Cai, S., Channon, K. M., & Alp, N. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805403200 · Cited by 200 · see citing works

Increased Endothelial Tetrahydrobiopterin Synthesis by Targeted Transgenic GTP-Cyclohydrolase I Overexpression Reduces Endothelial Dysfunction and Atherosclerosis in ApoE-Knockout Mice

Alp, N. J., McAteer, M. A., Khoo, J., Choudhury, R. P., & Channon, K. M. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000115637.48689.77 · Cited by 194 · see citing works

Myocardial ischemia results in tetrahydrobiopterin (BH ₄ ) oxidation with impaired endothelial function ameliorated by BH ₄

Dumitrescu, C., Biondi, R., Xia, Y., Cardounel, A. J., Druhan, L. J., Ambrosio, G., & Zweier, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702986104 · Cited by 192 · see citing works

New insights on oxidative stress in the artery wall

STOCKER, R., & KEANEY, J. F. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01370.x · Cited by 188 · see citing works

Tumor Necrosis Factor-α Inhibits Endothelial Nitric-oxide Synthase Gene Promoter Activity in Bovine Aortic Endothelial Cells

Anderson, H. D. I., Rahmutula, D., & Gardner, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309552200 · Cited by 186 · see citing works

Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition

Wind, S., Beuerlein, K., Armitage, M. E., Taye, A., Kumar, A. H. S., Janowitz, D., Neff, C., Shah, A. M., Wingler, K., & Schmidt, H. H. H. W. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.149187 · Cited by 181 · see citing works

Upregulation of nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via enos uncoupling

Dikalova, A. E., Góngora, M. C., Harrison, D. G., Lambeth, J. D., Dikalov, S., & Griendling, K. K. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00242.2010 · Cited by 179 · see citing works

Tyrosine metabolism during interferon-alpha administration: Association with fatigue and CSF dopamine concentrations

Felger, J. C., Li, L., Marvar, P. J., Woolwine, B. J., Harrison, D. G., Raison, C. L., & Miller, A. H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.010 · Cited by 176 · see citing works

Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes

Funk, S. D., Yurdagul, A., & Orr, A. W. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/569654 · Cited by 176 · see citing works

Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases

Omar, S. A., Webb, A. J., Lundberg, J. O., & Weitzberg, E. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12441 · Cited by 175 · see citing works

ROS-induced ROS release in vascular biology: redox-redox signaling

Zinkevich, N. S., & Gutterman, D. D. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01271.2010 · Cited by 163 · see citing works

Endothelial Nox2 Overexpression Potentiates Vascular Oxidative Stress and Hemodynamic Response to Angiotensin II: Studies in Endothelial-Targeted Nox2 Transgenic Mice

Bendall, J. K., Rinze, R., Adlam, D., Tatham, A. L., de Bono, J., & Channon, K. M. (2007) · Circulation Research · doi:10.1161/01.res.0000263381.83835.7b · Cited by 157 · see citing works

Altered Plasma Versus Vascular Biopterins in Human Atherosclerosis Reveal Relationships Between Endothelial Nitric Oxide Synthase Coupling, Endothelial Function, and Inflammation

Antoniades, C., Shirodaria, C., Crabtree, M., Rinze, R., Alp, N., Cunnington, C., Diesch, J., Tousoulis, D., Stefanadis, C., Leeson, P., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.704155 · Cited by 153 · see citing works

Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia

Cosentino, F., Hürlimann, D., Delli Gatti, C., Chenevard, R., Blau, N., Alp, N. J., Channon, K. M., Eto, M., Lerch, P., Enseleit, F., et al. (2008) · Heart · doi:10.1136/hrt.2007.122184 · Cited by 143 · see citing works

NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice

Langbein, H., Brunssen, C., Hofmann, A., Cimalla, P., Brux, M., Bornstein, S. R., Deussen, A., Koch, E., & Morawietz, H. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv564 · Cited by 133 · see citing works

The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes

Youn, J. Y., Gao, L., & Cai, H. (2012) · Diabetologia · doi:10.1007/s00125-012-2557-6 · Cited by 128 · see citing works

Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction

Bhayadia, R., Schmidt, B. M. W., Melk, A., & Hömme, M. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv008 · Cited by 126 · see citing works

Hyperglycaemic Impairment of PAR2-Mediated Vasodilation: Prevention by Inhibition of Aortic Endothelial Sodium-Glucose-Co-Transporter-2 and Minimizing Oxidative Stress

El-Daly, M., Pulakazhi Venu, V. K., Saifeddine, M., Mihara, K., Kang, S., Fedak, P. W. M., Alston, L. A., Hirota, S. A., Ding, H., Triggle, C. R., et al. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.06.006 · Cited by 117 · see citing works

Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats

Viel, E. C., Benkirane, K., Javeshghani, D., Touyz, R. M., & Schiffrin, E. L. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00304.2008 · Cited by 116 · see citing works

Nox1, 2, 4, 5: Counting out oxidative stress

Wingler, K., Hermans, J., Schiffers, P., Moens, A., Paul, M., & Schmidt, H. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01249.x · Cited by 113 · see citing works

The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies

Hobbs, D. A., George, T. W., & Lovegrove, J. A. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000188 · Cited by 114 · see citing works

Endothelial Dysfunction in the Microcirculation of Patients with Obstructive Sleep Apnea

Patt, B. T., Jarjoura, D., Haddad, D. N., Sen, C. K., Roy, S., Flavahan, N. A., & Khayat, R. N. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201002-0162oc · Cited by 101 · see citing works

Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1–Dependent Uncoupling of Endothelial Nitric Oxide Synthase

Villalba, N., Sackheim, A. M., Nunez, I. A., Hill-Eubanks, D. C., Nelson, M. T., Wellman, G. C., & Freeman, K. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2015.4340 · Cited by 99 · see citing works

Endothelial nitric oxide synthase: A potential therapeutic target for cerebrovascular diseases

Zhu, J., Song, W., Li, L., & Fan, X. (2016) · Molecular Brain · doi:10.1186/s13041-016-0211-9 · Cited by 96 · see citing works

NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis

Santillo, M., Colantuoni, A., Mondola, P., Guida, B., & Damiano, S. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00194 · Cited by 95 · see citing works

Triggering Mitochondrial Radical Release: A New Function for NADPH Oxidases

Brandes, R. P. (2005) · Hypertension · doi:10.1161/01.hyp.0000165019.32059.b2 · Cited by 79 · see citing works

Inorganic nitrite supplementation for healthy arterial aging

Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works

Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice

Santhanam, A. V. R., d’Uscio, L. V., Smith, L. A., & Katusic, Z. S. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07872.x · Cited by 64 · see citing works

Cell-Autonomous Role of Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation

Chuaiphichai, S., McNeill, E., Douglas, G., Crabtree, M. J., Bendall, J. K., Hale, A. B., Alp, N. J., & Channon, K. M. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03089 · Cited by 63 · see citing works

Endothelial function and the regulation of muscle protein anabolism in older adults

Timmerman, K. L., & Volpi, E. (2013) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.03.013 · Cited by 53 · see citing works

Tetrahydrobiopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase-dependent manner in diabetic mice

Abudukadier, A., Fujita, Y., Obara, A., Ohashi, A., Fukushima, T., Sato, Y., Ogura, M., Nakamura, Y., Fujimoto, S., Hosokawa, M., et al. (2013) · Diabetes · doi:10.2337/db12-1242 · Cited by 52 · see citing works

Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation

Chen, W., Li, L., Brod, T., Saeed, O., Thabet, S., Jansen, T., Dikalov, S., Weyand, C., Goronzy, J., & Harrison, D. G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.191023 · Cited by 36 · see citing works

Role of SIRT3 in Angiotensin II-induced human umbilical vein endothelial cells dysfunction

Liu, H., Chen, T., Li, N., Wang, S., & Bu, P. (2015) · BMC Cardiovascular Disorders · doi:10.1186/s12872-015-0075-4 · Cited by 36 · see citing works

Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats

Shirakura, T., Nomura, J., Matsui, C., Kobayashi, T., Tamura, M., & Masuzaki, H. (2016) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-016-1239-1 · Cited by 36 · see citing works

Asymmetric Dimethylarginine Is a Well Established Mediating Risk Factor for Cardiovascular Morbidity and Mortality—Should Patients with Elevated Levels Be Supplemented with Citrulline?

McCarty, M. (2016) · Healthcare · doi:10.3390/healthcare4030040 · Cited by 25 · see citing works

Understanding the causes and implications of endothelial metabolic variation in cardiovascular disease through genome-scale metabolic modeling

McGarrity, S., Halldórsson, H., Palsson, S., Johansson, P. I., & Rolfsson, Ó. (2016) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2016.00010 · Cited by 12 · see citing works

Nitric oxide formation in acutely rejecting cardiac allografts correlates with GTP cyclohydrolase I activity

Pieper, G. M., Nilakantan, V., Halligan, N. L. N., Khanna, A. K., Hilton, G., & Vasquez-Vivar, J. M. (2005) · Biochemical Journal · doi:10.1042/bj20050575 · Cited by 8 · see citing works

Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism

Kuzuya, H., Sakamoto, H., & Fujita, K. (1998) · Pteridines · doi:10.1515/pteridines.1998.9.1.39

Tetrahydrobiopterin biosynthesis defects examined in cytokine‐stimulated fibroblasts

Milstien, S., Kaufman, S., & Sakai, N. (1993) · Journal of Inherited Metabolic Disease · doi:10.1007/bf00711513 · Cited by 16 · see citing works

GTP Cyclohydrolase I Is Coinduced in Hepatocytes Stimulated to Produce Nitric Oxide

Geller, D. A., Silvio, M. D., Billiar, T. R., & Hatakeyama, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3537 · Cited by 23 · see citing works

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation

Cai, S. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00460-1 · Cited by 105 · see citing works