The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Early Locomotor Training With Clonidine in Spinal Cats
Abstract
Clonidine, a noradrenergic alpha-2 agonist, can initiate locomotion early after spinalization in cats. Because this effect lasts 4-6 h, we have injected clonidine daily, intraperitoneally or intrathecally, and intensively trained five spinal cats to perform hindlimb walking on a treadmill starting at day 3 and continuing until 10 days posttransection. Each day, clonidine was injected to induce locomotor activity and cats were trained to walk with as much weight support as possible and at different speeds during multiple (1-5) locomotor training sessions, each lasting from 10 to 20 min, until the effects of clonidine wore off. Electromyographic (EMG) activity synchronized to video images of the hindlimbs were recorded before and after each clonidine injection. The results showed, first, a day-to-day change of the locomotor pattern induced by clonidine from the 3rd to the 11th day including an increase in the duration of the step cycle, an increase in the duration of extensor EMG activity, and an increase in total angular excursion of the hip, knee, and ankle joints. Second, after 6-11 days of this regimen, there was an emergence of a coordinated locomotor pattern with weight support of the hindquarters that was visible even before that day's clonidine injection. The results suggested that daily injection of clonidine followed by early and daily interactive locomotor training can enhance the recovery of locomotion in spinal cats.
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From Effectiveness of Virtual Reality in Children With Cerebral Palsy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2018) · cites this paper as [62]
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Metadata
- Authors
- Chau, C., Barbeau, H., & Rossignol, S.
- Affiliations
- Université de Montréal (CA)
- McGill University (CA)
- ORCID
- Rossignol, Serge
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1998-01-01
- Volume
- 79
- Issue
- 1
- Pages
- 392-409
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2258205771
- Cited by
- 142
- References
- 42
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 6
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- clonidine, spinal cord transection, treadmill training, alpha-2 adrenergic agonists, locomotion patterns, body weight support, electromyography
- MeSH terms
- Animals, Cats, Clonidine, Electromyography, Female, Laminectomy, Locomotion, Male, Motor Activity, Spinal Cord, Time Factors, Muscle, Skeletal
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