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Effects of aging, hearing loss, and anatomical location on thresholds of inferior colliculus neurons in C57BL/6 and CBA mice
Abstract
Multiple-unit threshold curves (MTCs) were obtained from inferior colliculus (IC) neurons across much of the (approximately 2-2.5 yr) life-span of two inbred mouse strains: the C57BL/6, which undergoes progressive age-related sensorineural hearing loss; and the CBA, which maintains good sensitivity until well into the second year of life. Tonotopic organization (the orderly dorsoventral arrangement of frequency sensitivity) is disrupted in the IC central nucleus (ICC) of aging C57 mice. Dorsal (low-frequency) MTCs change little during the first year of life, but in more ventral (high-frequency) regions high-frequency portions of MTCs are eliminated, best frequencies become lower, and low-frequency thresholds are reduced. These changes make the curves more similar to one another along the dorsoventral axis. During the second year of life, all thresholds become greatly elevated with neurons throughout the IC responding only to middle frequencies at very high intensities. In C57 mice, Q10 ratios (a measure of MTC tip sharpness) decline after 7 mo. The decline of Q10 with aging is associated with the age-related lowering of best frequencies and elevation of thresholds, both of which are positively correlated with smaller Q10s. The frequency range of C57 MTCs begins to decrease at 14 mo of age, when hearing loss is quite severe at all frequencies. In CBA mice, the above changes are minimal or do not occur even in 22 mo olds, which have moderate loss of sensitivity across all frequencies. Even in young mice (prior to demonstrable cochlear pathology in C57 mice), there are differences in MTCs between the two strains employed, with sensitivity of CBA mice being "shifted" toward higher frequencies. Age-related changes in MTC properties depend on the pattern of hearing loss (e.g., high frequency vs. flat) and the dorsoventral location of neurons within the ICC.
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“As there is a well-characterized loss of hearing around 7 months of age in the C57BL/6J strain [46–50]”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [48]
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Incidence of otitis media in CBA/J and CBA/CaJ mice
McGinn, M. D., Bean-Knudsen, D., & Ermel, R. W. (1992) · Hearing Research · doi:10.1016/0378-5955(92)90094-4 · Cited by 40
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“, severe hearing loss at 9–12 months of age [9, 15, 21, 36].”
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McFadden, S. L., & Willott, J. F. (1994) · Hearing Research · doi:10.1016/0378-5955(94)90018-3 · Cited by 37
Self-citationPaciello, F., Pisani, A., Rinaudo, M., Cocco, S., Paludetti, G., Fetoni, A. R., & Grassi, C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106024 · Cited by 37
“culus (Willott, 1986; Caspary et al., 2008; Ouda and Syka, 2012), we cannot exclude that functional, morphological, and molecular changes observed here in ACx and HP are associated also with maladaptive modifications in the brainstem and midbrain nuclei of the auditory”
Musicians change their tune: How hearing loss alters the neural code
Parbery‐Clark, A., Anderson, S., & Kraus, N. (2013) · Hearing Research · doi:10.1016/j.heares.2013.03.009 · Cited by 39
“Auditory deprivation , such as that associated with hearing loss , alters the response properties of neurons ( Willott , 1984 , 1986 ; Yang et al .”
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“Previous electrophysiological studies show that the C57 mice develop high-frequency loss from 3 to 6 mo (Henry and Chole 1980; Hunter and Willott 1987; Mikaelian 1979; Willott 1986) with a loss of outer hair cells in the basal 20% of the cochlea present from 3 mo of age (Spongr et al. 1997).”
BackgroundFelix, R. A., & Portfors, C. V. (2007) · Hearing Research · doi:10.1016/j.heares.2007.02.009 · Cited by 36
“By 6 months, not only is sensitivity to high frequencies lost, but tonotopy in the IC has been reorganized (Willott, 1984;Willott, 1986).”
BackgroundMethodInfluentialAuditory Cortical Areas Activated by Slow Frequency-Modulated Sounds in Mice
Honma, Y., Tsukano, H., Horie, M., Ohshima, S., Tohmi, M., Kubota, Y., Takahashi, K., Hishida, R., Takahashi, S., & Shibuki, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068113 · Cited by 36
“Adult C57BL/6 mice exhibit hearing loss at higher frequencies [54], [55], [56], and these mice respond to tonal stimuli up to 40 kHz [26], but not to ultrasonic sounds higher than 40 kHz.”
BackgroundSensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons
Shen, Y., Hu, H., Cui, F., Wang, Q., Zou, T., Ye, B., & Xiang, M. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105408 · Cited by 36
“However, early inner and outer hair cell loss does not lead to hearing loss in C57 mice, and these mice do not exhibit hearing loss at high frequency until 6–8 months of age (Hunter and Willott, 1987; Willott, 1986).”
Central physiological correlates of ageing and presbycusis in mice
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Self-citationFVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise
Gibb, A., McNally, L. A., Riggs, D. W., Conklin, D. J., Bhatnagar, A., & Hill, B. G. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00636 · Cited by 36
“Of note, while FVB/NJ mice are blind, C57BL/6J mice become deaf, progressively losing their hearing during the first year of life (Mikaelian, 1979; Henry and Chole, 1980; Willott, 1986).”
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Pearce, M., Richter, C., & Cheatham, M. A. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00329-6 · Cited by 34
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“The frequency shift, which has been shown previously by Willott (1986), is reminiscent to the tonotopic map reorganization seen in the AC after noise induced hearing loss (Engineer et al., 2011; Roberts et al., 2010).”
Aging Processes in the Subcortical Auditory System
Caspary, D. M., & Llano, D. A. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190849061.013.16 · Cited by 31
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Self-citationFrisina, R. D., Walton, J. P., Lynch-Armour, M. A., & Klotz, D. A. (1997) · The Journal of the Acoustical Society of America · doi:10.1121/1.418562 · Cited by 28
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Aging and presbycusis: Effects on 2-deoxy-d-glucose uptake in the mouse auditory brain stem in quiet
Willott, J. F., Hunter, K. P., & Coleman, J. R. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90178-1 · Cited by 27
Self-citationAnatomical and Neurochemical Bases of Presbycusis
Frisina, R. D. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50039-1 · Cited by 25
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Barsz, K., Wilson, W. W., & Walton, J. P. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.031 · Cited by 24
“Indeed, these increases in sensitivity to low-frequency tones could be accounted for by changes in the central auditory system detailed in the pioneering work of Willott and colleagues (Willott et al., 1984a, Willott, 1986, Willott et al., 1988, Willott et al., 1991, Willott et al., 1993).”
BackgroundMethodResultInfluentialThree-dimensional tonotopic organization of the C57 mouse cochlear nucleus
Luo, F., Wang, Q., Farid, N., et al. (2009) · Hearing Research · doi:10.1016/j.heares.2009.08.002 · Cited by 23
Cell Biology and Physiology of the Aging Central Auditory Pathway
Canlon, B., Illing, R., & Walton, J. P. (2009) · Springer handbook of auditory research · doi:10.1007/978-1-4419-0993-0_3 · Cited by 23
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“C57BL/6J mice are also widely used as models of presbycusis due to their Ahl/Ahl2 genes which accelerate age-related hearing loss (20,165-171).”
MethodHow Well Can Centenarians Hear?
Mao, Z., Zhao, L., Lichun, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065565 · Cited by 21
“Other animal studies have shown decreased function in the cochlear nucleus [50,51].”
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Leong, U.-C., Barsz, K., Allen, P. D., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.01.006 · Cited by 21
Kazee, A. M., & West, N. R. (1999) · Hearing Research · doi:10.1016/s0378-5955(99)00058-1 · Cited by 21
Inferior Colliculus: Aging and Plasticity
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Identifying MicroRNAs Involved in Aging of the Lateral Wall of the Cochlear Duct
Zhang, Q., Liu, H., Soukup, G. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112857 · Cited by 19
“We are fully aware that neither mouse strain shows a stria-originated ARHL.”
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Self-citationHorst, N. K., Heath, C. J., Neugebauer, N. M., Kimchi, E. Y., Laubach, M., & Picciotto, M. R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.002 · Cited by 17
Age-related changes of auditory sensitivity across the life span of CBA/CaJ mice
Park, C. R., Willott, J. F., & Walton, J. P. (2023) · Hearing Research · doi:10.1016/j.heares.2023.108921 · Cited by 18
Self-citationTrujillo, M. S., Carrasco, M. M., & Razak, K. A. (2013) · Hearing Research · doi:10.1016/j.heares.2012.12.013 · Cited by 18
“This strain shows accelerated age-related hearing loss (Henry and Chole, 1980; Hunter and Willott, 1987; Mikaelian, 1979; Spongr et al., 1997; Willott, 1986).”
Malmierca, M. S., & Ryugo, D. K. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-369497-3.10024-x · Cited by 17
“Humans suffering from presbycusis share this same hearing loss pattern (Willott, 1986).”
Oliver, D. L., Beckius, G. E., & Ostapoff, E. ‐. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90140-6 · Cited by 18
The Mouse, a Model Organism for Biomedical Research
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Development of response selectivity in the mouse auditory cortex
Carrasco, M. M., Trujillo, M. S., & Razak, K. A. (2012) · Hearing Research · doi:10.1016/j.heares.2012.11.020 · Cited by 16
“This mouse strain shows accelerated age-related hearing loss with audiometric evidence for hearing loss from around P90 (Henry and Chole, 1980; Hunter and Willott, 1987; Mikaelian, 1979; Spongr et al., 1997; Willott, 1986).”
BackgroundInfluentialAge-dependent changes of calcium related activity in the central auditory pathway
Gröschel, M., Hubert, N. D., Müller, S., Ernst, A., & Basta, D. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.08.014 · Cited by 16
“Further, tonotopic reorganization was shown, indicating the appearance of central neuroplasticity (Willott, 1984, 1986).”
Mismatch of structural and functional tonotopy for natural sounds in the auditory midbrain
Portfors, C. V., & Roberts, P. D. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.012 · Cited by 15
“We used this strain because it exhibits normal hearing sensitivity well into its second year of life (Willott, 1986, 1991).”
Shim, H. J., Lee, L. H., Huh, Y., et al. (2011) · Acta Oto-Laryngologica · doi:10.3109/00016489.2011.622785 · Cited by 14
“As high-frequency sensitivity in C57 mice declined as a result of cochlear pathology, the tonotopy of the ventral IC and auditory cortex changed; the best frequency of ventral IC neurons and auditory cortex shifted from high to middle frequencies [8,20].”
Background2-Deoxyglucose uptake patterns in response to pure tone stimuli in the aged rat inferior colliculus
Keithley, E. M., Lo, J., & Ryan, A. F. (1994) · Hearing Research · doi:10.1016/0378-5955(94)90011-6 · Cited by 14
Konishi, H., Ohgami, N., Matsushita, A., Kondo, Y., Aoyama, Y., Kobayashi, M., Nagai, T., Ugawa, S., Yamada, K., Kato, M., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.03.028 · Cited by 13
“5), which does not have the genetic mutation and is highly resistant to age-related hearing loss (Willott, 1986; Ohlemiller et al., 2010).”
Context Processing in Aging: Older Mice Are Impaired in Renewal of Extinguished Fear
Sanders, M. J. (2011) · Experimental Aging Research · doi:10.1080/0361073x.2011.619874 · Cited by 14
“Between 14 and 20 months of age, the strain suffers additional deficits in responses to lower-frequency tones (Willott, 1986).”
BackgroundMethodInfluentialTargeted Mutagenesis of the Murine Opioid System
Hayward, M. D., & Low, M. J. (1999) · Results and problems in cell differentiation · doi:10.1007/978-3-540-49421-8_8 · Cited by 13
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Clinkard, D., Amoodi, H. A., Kandasamy, T., et al. (2013) · ISRN Otolaryngology · doi:10.1155/2013/430625 · Cited by 12
“Like humans, histopathological alterations are first seen in the basal turn which progress to the apical turns as these animals first lose their outer and later inner hair cells [6].”
BackgroundRoyer, J., Huetz, C., Occelli, F., Cancela, J., & Edeline, J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.031 · Cited by 12
“Initially, many studies that have investigated the neural bases of pup call detection and discrimination have used the CBA/CaJ mouse strain which is known to have good hearing and show moderate age-related hearing loss until almost 2 years old (Willott, 1986; Willot et al. 1991; Walton et al. 1998).”
BackgroundModulation of prepulse inhibition by an augmented acoustic environment in DBA/2J mice.
Jeskey, J. E., & Willott, J. F. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.5.991 · Cited by 13
Self-citationSabesan, S., Fragner, A., Bench, C. A., Drakopoulos, F., & Lesica, N. A. (2023) · eLife · doi:10.7554/elife.85108 · Cited by 12
“…is consistent with the increased similarity of spectral tuning between individual IC neurons in animals with hearing loss ( Barsz et al., 2007 ; Willott, 1986 ), but the clustering of dynamics within the signal manifold is an emergent network-level phenomenon that has not previously been…”
BackgroundAge-dependent structural reorganization of utricular ribbon synapses
Michanski, S., Henneck, T., Mukhopadhyay, M., Steyer, A. M., Agüi‐Gonzalez, P., Grewe, K., Ilgen, P., Gültaş, M., Fornasiero, E. F., Jakobs, S., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1178992 · Cited by 11
“These mice maintain relatively normal 306 hearing until they reach senescence (Shone et al., 1991; Spongr et al., 1997; Walton 307 et al., 1995; Willott, 1986; Willott et al., 1988a; Willott et al., 1988b).”
BackgroundMajumder, P., Blacker, T. S., Nolan, L. S., Duchen, M. R., & Gale, J. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-55329-x · Cited by 10
Auditory degeneration after exposure to toluene in two genotypes of mice
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Vacuolar neuritic dystrophy in aged mouse superior cervical sympathetic ganglia is strain-specific
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“The age range of the mice was selected on the basis that the animals would have matured, but would not have developed age‐associated peripheral hearing deficits (Hunter & Willott, 1987; Sergeyenko et al., 2013; Spongr, Flood, Frisina, & Salvi, 1997; Willott, 1986).”
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Modulation of prepulse inhibition by an augmented acoustic environment in DBA/2J mice.
Jeskey, J. E., & Willott, J. F. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.5.991 · Cited by 10
Self-citationBehavior and brain uptake of fluorodeoxyglucose in mature and aged C57BL/6 mice
Uecker, A. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00099-3 · Cited by 11
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“Another very important finding is that the tonotopic maps of the IC (Willott 1986) and the auditory cortex (Willott et al.”
BackgroundInfluentialAge-related morphological changes in the hippocampus in two mouse strains
Barkats, M., Bertholet, J.-Y., & Cohen‐Salmon, C. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01702-x · Cited by 8
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Severe hearing loss in Dlx1 mutant mice
Polley, D. B., Cobos, I., Merzenich, M. M., et al. (2006) · Hearing Research · doi:10.1016/j.heares.2006.02.008 · Cited by 8
“The lack of a threshold difference at 32 kHz may be attributable to a diminished sensitivity to high-frequency sounds that is known to occur in C57BL/6J mice irrespective of the Dlx1 mutation rather than a partial sparing of hearing thresholds in Dlx / mice (Henry and Chole, 1980; Willott, 1986).”
BackgroundInterventions and Future Therapies: Lessons from Animal Models
Willott, J. F., & Schacht, J. (2009) · Springer handbook of auditory research · doi:10.1007/978-1-4419-0993-0_10 · Cited by 7
Self-citationAnimal Models of Presbycusis and the Aging Auditory System
Willott, J. F. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50044-5 · Cited by 7
Self-citationVolume electron microscopy reveals age-related circuit remodeling in the auditory brainstem
Charan, D. C., Hua, Y., Wang, H., Huang, W.-Q., Wang, F., Elgoyhen, A. B., Boergens, K. M., & Guilmi, M. N. D. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1070438 · Cited by 6
“This model has also been extensively studied because of the presence of a type of age-related hearing loss (Henry and Lepkowski, 1978; Willott, 1986; Li et al., 1993; Taberner and Liberman, 2005).”
BackgroundMethodHearing Loss and the Inferior Colliculus
Willott, J. F. (2005) · Springer eBooks · doi:10.1007/0-387-27083-3_20 · Cited by 6
Self-citationMorphology, GluR1 and GRIP-C localization differ in octopus cells of C57BL6 and B6Cast mice
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Neurophysiological Manifestations of Aging in the Peripheral and Central Auditory Nervous System
Walton, J. P., & Burkard, R. F. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50042-1 · Cited by 5
Brief periods of visual deprivation in adults increase performance on auditory tasks
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“29 Mechanistically, our behavioral data could be explained by the circuit-level plasticity we reported in previous studies.”
Rawool, V. W. (2001) · Scandinavian Audiology · doi:10.1080/010503901300112202 · Cited by 4
“Willott (1984) demonstrated that as C57 mice begin to have an age-related hearing loss in the higher frequencies, neurons in the high-frequency tonotopic region become responsive to the middle and lower frequencies that remain audible.”
BackgroundMethodTakeda, S., Mannström, P., Dash-Wagh, S., et al. (2017) · Neurophysiology · doi:10.1007/s11062-018-9691-9 · Cited by 3
Changes in the Inferior Colliculus Associated with Hearing Loss
Palmer, A. R., & Berger, J. I. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190849061.013.20 · Cited by 3
Lifespan changes in cannabinoid 1 receptor mRNA expression in the female C57BL/6J mouse brain
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“The IC is related to auditory sensation and undergoes degeneration with age in both humans and rodents (Caspary et al., 1995; Willott, 1986).”
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“Mice of the C57BL/6J strains have peripheral hearing loss in young adulthood (Henry and Chole, 1980; Willott, 1986; Spongr et al., 1997) and show a remapping of ACtx in response to peripheral hearing loss (Willott et al., 1993).”
Central auditory plasticity in mouse models of progressive sensorineural hearing loss
Willott, J. F. (2006) · doi:10.1093/acprof:oso/9780198528999.003.0009 · Cited by 3
Self-citationSound preferences in mice are sex dependent
Sehrawat, K., & Nelken, I. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116454 · Cited by 3
Crusio, W. E., Sluyter, F., Gerlai, R. T., & Pietropaolo, S. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139541022.006 · Cited by 2
The Aging Central Auditory System
Maclaine, K. D., & Llano, D. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.24174-6 · Cited by 2
Luo, Y., Wei, G., Lou, Y., Wang, Z., Yan, X., Chen, P., & Wen, H. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107394 · Cited by 1
Cortical Effects of Aging and Hearing Loss
Mendelson, J. R., & Rajan, R. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0074-6_23 · Cited by 1
Furutani, A., Asama, Y., Sasaki, H., et al. (2019) · JMA Journal · doi:10.31662/jmaj.2018-0067 · Cited by 1
“Although unrelated to coat pigmentation, our results regarding hearing in young adulthood are consistent with previous, ground-breaking research performed in older mice, which showed that several inbred strains exhibit hearing impairments from middle age, unlike F1 hybrids (14), (21), ((22)).”
Descending control of responses in the auditory midbrain
Seluakumaran, K. (2007) · UWA Profiles and Research Repository (University of Western Australia) · Cited by 1
Dark exposure reduces high-frequency hearing loss in C57BL/6J micePreprint
Jendrichovsky, P., Lee, H., & Kanold, P. O. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.02.592252 · Cited by 1
“Such degeneration results in reduced ascending sound-evoked activity and subsequently reduced activation of the auditory cortex for high-frequency stimuli (29).”
BackgroundMethods for Studying Hearing Impairment and Auditory Problems of the Aged
Frisina, R. D., & Frisina, R. D. (2006) · Elsevier eBooks · doi:10.1016/b978-012369391-4/50077-1
Adenosine Production Is Essential for Closing the Critical Period of Cortical Plasticity
Chassan, R. A. (2014) · doi:10.21007/etd.cghs.2014.0049
“Ages of the mice ranged from P35 to P90, before any high frequency hearing loss can occur in C57BL/6 (Willott, 1986).”
Behavioral Phenotyping of VMAT1 Knockout Mice: Relevance to Neuropsychiatric Disorders
Webster (2016) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/fnn2-hq83
Metadata
- Authors
- Willott, J. F.
- Corresponding author
- Willott, J. F.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1986-08-01
- Volume
- 56
- Issue
- 2
- Pages
- 391-408
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1921685703
- Cited by
- 211
- References
- 0
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 13 · 2012: 7
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k04ag000234-05)
- National Institute on Aging (KO4-AG-00234, R01-AG-03069)
- National Center for Research Resources (RR07176)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Health Sciences › Health Professions › Speech and Hearing › Hearing Loss and Rehabilitation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- inferior colliculus, age-related hearing loss, sensorineural hearing loss, tonotopic organization, characteristic frequency, Q10, central nucleus of inferior colliculus, anatomical location, C57BL/6 mice, CBA mice, mouse strain differences, auditory sensitivity, auditory brainstem
- MeSH terms
- Acoustic Stimulation, Aging, Animals, Auditory Pathways, Hearing Loss, Sensorineural, Inferior Colliculi, Male, Mice, Inbred CBA, Mice, Inbred C57BL, Mice, Inbred Strains, Neurons, Afferent, Sensory Thresholds, Species Specificity, Mice
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