Cited by 824Neuroscience and Neuropharmacology ResearchNeurological disorders and treatmentsMemory and Neural Mechanisms

Corticostriatal connectivity and its role in disease

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Shepherd, Gordon M. G.·2013·Nature Reviews Neuroscience

Abstract

Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevelopmental, neuropsychiatric and movement disorders - autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.

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Authors
Shepherd, G. M. G.
Affiliations
Northwestern University (US)
Corresponding author
Shepherd, Gordon M. G.
Venue
Nature Reviews Neuroscience
Published
2013-03-20
Volume
14
Issue
4
Pages
278-291
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2032996762
Cited by
824
References
202
Citations by year
2026: 41 · 2025: 58 · 2024: 81 · 2023: 74 · 2022: 69 · 2021: 67 · 2020: 76 · 2019: 68 · 2018: 63 · 2017: 65 · 2016: 61 · 2015: 49 · 2014: 31 · 2013: 20
FWCI
5.46
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS061963, R01NS061963, R37NS061963)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
corticostriatal pathway, intratelencephalic neurons, pyramidal tract neurons, cortical pyramidal neurons, motivated behavior, autism spectrum disorder, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's disease, Parkinson's disease, major depressive disorder, neurodevelopmental disorders, neuropsychiatric disorders, movement disorders
MeSH terms
Animals, Mental Disorders, Cerebral Cortex, Developmental Disabilities, Corpus Striatum, Humans, Movement Disorders, Neural Pathways, Neurons

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