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Cited by 144Neuroscience of respiration and sleepNeuroscience and Neuropharmacology ResearchIon channel regulation and function

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Spike-frequency adaptation studied in hypoglossal motoneurons of the rat

Sawczuk, A., Powers, R. K., Binder, M. D.·1995·Journal of Neurophysiology
DOI 10.1152/jn.1995.73.5.1799
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Abstract

1. We studied spike frequency adaptation of motoneuron discharge in the rat hypoglossal nucleus using a brain stem slice preparation. The characteristics of adaptation in response to long (60 s) injected current steps were qualitatively similar to those observed previously in cat hindlimb motoneurons. The discharge rate typically exhibited a rapid initial decline, characterized by a linear frequency-time relation, followed by a gradual exponential decline that continued for the duration of current injection. However, a more systematic, quantitative analysis of the data revealed that there were often three distinct phases of the adaptation rather than two. 2. The three phases of adaptation (initial, early, and late) were present in at least one 60-s trial of repetitive firing in all but a small number of motoneurons. Initial adaptation was limited to the first few spikes except in a few trials (7%) in which there was no initial adaptation. The time course of the subsequent decline in rate could be adequately described by a single-exponential function in about half of the trials (48%). In the remaining trials this subsequent decline in frequency was better described as the sum of two exponential functions: an early phase, lasting < 2 s, and a late phase, which lasted for the duration of the discharge period. 3. The magnitude of initial adaptation was correlated with the initial firing frequency (i.e., the reciprocal of the 1st interspike interval). The magnitudes of the early and late phases of adaptation were correlated with the firing frequency reached at the end of initial adaptation. Neither the magnitudes nor the time courses of the three phases were correlated with other membrane properties such as input resistance, rheobase, or repetitive firing threshold. 4. The slope of the frequency-current (f-I) curve was steeper in the initial phase (first 2-5 spikes) than in either the early (< 2 s) or late (> 2 s) phases of adaptation as previously reported by other investigators. In the absence of early adaptation, a steady state for the f-I slope was reached by 0.7-1 s, the time typically reported in studies of repetitive discharge. However, when early adaptation was present (50% of the trials), a steady-state value for the f-I slope was not reached until the cell had discharged for > 1 s. 5. To characterize the time course of firing rate recovery from the adaptive processes, the current was turned off for periods of < or = 10 s during the course of a 60-s trial.(ABSTRACT TRUNCATED AT 400 WORDS)

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Metadata

Authors
Sawczuk, A., Powers, R. K., & Binder, M. D.
Affiliations
University of Washington (US)
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
1995-05-01
Volume
73
Issue
5
Pages
1799-1810
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.1995.73.5.1799
OpenAlex
W2402388036
Cited by
144
References
45
Citations by year
2026: 6 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 10 · 2013: 3 · 2012: 2
FWCI
1.98
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k08ns001650-05)
  • National Institute of Neurological Disorders and Stroke (NS-26840, R01NS026840, NS 01650)
  • National Institute of Dental and Craniofacial Research (K16DE000161, DE 00161)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
spike frequency adaptation, hypoglossal motoneurons, hypoglossal nucleus, repetitive firing, interspike intervals, input resistance, rheobase
MeSH terms
Animals, Brain Stem, Electrophysiology, Hypoglossal Nerve, Kinetics, Membrane Potentials, Motor Neurons, Neural Conduction, Time Factors, Rats, Sprague-Dawley, Rats

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