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Cited by 715

The DOI matches its Crossref record.

Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys

Nudo, R. J., Milliken, G. W.·1996·Journal of Neurophysiology
DOI 10.1152/jn.1996.75.5.2144
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Abstract

1. Intracortical microstimulation (ICMS) techniques were used to derive detailed maps of distal forelimb movement representations in primary motor cortex (area 4) of adult squirrel monkeys before and a few months after a focal ischemic infarct. 2. Infarcts caused a marked but transient deficit in use of the contralateral hand, as evidenced by increased use of the ipsilateral hand, and reduced performance on a task requiring skilled digit use. 3. Infarcts resulted in a widespread reduction in the areal extent of digit representations adjacent to the lesion, and apparent increases in adjacent proximal representations. 4. We conclude that substantial functional reorganization occurs in primary motor cortex of adult primates following a focal ischemic infarct, but at least in the absence of postinfarct training, the movements formerly represented in the infarcted zone do not reappear in adjacent cortical regions.

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Metadata

Authors
Nudo, R. J., & Milliken, G. W.
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
1996-05-01
Volume
75
Issue
5
Pages
2144-2149
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.1996.75.5.2144
OpenAlex
W2313447995
Cited by
715
References
0
FWCI
6.17
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.