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REM sleep burst neurons, PGO waves, and eye movement information.
Abstract
Pontogeniculooccipital (PGO) waves appeared almost simultaneously in both lateral geniculate nuclei (LGB), but in each case on had a larger amplitude and preceded the other by a few milliseconds. The larger, earlier wave is called the primary wave. Primary waves were found to appear with equal frequency in each LGB. During rapid eye movement sleep (REM sleep), LGB primary waves were ipsilateral to the direction of rapid eye movements. During REM sleep a group of cat midbrain neurons, which we call PGO burst cells, fired in stereotyped bursts at fixed latencies before ipsilateral primary waves, but they almost never fired bursts when the primary waves were contralateral. PGO burst neuron discharge also correlated with the direction of rapid eye movements during REM sleep. In wakefulness, PGO burst cells fired single spikes, not bursts, which had some correlation with LGB waves when averaged by computer. The results suggest that PGO burst cells are output elements in the PGO wave-generation system ad that PGO waves convey eye movement information to the sensory visual system in REM sleep. They also may have a role in the production of saccade-related waves in the visual system during wakefulness.
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“REMs are accompanied by PGO waves (Nelson et al., 1983).”
From Virtual reality and consciousness inference in dreaming (2014) · cites this paper as Nelson et al., 1983
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“In contrast, single cell recording studies in animals have established that PGO waves that are coupled with REMs (Nelson et al., 1983).”
From Virtual reality and consciousness inference in dreaming (2014) · cites this paper as Nelson et al., 1983
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Metadata
- Authors
- Nelson, J. P., McCarley, R. W., & Hobson, J. A.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1983-10-01
- Volume
- 50
- Issue
- 4
- Pages
- 784-797
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1832983298
- Cited by
- 190
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 2
- FWCI
- 11.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- PGO waves, REM sleep, lateral geniculate nucleus, eye movements, saccades, midbrain neurons
- MeSH terms
- Action Potentials, Animals, Cats, Evoked Potentials, Eye Movements, Geniculate Bodies, Neurons, Occipital Lobe, Pons, Sleep, REM, Wakefulness
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