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Urge to scratch represented in the human cerebral cortex during itch
Abstract
1. We used functional positron emission tomography (PET), measuring regional cerebral blood flow (rCBF) as an index of neuronal activity, to investigate the central processing of itch in 10 healthy volunteers subjected to intracutaneous injections of histamine. 2. The study has unraveled a central representation that depicts a motor intention of the urge to scratch contingent on the perception of unpleasant itch. The coactivation of the anterior cingulate cortex (ACC), supplementary motor area (SMA), premotor area (PM), and inferior parietal lobule (IPL) substantiates that the posterior sector of the ACC (Brodmann 24) is related to the sensorial/affectional aspect of the event. The premotor cortical areas (SMA, PM) and the IPL may participate in the preparation of an intended action.
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“Thus, we suggest that the activity in SMA and pre-SMA in the present study reflects an urge to withdraw the hand, rather than anxiety, because this activity was not correlated with the anxiety ratings.”
From Threatening a rubber hand that you feel is yours elicits a cortical anxiety response. (2007) · cites this paper as [29]
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Botvinick, M. M., Braver, T. S., Barch, D. M., Carter, C. S., & Cohen, J. D. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.624 · Cited by 7,351
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171
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Hsieh, J., Belfrage, M., Stone‐Elander, S., Hansson, P. T., & Ingvar, M. (1995) · Pain · doi:10.1016/0304-3959(95)00048-w · Cited by 644
“3) (Paus et al. 1993; Hsieh et al. 1994), lying along and /or dorsal to the cingulate sulcus, sits above the "pain and itch' cluster and is clearly demarcated from the latter one.”
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Metadata
- Authors
- Hsieh, J. C., Hagermark, O., Stahle-Backdahl, M., Ericson, K., Eriksson, L., Stone-Elander, S., & Ingvar, M.
- Affiliations
- Karolinska Institutet (SE)
- Department of Clinical Neuroscience, Karolinska Institute/Hospital,Stockholm, Sweden.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1994-12-01
- Volume
- 72
- Issue
- 6
- Pages
- 3004-3008
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1902361870
- Cited by
- 237
- References
- 0
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 9
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- pruritus, anterior cingulate cortex, supplementary motor area, premotor cortex, inferior parietal lobule, regional cerebral blood flow, histamine, action preparation, motor intention
- MeSH terms
- Adult, Cerebral Cortex, Cerebrovascular Circulation, Histamine, Humans, Image Processing, Computer-Assisted, Middle Aged, Pruritus, Tomography, Emission-Computed
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