Cited by 342Obstructive Sleep Apnea ResearchNeuroscience of respiration and sleepSleep and related disorders

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers.

Open access

Louis, Mariam, Punjabi, Naresh M.·2009·Journal of Applied Physiology

DOI 10.1152/japplphysiol.91523.2008PMC PMC2681331

Open this paper in CoChat — free account

Abstract

Accumulating evidence suggests that obstructive sleep apnea is associated with alterations in glucose metabolism. Although the pathophysiology of metabolic dysfunction in obstructive sleep apnea is not well understood, studies of murine models indicate that intermittent hypoxemia has an important contribution. However, corroborating data on the metabolic effects of intermittent hypoxia on glucose metabolism in humans are not available. Thus the primary aim of this study was to characterize the acute effects of intermittent hypoxia on glucose metabolism. Thirteen healthy volunteers were subjected to 5 h of intermittent hypoxia or normoxia during wakefulness in a randomized order on two separate days. The intravenous glucose tolerance test (IVGTT) was used to assess insulin-dependent and insulin-independent measures of glucose disposal. The IVGTT data were analyzed using the minimal model to determine insulin sensitivity (S I ) and glucose effectiveness (S G ). Drops in oxyhemoglobin saturation were induced during wakefulness at an average rate of 24.3 events/h. Compared with the normoxia condition, intermittent hypoxia was associated with a decrease in S I [4.1 vs. 3.4 (mU/l) −1 ·min −1 ; P = 0.0179] and S G (1.9 vs. 1.3 min −1 ×10 −2 , P = 0.0065). Despite worsening insulin sensitivity with intermittent hypoxia, pancreatic insulin secretion was comparable between the two conditions. Heart rate variability analysis showed the intermittent hypoxia was associated with a shift in sympathovagal balance toward an increase in sympathetic nervous system activity. The average R-R interval on the electrocardiogram was 919.0 ms during the normoxia condition and 874.4 ms during the intermittent hypoxia condition ( P < 0.04). Serum cortisol levels after intermittent hypoxia and normoxia were similar. Hypoxic stress in obstructive sleep apnea may increase the predisposition for metabolic dysfunction by impairing insulin sensitivity, glucose effectiveness, and insulin secretion.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.91523.2008

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289
Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
King, H. O. M., Aubert, R. E., & Herman, W. H. (1998) · Diabetes Care · doi:10.2337/diacare.21.9.1414 · Cited by 6,294
Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.
(1996) · PubMed · Cited by 5,666
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
Type 2 diabetes: principles of pathogenesis and therapy
Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166
Quantitative estimation of insulin sensitivity.
Bergman, R. N., Ider, Y. Z., Bowden, C. R., & Cobelli, C. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.236.6.e667 · Cited by 1,874 · cited 2×
“The resulting glucose and insulin values during the intermittent hypoxia and normoxia conditions were subjected to the minimal model analysis (5, 7, 9) for determination of insulin sensitivity (SI), glucose effectiveness (SG), and glucose effectiveness at zero insulin (GEZI).”
Method
Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study
Punjabi, N. M. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh261 · Cited by 1,107
Self-citation

Flagged first, then by citations

Show all 40 references

Sorted by citations

Items 101–200 of 341

Metabolic Disorders Associated with Obstructive Sleep Apnea in Adults
(2011) · Advances in cardiology · doi:10.1159/000325106 · Cited by 41
Nocturnal saturation and glucose tolerance in children with cystic fibrosis
Suratwala, D., Chan, J. S. H., Kelly, A., Meltzer, L. J., Gallagher, P. R., Traylor, J. T., Rubenstein, R. C., & Marcus, C. L. (2011) · Thorax · doi:10.1136/thx.2010.142141 · Cited by 41
The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition
Mekjavić, I. B., Amon, M., Kölegård, R., Kounalakis, S. N., Simpson, L., Eiken, O., Keramidas, M. E., & Macdonald, I. A. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00202 · Cited by 41
MECHANISMS OF ENDOCRINOLOGY: Mechanisms of disease: the endocrinology of obstructive sleep apnoea
Lavrentaki, A., Ali, A., Cooper, B. G., & Tahrani, A. A. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0411 · Cited by 48
Sleep Apnea–Hypopnea Syndrome and Type 2 Diabetes. A Reciprocal Relationship?
Martínez-Cerón, E., Mateos, R. C., & Rio, F. G. (2015) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2014.12.007 · Cited by 41
Post-metabolic response to passive normobaric hypoxic exposure in sedendary overweight males: a pilot study
Workman, C., & Basset, F. A. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-103 · Cited by 40
Thermoneutrality modifies the impact of hypoxia on lipid metabolism
Jun, J. C., Shin, M., Yao, Q., Devera, R., Bevans‐Fonti, S., & Polotsky, V. Y. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00515.2012 · Cited by 39
Síndrome de apneas-hipopneas del sueño y diabetes tipo 2. ¿Una relación de ida y vuelta?
Martínez-Cerón, E., Mateos, R. C., & Rio, F. G. (2014) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2014.06.017 · Cited by 41
Obstructive Sleep Apnea and Cardiovascular Diseases: Sad Realities and Untold Truths regarding Care of Patients in 2022
Gunta, S. P., Jakulla, R. S., Ubaid, A., Mohamed, K., Bhat, A., López‐Candales, A., & Norgard, N. B. (2022) · Cardiovascular Therapeutics · doi:10.1155/2022/6006127 · Cited by 45
Inhibition of Lipolysis Ameliorates Diabetic Phenotype in a Mouse Model of Obstructive Sleep Apnea
Weiszenstein, M., Shimoda, L. A., Koc, M., Šeda, O., & Polak, J. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0315oc · Cited by 38
Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia
Lee, E. J., Alonso, L. C., Stefanovski, D., Strollo, H., Romano, L. C., Zou, B., Singamsetty, S., Yester, K. A., McGaffin, K. R., García-Ocaña, A., et al. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2452-3 · Cited by 38
Association between obstructive sleep apnea severity and glucose control in patients with untreated versus treated diabetes
Priou, P., Vaillant, M. L., Meslier, N., Chollet, S., Pigeanne, T., Masson, P., Bizieux‐Thaminy, A., Humeau, M. P., Goupil, F., Ducluzeau, P., et al. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12278 · Cited by 38
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
Fernandes, J. L., Martins, F. O., Olea, E., Prieto‐Lloret, J., Braga, P. C., Sacramento, J. F., Sequeira, C. O., Negrinho, A. P., Pereira, S. A., Alves, M. G., et al. (2023) · Antioxidants · doi:10.3390/antiox12111910 · Cited by 38
Sleep apnoea, insulin resistance and diabetes: the first step is in the fat
Almendros, I., & García-Río, F. (2017) · European Respiratory Journal · doi:10.1183/13993003.00179-2017 · Cited by 34
Hypoxia alters testicular functions of marine medaka through microRNAs regulation
Tse, A. C.-K., Li, J., Wang, S. Y., Chan, T., Lai, K. P., & Wu, R. S. S. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.10.007 · Cited by 36
Obstructive sleep apnea in gestational diabetes: a pilot study of the role of the hypothalamic-pituitary-adrenal Axis
Bublitz, M. H., Monteiro, J. F., Caraganis, A., Martin, S., Parker, J., Larson, L., Miller, M. A., & Bourjeily, G. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6888 · Cited by 34
Intermittent Hypoxia in Childhood: The Harmful Consequences Versus Potential Benefits of Therapeutic Uses
Serebrovskaya, T. V., & Xi, L. (2015) · Frontiers in Pediatrics · doi:10.3389/fped.2015.00044 · Cited by 34
Disorders of Glucose Metabolism in Sleep-disordered Breathing
Lui, M. M., & Ip, M. (2010) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2010.02.001 · Cited by 31
Glucose, insulin, and insulin resistance in normal-weight, overweight and obese children with obstructive sleep apnea
Shamsuzzaman, A., Szczesniak, R. D., Fenchel, M. C., & Amin, R. S. (2013) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2013.11.006 · Cited by 34
Obstructive sleep apnea is associated with liver disease: a population-based cohort study
Chou, T., Liang, W.-M., Wang, C., Wu, T.-N., & Hang, L. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.02.542 · Cited by 36
The Effect of Aging and Severity of Sleep Apnea on Heart Rate Variability Indices in Obstructive Sleep Apnea Syndrome
Song, M.-K., Ha, J. H., Ryu, S., Yu, J., & Park, D. (2012) · Psychiatry Investigation · doi:10.4306/pi.2012.9.1.65 · Cited by 34
Obstructive sleep apnoea, insulin resistance and adipocytokines
Lam, D. C.-L., Lam, K. S. L., & Ip, M. (2014) · Clinical Endocrinology · doi:10.1111/cen.12597 · Cited by 33
Relationship between Sleep Disorders and the Risk for Developing Type 2 Diabetes Mellitus
Ioja, S., Weir, I. D., & Rennert, N. J. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.07.2573 · Cited by 32
Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link
Brzecka, A., Madetko‐Alster, N., Nikolenko, V. N., Ashraf, G. M., Ejma, M., Leszek, J., Daroszewski, C., Sarul, K., Михалева, Л. М., Somasundaram, S. G., et al. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200309101750 · Cited by 35
Current and future strategies for diagnostic and management of obstructive sleep apnea
Khurana, S., Soda, N., Shiddiky, M. J. A., Nayak, R., & Bose, S. K. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.2002686 · Cited by 32
The role of sleep duration and sleep disordered breathing in gestational diabetes mellitus
Gooley, J. J., Mohapatra, L., & Twan, D. C. K. (2017) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2017.11.001 · Cited by 35
Sleep disordered breathing in REM sleep reverses the downward trend in glucose concentration
Białasiewicz, P., Czupryniak, L., Pawlowski, M., & Nowak, D. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2010.04.017 · Cited by 32
The effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia
Shin, M., Han, W., Bevans‐Fonti, S., Jun, J. C., Punjabi, N. M., & Polotsky, V. Y. (2014) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2014.08.018 · Cited by 32
Self-citation
Obstructive sleep apnea syndrome in adults with down syndrome: Causes and consequences. Is it a "chicken and egg" question?
Dumortier, L., & Bricout, V. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.018 · Cited by 33
Advances in Exercise, Physical Activity, and Diabetes Mellitus
Pasieka, A. M., Nikoletos, N., & Riddell, M. C. (2016) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2016.2508 · Cited by 30
Glucose homoeostasis in rats exposed to acute intermittent hypoxia
Rafacho, A., Gonçalves-Neto, L. M., Ferreira, F. B. D., Protzek, A. O. P., Boschero, A. C., Nunes, E. A., & Zoccal, D. B. (2013) · Acta Physiologica · doi:10.1111/apha.12118 · Cited by 31
Glucoregulatory Consequences and Cardiorespiratory Parameters in Rats Exposed to Chronic–Intermittent Hypoxia: Effects of the Duration of Exposure and Losartan
Fenik, V. B., Singletary, T., Branconi, J. L., Davies, R. O., & Kubin, L. K. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00051 · Cited by 29
Effect of Continuous Positive Airway Pressure Therapy on Glycemic Excursions and Insulin Sensitivity in Patients with Obstructive Sleep Apnea-hypopnea Syndrome and Type 2 Diabetes
Guo, L., Zhao, X., Pan, Q., Sun, X. F., Li, H., Wang, X., Zhang, L., & Wang, Y. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.163382 · Cited by 30
A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle
Mackenzie, R., & Watt, P. (2016) · Journal of Diabetes Research · doi:10.1155/2016/6934937 · Cited by 32
Analysis of prevalence and prognosis of type 2 diabetes mellitus in patients with acute exacerbation of COPD
Lin, L., Shi, J., Kang, J., & Wang, Q. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-01371-9 · Cited by 28
Novel insights into metabolic sequelae of obstructive sleep apnoea: A link between hypoxic stress and chronic diabetes complications
Pallayová, M., Banerjee, D., & Taheri, S. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.01.007 · Cited by 28
The relationship between sleep and glucagon‐like peptide 1 in patients with abnormal glucose tolerance
Reutrakul, S., Sumritsopak, R., Saetung, S., Chanprasertyothin, S., & Anothaisintawee, T. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12552 · Cited by 28
Sympathetic neural recruitment strategies following acute intermittent hypoxia in humans
Ott, E. P., Jacob, D. W., Baker, S. E., Holbein, W. W., Scruggs, Z. M., Shoemaker, J. K., & Limberg, J. K. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00004.2020 · Cited by 28
Metabolic syndrome prevalence in patients with obstructive sleep apnea syndrome and chronic obstructive pulmonary disease: Relationship with systemic inflammation
Zhou, W., Li, C., Cao, J., & Feng, J. (2020) · The Clinical Respiratory Journal · doi:10.1111/crj.13253 · Cited by 28
Screening for obstructive sleep apnoea in obesity and diabetes – potential for future approaches
Seetho, I. W., & Wilding, J. P. H. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12083 · Cited by 28
Effect of 12‐week continuous positive airway pressure therapy on glucose levels assessed by continuous glucose monitoring in people with type 2 diabetes and obstructive sleep apnoea; a randomized controlled trial
Banghøj, A. M., Krogager, C., Kristensen, P. L., Hansen, K. W., Laugesen, E., Fleischer, J., Cichosz, S. L., Poulsen, P. L., Kirkegaard, M. G., Thorsteinsson, B., et al. (2020) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.148 · Cited by 26
Obstructive sleep apnea and diet-controlled gestational diabetes
Wanitcharoenkul, E., Chirakalwasan, N., Amnakkittikul, S., Charoensri, S., Saetung, S., Chanprasertyothin, S., Chailurkit, L., Panburana, P., Bumrungphuet, S., Ongphiphadhanakul, B., et al. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.08.010 · Cited by 27
Chronic Intermittent Hypoxia Exposure Alternative to Exercise Alleviates High-Fat-Diet-Induced Obesity and Fatty Liver
Luo, Y., Chen, Q., Zou, J., Fan, J., Li, Y., & Luo, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095209 · Cited by 26
Obstructive Sleep Apnea and Abnormal Glucose Metabolism
Kim, N. H. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.4.268 · Cited by 28
Intermittent hypoxia-induced insulin resistance is associated with alterations in white fat distribution
Poulain, L., Mathieu, H., Thomas, A., Borel, A., Rémy, C., Levy, P. A., Arnaud, C., & Demattéis, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-11782-0 · Cited by 27
JCS 2023 Guideline on Diagnosis and Treatment of Sleep Disordered Breathing in Cardiovascular Disease
Kasai, T., Kohno, T., Shimizu, W., Ando, S., Joho, S., Osada, N., Kato, M., Kario, K., Shiina, K., Tamura, A., et al. (2024) · Circulation Journal · doi:10.1253/circj.cj-23-0489 · Cited by 25
Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
Serebrovskaya, T. V., Portnychenko, A. G., Портніченко, В. І., Xi, L., Egorov, E., Antoniuk-Shcheglova, I. A., Наскалова, С., & Shatylo, V. B. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04072-2 · Cited by 25
Obstructive Sleep Apnea, Glucose Tolerance, and β-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study
Mokhlesi, B., Tjaden, A. H., Temple, K. A., Edelstein, S. L., Sam, S., Nadeau, K. J., Hannon, T. S., Manchanda, S., Mather, K. J., Kahn, S. E., et al. (2021) · Diabetes Care · doi:10.2337/dc20-2127 · Cited by 27
Association between sleep disordered breathing in early pregnancy and glucose metabolism
Sanapo, L., Bublitz, M. H., Bai, A., Mehta, N., Messerlian, G. M., Catalano, P., & Bourjeily, G. (2022) · SLEEP · doi:10.1093/sleep/zsab281 · Cited by 25
Hypoxia-Induced Insulin Resistance Mediates the Elevated Cardiovascular Risk in Patients with Obstructive Sleep Apnea: A Comprehensive Review
Adeva‐Andany, M. M., Domínguez-Montero, A., Castro-Quintela, E., Funcasta-Calderón, R., & Fernández‐Fernández, C. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2506231 · Cited by 25
Transcriptome Profiling Reveals the Endogenous Sponging Role of LINC00659 and UST-AS1 in High-Altitude Induced Thrombosis
Jha, P. K., Vijay, A., Prabhakar, A., Chatterjee, T., Nair, V., Bajaj, N., Kumar, B., Sharma, M., & Ashraf, M. Z. (2021) · Thrombosis and Haemostasis · doi:10.1055/a-1390-1713 · Cited by 23
Hypoxic damage to pancreatic beta cells – The hidden link between sleep apnea and diabetes
Pallayová, M., Lazúrová, I., & Donič, V. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.08.016 · Cited by 23
Role of Tissue and Systemic Hypoxia in Obesity and Type 2 Diabetes
Xi, L., Chow, C. M., & Kong, X. (2016) · Journal of Diabetes Research · doi:10.1155/2016/1527852 · Cited by 23
Pharyngeal collapsibility during sleep is elevated in insulin-resistant females with morbid obesity
Llanos, O. L., Galiatsatos, P., Guzmán‐Vélez, E., Patil, S. P., Smith, P. L., Magnuson, T. H., Schweitzer, M., Steele, K. E., Polotsky, V. Y., & Schwartz, A. R. (2016) · European Respiratory Journal · doi:10.1183/13993003.00918-2015 · Cited by 23
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
Wang, X., Yu, Q., Yue, H., Zhang, J., Zeng, S., & Cui, F. (2016) · BioMed Research International · doi:10.1155/2016/9782031 · Cited by 22
Sleep apnea: An overlooked cause of lipotoxicity?
Gu, C., Younas, H., & Jun, J. C. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.09.007 · Cited by 22
Shorter sleep duration is associated with poorer glycemic control in type 2 diabetes patients with untreated sleep-disordered breathing
Siwasaranond, N., Nimitphong, H., Saetung, S., Chirakalwasan, N., Ongphiphadhanakul, B., & Reutrakul, S. (2015) · Sleep And Breathing · doi:10.1007/s11325-015-1243-6 · Cited by 21
Intermittent Hypoxia Alters Gene Expression in Peripheral Blood Mononuclear Cells of Healthy Volunteers
Polotsky, V. Y., Bevans‐Fonti, S., Grigoryev, D. N., & Punjabi, N. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144725 · Cited by 20
Self-citation
Intermittent nocturnal hypoxia and metabolic risk in obese adolescents with obstructive sleep apnea
Narang, I., McCrindle, B. W., Manlhiot, C., Lu, Z., Al‐Saleh, S., Birken, C. S., & Hamilton, J. K. (2018) · Sleep And Breathing · doi:10.1007/s11325-018-1631-9 · Cited by 22
Sleep and diabetes
Ryan, S. (2018) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000524 · Cited by 21
Obstructive sleep apnoea increases lipolysis and deteriorates glucose homeostasis in patients with type 2 diabetes mellitus
Trinh, M. D., Plihalova, A., Gojda, J., Westlake, K., Spicka, J., Lattova, Z., Pretl, M., & Polak, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-83018-1 · Cited by 20
Obstructive Sleep Apnea, Sleepiness, and Glycemic Control in Type 2 Diabetes
Aurora, R. N., & Punjabi, N. M. (2019) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7768 · Cited by 21
Self-citation
Determinants of policy decisions for non-commercial drivers with OSA: An integrative review
Rizzo, D., Libman, E., Creti, L., Baltzan, M., Bailes, S., Fichten, C. S., & Lavigne, G. J. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.02.002 · Cited by 19
Intermittent hypoxia-induced METTL3 downregulation facilitates MGLL-mediated lipolysis of adipocytes in OSAS
Huang, X., Huang, X., Guo, H., Li, J., Zhou, C., Huang, Y., Lai, C., Zeng, W., Tan, X., Niu, L., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01149-4 · Cited by 19
Experimental Models to Study End-Organ Morbidity in Sleep Apnea: Lessons Learned and Future Directions
Farré, R., Almendros, I., Martínez‐García, M. Á., & Gozal, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214430 · Cited by 21
Effects of Positive Airway Pressure Therapy on Glycemic Variability in Patients With Type 2 Diabetes and OSA
Aurora, R. N., Rooney, M. R., Wang, D., Selvin, E., & Punjabi, N. M. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.04.017 · Cited by 19
Self-citation
Effect of Intermittent Hypoxia and Rimonabant on Glucose Metabolism in Rats: Involvement of Expression of GLUT4 in Skeletal Muscle
Wang, X., Yu, Q., Yue, H., Zeng, S., & Cui, F. (2015) · Medical Science Monitor · doi:10.12659/msm.896039 · Cited by 18
Rationale and design of the Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) trial
Rooney, M. R., Aurora, R. N., Wang, D., Selvin, E., & Punjabi, N. M. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.106248 · Cited by 18
Self-citation
The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial
Morin, R., Mauger, J., Amaratunga, R., & Imbeault, P. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02933-z · Cited by 17
Experimentally induced arousals do not elicit periodic leg motor activity during sleep in normal subjects
Ferri, R., Manconi, M., Aricò, D., Punjabi, N. M., & Zucconi, M. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2012.09.021 · Cited by 17
Self-citation
COPD and Type 2 Diabetes
Mamillapalli, C. K., Tentu, R., Jain, N. K., & Bhandari, R. (2019) · Current Respiratory Medicine Reviews · doi:10.2174/1573398x15666190211155640 · Cited by 17
Obstructive sleep apnea is associated with impaired glucose metabolism in Han Chinese subjects
Gu, C., Min, L. I., Li, Q., Li, N., Shi, G., & Wan, H. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20121195 · Cited by 17
Cardiometabolic correlates of sleep disordered breathing in Andean highlanders
Pham, L. V., Miele, C. H., Schwartz, N. G., Arias, R. S., Rattner, A., Gilman, R. H., Miranda, J. J., Polotsky, V. Y., Checkley, W., & Schwartz, A. R. (2017) · European Respiratory Journal · doi:10.1183/13993003.01705-2016 · Cited by 17
The Effect of Hypoxia and Metformin on Fatty Acid Uptake, Storage, and Oxidation in L6 Differentiated Myotubes
Musutova, M., Elkalaf, M., Klubíčková, N., Koc, M., Povysil, S., Rambousek, J., Volckaert, B., Duška, F., Trinh, M. D., Kalous, M., et al. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00616 · Cited by 17
Consequences of Obstructive Sleep Apnea on Metabolic Profile: A Population-Based Survey
Togeiro, S. M., Carneiro, G., Filho, F. F. R., Zanella, M. T., Santos‐Silva, R., Taddei, J. A., Bittencourt, L., & Tufik, S. B. (2012) · Obesity · doi:10.1038/oby.2012.146 · Cited by 17
RAGE/NF-κB pathway mediates hypoxia-induced insulin resistance in 3T3-L1 adipocytes
Tang, Y., Wang, J., Cai, W., & Xu, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.10.076 · Cited by 18
Obstructive Sleep Apnoea and Type 2 Diabetes
Tahrani, A. A., & Ali, A. (2010) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2014.10.01.43 · Cited by 19
Assessing Whether the Association Between Sleep Apnea and Diabetes is Bidirectional
Liu, C., & Wu, C. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.09.009 · Cited by 18
Canvassing the aetiology, prognosis and molecular signatures of obstructive sleep apnoea
Khurana, S., Sharda, S., Saha, B., Kumar, S., Guleria, R., & Bose, S. K. (2018) · Biomarkers · doi:10.1080/1354750x.2018.1514655 · Cited by 18
Epidemiological and pathophysiological evidence supporting links between obstructive sleep apnoea and Type 2 diabetes mellitus
Lee, C., Kushida, C. A., & Abisheganaden, J. A. (2019) · Singapore Medical Journal · doi:10.11622/smedj.2019015 · Cited by 16
The Effect of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Therapy on Skeletal Muscle Lipid Content in Obese and Nonobese Men
König, A. M., Koehler, U., Hildebrandt, O., Schwarzbach, H., Hannemann, L., Boneberg, R., Heverhagen, J. T., Mahnken, A. H., Keller, M., Kann, P. H., et al. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab082 · Cited by 16
Advances in immunology of obstructive sleep apnea: mechanistic insights, clinical impact, and therapeutic perspectives
Dong, N., & Yue, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1654450 · Cited by 18
Effect of chronic intermittent hypoxia on exercise adaptations in healthy subjects
Tonini, J., Michallet, A.-S., Flore, P., Nespoulet, H., Pépin, J., Wuyam, B., Levy, P. A., & Tamisier, R. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.09.006 · Cited by 16
Blockade of Endothelin-1 Receptor Type B Ameliorates Glucose Intolerance and Insulin Resistance in a Mouse Model of Obstructive Sleep Apnea
Polak, J., Punjabi, N. M., & Shimoda, L. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00280 · Cited by 14
Self-citation
Effect of a Prolonged Altitude Expedition on Glucose Tolerance and Abdominal Fatness
Chen, M.-T., Lee, W., Chen, S.-C., Chen, C.-C., Chen, C., Lee, S., Jensen, J., & Kuo, C. (2010) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2010.10599708 · Cited by 15
Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial
Briançon‐Marjollet, A., Netchitaïlo, M., Fabre, F., Belaïdi, E., Arnaud, C., Borel, A., Levy, P. A., Pépin, J., & Tamisier, R. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14243 · Cited by 16
Obstructive Sleep Apnea and Type 2 Diabetes: An Update
Gentile, S., Monda, V. M., Guarino, G., Satta, E., Chiarello, M., Caccavale, G., Mattera, E., Marfella, R., & Strollo, F. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14155574 · Cited by 17
Transcriptomic Changes of Murine Visceral Fat Exposed to Intermittent Hypoxia at Single Cell Resolution
Khalyfa, A., Warren, W. C., Andrade, J., Bottoms, C. A., Rice, E. S., Cortese, R., Gozal, D., & Gozal, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010261 · Cited by 15
Melatonin prevents hyperglycemia in a model of sleep apnea
Kaminski, R. S. R., Martinez, D., Fagundes, M., Martins, E. F., Montanari, C. C., da Rosa, D. P., Fiori, C. Z., & Marroni, N. P. (2015) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000012 · Cited by 14
Glucose Levels in Patients With Acute Respiratory Failure Requiring Mechanical Ventilation
Edriss, H., Selvan, K. C., Sigler, M., & NUGENT, K. M. (2016) · Journal of Intensive Care Medicine · doi:10.1177/0885066616636013 · Cited by 15
Intermittent Hypoxia Stimulates Lipolysis, But Inhibits Differentiation and De Novo Lipogenesis in 3T3-L1 Cells
Musutova, M., Weiszenstein, M., Koc, M., & Polak, J. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2019.0112 · Cited by 14
Oxygen dependence of glucose sensing: role in glucose homeostasis and related pathology
Wilson, D. F., & Matschinsky, F. M. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00047.2019 · Cited by 13
The Effect of Acute Continuous Hypoxia on Triglyceride Levels in Constantly Fed Healthy Men
Mauger, J., Chassé, É., Mahat, B., Lindon, C., Bordenave, N., & Imbeault, P. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00752 · Cited by 13
Obstructive sleep apnea as a risk factor for incident end stage renal disease: a nationwide population-based cohort study from Korea
Choi, H. S., Kim, H. Y., Han, K., Jung, J., Kim, C. S., Bae, E. H., Kwon, S., & Kim, S. W. (2019) · Clinical and Experimental Nephrology · doi:10.1007/s10157-019-01779-6 · Cited by 13
Diabetes and sleep apnea
Tahrani, A. A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch22 · Cited by 14
Insights, recommendations, and research priorities for central sleep apnea: report from an expert panel
Kundel, V., Ahn, A. P., Arzt, M. E., Asin, J., Azarbarzin, A., Collop, N. A., Das, A. M., Fang, J. C., Khayat, R., Penzel, T., et al. (2024) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.11424 · Cited by 13
The impact of high altitude (hypobaric hypoxia) on insulin resistance in humans
Adeva‐Andany, M. M., Adeva-Contreras, L., Carneiro-Freire, N., Ameneiros-Rodríguez, E., Vila-Altesor, M., & Calvo‐Castro, I. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01069-8 · Cited by 14
Heroin Dependence Duration Influences the Metabolic Parameters
Pereska, Z., Bozinovska, C., Dimitrovski, C., Cakalarovski, K., Chibishev, A., Zdravkovska, M., Babulovska, A., & Janicevic, D. (2012) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e31826bd76c · Cited by 12
Intermittent hypoxia as a means to improve aerobic capacity in type 2 diabetes
Leone, R. J., & Lalande, S. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.01.010 · Cited by 12
Articles with impact: insights into 10 years of research with machine learning
van der Zwaard, S., de Leeuw, A., Meerhoff, L. A., Bodine, S. C., & Knobbe, A. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00489.2020 · Cited by 12

Authors: Louis, M., & Punjabi, N. M.
Affiliations: Johns Hopkins University (US)
ORCID: Louis, Mariam
Punjabi, Naresh M.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2009-05
Volume: 106
Issue: 5
Pages: 1538-1544
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.91523.2008
PMC: PMC2681331
OpenAlex: W2153473929
Cited by: 342
References: 40
Citations by year: 2026: 9 · 2025: 13 · 2024: 14 · 2023: 11 · 2022: 14 · 2021: 20 · 2020: 17 · 2019: 17 · 2018: 28 · 2017: 24 · 2016: 30 · 2015: 29 · 2014: 26 · 2013: 28 · 2012: 23
FWCI: 13.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Applied Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research
Institut National de la Santé et de la Recherche Médicale
National Institutes of Health
National Heart, Lung, and Blood Institute (HL-07578)
National Center for Research Resources (UL1RR025005)
Topics: Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: acute intermittent hypoxia, glucose metabolism, obstructive sleep apnea, insulin sensitivity, glucose effectiveness, insulin secretion, glucose tolerance, sympathovagal balance, heart rate variability, cortisol, hypoxic stress, metabolic dysfunction
MeSH terms: Insulin Secretion, Adolescent, Adult, Hypoxia, Blood Glucose, Electrocardiography, Glucose, Glucose Tolerance Test, Heart, Heart Rate, Humans, Insulin, Insulin Resistance, Oxyhemoglobins, Sympathetic Nervous System, Vagus Nerve, Sleep Apnea, Obstructive, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks