The DOI matches its Crossref record.
Anomalous inward rectification in hippocampal neurons
Abstract
1. Anomalous rectification occurred in 54 of 56 hippocampal CA1 neurons studied in vitro. This phenomenon is characterized by a progressive increase in input resistance with membrane depolarization. An average increase in membrane resistance of 45% occurred over a 15-mV region of membrane potential immediately subthreshold to cellular firing. 2. Both Mn2+, a Ca+ antagonist, and tetrodotoxin (TTX), a neurotoxin that blocks regenerative Na+ currents, eliminated anomalous rectification. Ba2+, which can both contribute to intracellular cation influx as well as reduce K+ conductance, increased the magnitude of anomalous rectification. The observations are indirect evidence indicating that a Ca2+-Na+ current may produce the inward-going rectification. 3. Enhancement of anomalous rectification by Ba2+ was associated with the onset of membrane oscillations and spontaneous bursts of repetitive discharges. The magnitude of anomalous rectification may be one factor that predisposes some cortical neurons to bursting behavior.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Llinás, R. R. (1988) · Science · doi:10.1126/science.3059497 · Cited by 2,285
Voltage-clamp analysis of muscarinic excitation in hippocampal neurons
Halliwell, J. V., & Adams, P. R. (1982) · Brain Research · doi:10.1016/0006-8993(82)90954-4 · Cited by 1,041
Chapter 12 Potassium currents in hippocampal pyramidal cells
Storm, J. F. (1990) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61248-0 · Cited by 743
Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons
Raman, I. M., & Bean, B. P. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04517.1997 · Cited by 568
Excitatory synaptic interactions between CA3 neurones in the guinea‐pig hippocampus.
Miles, R., & Wong, R. K. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016055 · Cited by 503
Metadata
- Authors
- Hotson, J. R., Prince, D. A., & Schwartzkroin, P. A.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1979-05-01
- Volume
- 42
- Issue
- 3
- Pages
- 889-895
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2412113717
- Cited by
- 247
- References
- 0
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Anomalous inward rectification in hippocampal neurons. https://app.cochat.ai/papers/10.1152/jn.1979.42.3.889
- The paper
- Hotson, J. R., Prince, D. A., & Schwartzkroin, P. A. (1979). Anomalous inward rectification in hippocampal neurons. Journal of Neurophysiology. https://doi.org/10.1152/jn.1979.42.3.889
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
