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Cited by 1Neural dynamics and brain functionIon channel regulation and functionstochastic dynamics and bifurcation

Sensitivity of a model oscillator to shifts in the voltage-dependence of one or more ionic currents

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Huang, Ian, Alonso, Leandro M., Marder, Eve·2026·Journal of Neurophysiology
DOI 10.1152/jn.00055.2026PMC PMC13637381
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Abstract

We explored the effects of modifying the activation and inactivation curves of currents in a bursting model neuron, in control conditions and in response to depolarizing perturbations. Modifications of the voltage-dependence of one current can result in changes of the contribution of many or all of the currents in the model neuron to its behavior, and can contribute to recovery from perturbations.

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Crossref · 10.1152/jn.00055.2026

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  • Degeneracy can be produced in models with the same types of currents, but different numbers of channels, variable sets of voltage dependences of channels, or as a function of other parameters controlling channel function.

    “Degeneracy can be produced in models with the same types of currents, but different numbers of channels [32,33], variable sets of voltage dependences of channels [35-37], or as a function of other parameters controlling channel function.”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [35]

  • Modulation of voltage-dependence can contribute to resilience subsequent to perturbation.

    “These studies demonstrate that modulation of voltage-dependence can both alter a neuron's activity and contribute to resilience subsequent to perturbation”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [35]

  • Modifications of the voltage-dependence of one current can result in changes of the contribution of many or all of the currents in the model neuron to its behavior.

    “Modifications of the voltage-dependence of one current can result in changes of the contribution of many or all of the currents in the model neuron to its behavior.”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [35]

  • Modulation of voltage-dependence can alter a neuron's activity.

    “These studies demonstrate that modulation of voltage-dependence can both alter a neuron's activity and contribute to resilience subsequent to perturbation”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [35]

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Cited by

Sorted by citations

Authors
Huang, I., Alonso, L. M., & Marder, E.
Affiliations
Brandeis University (US)
Corresponding author
Alonso, Leandro M.
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
2026-08-01
Volume
136
Issue
2
Pages
474-489
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.00055.2026
PMC
PMC13637381
OpenAlex
W7164483683
Cited by
1
References
2
Citations by year
2026: 1
FWCI
3.05
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Neurophysiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (R35NS097343)
  • HHS | National Institutes of Health (R01MH46742)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › stochastic dynamics and bifurcation
Keywords
bursting neurons, ionic currents, voltage dependence, sensitivity analysis, model neurons
MeSH terms
Action Potentials, Animals, Computer Simulation, Ion Channels, Models, Neurological, Neurons, Potassium

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