The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Layer V Neurons in Mouse Cortex Projecting to Different Targets Have Distinct Physiological Properties
Abstract
Layer V pyramidal neurons are anatomically and physiologically heterogeneous and project to multiple intracortical and subcortical targets. However, because most physiological studies of layer V pyramidal neurons have been carried out on unidentified cells, we know little about how anatomical and physiological properties relate to subcortical projection site. Here we combine neuroanatomical tract tracing with whole cell recordings in mouse somatosensory cortex to test whether neurons with the same projection target form discrete subpopulations and whether they have stereotyped physiological properties. Our findings indicate that corticothalamic and -trigeminal neurons are two largely nonoverlapping subpopulations, whereas callosal and corticostriatal neurons overlap extensively. The morphology as well as the intrinsic membrane and firing properties of corticothalamic and corticotrigeminal neurons differ from those of callosal and corticostriatal neurons. In addition, we find that each class of projection neuron exhibits a unique compliment of hyperpolarizing and depolarizing afterpotentials that further suggests that cortical neurons with different subcortical targets are distinct from one another.
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Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick, D. A., Connors, B. W., Lighthall, J. W., & Prince, D. A. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.4.782 · Cited by 1,933
Natural waking and sleep states: a view from inside neocortical neurons
Steriade, M., Timofeev, I., & Grenier, F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.5.1969 · Cited by 1,296
Tamamaki, N., Yanagawa, Y., Tomioka, R., Miyazaki, J., Obata, K., & Kaneko, T. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10905 · Cited by 1,277
Unbiased Stereology: Three-Dimensional Measurement in Microscopy
Howard, C. V., & Reed, M. (1998) · Cited by 1,149
Recurrent Excitation in Neocortical Circuits
Douglas, R. J., Koch, C., Mahowald, M., Martin, K. A. C., & Suarez, H. H. (1995) · Science · doi:10.1126/science.7638624 · Cited by 980
Electrophysiological properties of neocortical neurons in vitro
Connors, B. W., Gutnick, M. J., & Prince, D. A. (1982) · Journal of Neurophysiology · doi:10.1152/jn.1982.48.6.1302 · Cited by 935
Katz, L. C., Burkhalter, A., & Dreyer, W. J. (1984) · Nature · doi:10.1038/310498a0 · Cited by 601
Wise, S. P., & Jones, E. G. (1977) · Journal of Comparative Neurology · doi:10.1002/cne.901750202 · Cited by 524
Chagnac‐Amitai, Y., Luhmann, H. J., & Prince, D. A. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960407 · Cited by 426
Multiple potassium conductances and their functions in neurons from cat sensorimotor cortex in vitro
Schwindt, P. C., Spain, W. J., Foehring, R. C., Stafstrom, C. E., Chubb, M. C., & Crill, W. E. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.59.2.424 · Cited by 378
Cited by
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934
Corticostriatal connectivity and its role in disease
Shepherd, G. M. G. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3469 · Cited by 824
Classification of electrophysiological and morphological neuron types in the mouse visual cortex
Gouwens, N. W., Sorensen, S. A., Berg, J., Lee, C., Jarsky, T., Ting, J., Sunkin, S. M., Feng, D., Anastassiou, C. A., Barkan, E., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0417-0 · Cited by 456
Long-range connectivity defines behavioral specificity of amygdala neurons
Senn, V., Wolff, S. B. E., Herry, C., Grenier, F., Ehrlich, I., Gründemann, J., Fadok, J. P., Müller, C., Letzkus, J. J., & Lüthi, A. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.006 · Cited by 522
Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex
Hrvatin, S., Hochbaum, D. R., Nagy, M. A., Cicconet, M., Robertson, K., Cheadle, L., Zilionis, R., Ratner, A., Borges-Monroy, R., Klein, A. M., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0029-5 · Cited by 497
Metadata
- Authors
- Hattox, A. M., & Nelson, S. B.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2007-12
- Volume
- 98
- Issue
- 6
- Pages
- 3330-3340
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1986287415
- Cited by
- 342
- References
- 64
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
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