Corticostriatal connectivity and its role in disease
Open accessAbstract
Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevelopmental, neuropsychiatric and movement disorders - autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.
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Anatomically, investigations have revealed reduced gray matter volume in the anterior cingulate cortex, caudate nucleus and putamen in MDD.
“Anatomically, investigations have revealed reduced gray matter volume in the anterior cingulate cortex, caudate nucleus, putamen (Bora et al., 2012; Shepherd, 2013).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Shepherd, 2013
Certain genes that impart increased risk of developing schizophrenia are associated with decreased striatal volume and hyperconnectivity within frontostriatal loops.
“Additionally, certain genes that impart increased risk of developing schizophrenia have been associated with decreased striatal volume and hyperconnectivity within frontostriatal loops (Shepherd, 2013).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Shepherd, 2013
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- Authors
- Shepherd, G. M. G.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Shepherd, Gordon M. G.
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-03-20
- Volume
- 14
- Issue
- 4
- Pages
- 278-291
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC4096337
- OpenAlex
- W2032996762
- Cited by
- 824
- References
- 202
- Citations by year
- 2026: 41 · 2025: 58 · 2024: 81 · 2023: 74 · 2022: 69 · 2021: 67 · 2020: 76 · 2019: 68 · 2018: 63 · 2017: 65 · 2016: 61 · 2015: 49 · 2014: 31 · 2013: 20
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS061963, R01NS061963, R37NS061963)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- corticostriatal pathway, intratelencephalic neurons, pyramidal tract neurons, cortical pyramidal neurons, motivated behavior, autism spectrum disorder, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's disease, Parkinson's disease, major depressive disorder, neurodevelopmental disorders, neuropsychiatric disorders, movement disorders
- MeSH terms
- Animals, Mental Disorders, Cerebral Cortex, Developmental Disabilities, Corpus Striatum, Humans, Movement Disorders, Neural Pathways, Neurons
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