Modeling physiological events in 2D vs. 3D cell culture

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15. Impact of culture dimensionality and matrix composition on morphology, phenotype and drug response in pancreatic cancer models
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16. Next-Generation In Vitro Pulmonary Platforms for Respiratory Disease Modelling and Therapeutic Development: Current Advances and Future Prospects
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18. Advancing the 3Rs in bone tissue engineering: emerging in vitro, in silico, and refined in vivo strategies
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19. Automated stem cell-derived organoid platforms for disease modeling
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20. Immune Microphysiological Systems for Human Innate Immunity
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21. Dynamic biomimicry in skin-on-a-chip: multi-scale construction to translational dermatology, drug screening and cosmetic evaluation
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22. Magnetoelectric 3D Microenvironments for Tissue Engineering: A Comprehensive Review
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23. Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation
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24. 3D bioprinting for cancer modeling and drug screening
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25. Modeling Neuroimmunological Interactions at the Blood–Brain Barrier Using In Vitro 3D Human Organoids: Inflammation and Ischemia–Reperfusion Injury
    Aya A. El-Taibany, Kathleen McGovern, Goodwell Nzou, Daniel A. Porada, Michael C. Seeds, Anthony Atala · 2026 · Cells
26. Modeling Catheter‐Associated Bladder Mucosal Adhesion and Microtrauma Using a Human Urothelial Microtissue Model
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27. Development of reduced graphene oxide-incorporated gelatin–polymannose hydrogel scaffolds as a 3D cell culture model for cancer research
    Hema Priya Manivannan, Vishnu Priya Veeraraghavan, Arul Prakash Francis · 2026 · Journal of Biomaterials Science Polymer Edition
28. Dynamic Nutrient Consumption of Cultured Meat in Bioreactors: Metabolomics-Guided Optimization for Enhanced Cell Proliferation and Stemness
    Zixuan Wang, Zhongyuan Wu, M Zhang, Tianyi Tao, Runxi Han, Yunting Xie, Jie Wang, Shijie Ding, Guanghong Zhou, Chong Wang · 2026 · Journal of Agricultural and Food Chemistry
29. Emerging Regenerative Medicine for Spinal Cord Injury: Spinal Cord Organoids-on-a-Chip
    Manzar Khan, Hyunjin Choi, Sareer Ahmad, Somin Lee, Jong‐Chan Park, Inbo Han · 2026 · International Journal of Molecular Sciences
30. A Framework Linking Glycolytic Metabolic Capabilities and Tumor Dynamics
    Eleftheria Tzamali, Georgios Tzedakis, Vangelis Sakkalis · 2019 · IEEE Journal of Biomedical and Health Informatics
31. In Vitro Assays Used to Analyse Vascular Cell Functions
    Adrian Türkcan, David Bernhard, Barbara Meßner · 2019 · Learning materials in biosciences
32. Visualizing and Evaluating Cancer Cell Growth and Invasion by a Novel 3D Culture System
    Chloe Shay, Liwei Lang, Yong Teng · 2020 · Methods in molecular biology
33. Oxidative Stress Monitoring in In Vitro and In Vivo Models
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34. Electrophoretic injection and reaction of dye-bound enzymes to protein and bacteria within gel
    Youji Shimazaki, Aoshi Inoue, Haruka Ikeuchi · 2020 · Journal of Microbiological Methods
35. 3D culture systems as models for solid tumors and cancer metabolism
    Sónia Pires Celeiro, Fátima Baltazar, Marta Viana‐Pereira · 2020 · Elsevier eBooks
36. The effect of anti-inflammatory agents (glucosamine sulphate and aloe vera) on mouse mesenchymal stem cells
    Easwar Kumar Vigneshwari, Nambiar Roshni, Sidhu Karandeep, Tawil Bill · 2020 · Journal of Applied Biotechnology & Bioengineering
37. An Evaluation of the Inhibition Effects of Cell Migration of Aspirin Soaking 360°Square-Edge Intraocular Lens in an in Vitro Lens Capsule Model
    Lian Feiyue, Li Yang, Jiangyue Zhao · 2021 · Current Eye Research
38. Bioreactor design for the mechanical stimulation by compression of 3D cell cultures
    Carina M. Micheler, Paulina A. Geck, Fiona Charitou, René Leix, Peter Foehr, Jan J. Lang, Nikolas Wilhelm, Jutta Tuebel, Rainer Burgkart · 2021 · Current Directions in Biomedical Engineering
39. Advances and applications in liver organoid technology
    Li Lin, Miao LEI, JiaMan LIN, Wenxiang Hu · 2021 · Scientia Sinica Vitae
40. Modification of Single Cells Within Mouse Mammary Gland Derived Acini via Viral Transduction
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41. Experimental and Computational Models of Transport of Galectin-3 Through Glycosylated Matrix
    Janny Piñeiro-Llanes, Camille D. Rodriguez, Shaheen A. Farhadi · 2022 · Annals of Biomedical Engineering
42. Model Organisms and Systems in Life Sciences
    Mert Polat, Feride İffet Şahin, Yunus Kasım Terzi · 2022 · Cumhuriyet Tıp Dergisi/Cumhuriyet Üniversitesi Tıp Fakültesi dergisi
43. Priming strategies for controlling stem cell fate: Applications and challenges in dental tissue regeneration
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44. The design basis and application in urology of the tumor-on-a-chip platform
    Fei Sheng, Ruipeng Jia · 2022 · Urologic Oncology Seminars and Original Investigations
45. Microfluidic and Organ-on-a-chip-based Technologies for Diabetes Therapy and Research
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46. Tissue-engineered anterior segment eye cultures demonstrate hallmarks of conventional organ culture
    Susannah Waxman, Alicja Strzalkowska, Chao Wang, Ralitsa T. Loewen, Yalong Dang, Nils A. Loewen · 2022 · Graefe s Archive for Clinical and Experimental Ophthalmology
47. Cell culture techniques in microfluidic chips
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48. Human neural stem cells in developmental neurotoxicology: Current scenario and future prospects
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49. Adhesion measurement of living cells based on electrical impedance
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50. Impact of 17β-Estradiol on the Shape, Survival, Osteogenic Transformation, and mRNA Expression of Gingiva-Derived Stem Cell Spheroids
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51. Microfluidic Chip Fabrication for Tumor Cell 3D Culture Based on Microwell Arrays
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52. Regenerative Approaches in Gingival Tissue Engineering
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53. Towards a Lab-on-a-Chip as a Service (LoCaaS) Framework for in Vitro Cancer Cell Assays
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54. In Vitro Models of Cardiovascular Disease: Embryoid Bodies, Organoids and Everything in Between
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55. RHO-Associated Coiled-Coil-Containing Protein Kinase Inhibitors Significantly Modulate the Epithelial–Mesenchymal Transition Induced by TGF-β2 in the 2-D and 3-D Cultures of Human Corneal Stroma Fibroblasts
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56. Repopulation of a 3D simulated periapical lesion cavity with dental pulp stem cell spheroids with triggered osteoblastic differentiation
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57. Bioreactor Sytems: Physiology of Cell Cultures
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58. Multi-cell lines culturing system utilizing microfluidic three-dimensional additive manufactured polymeric scaffolds with controlled pumping
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59. Interface morphodynamics in living tissues
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60. Transcriptomic Profile of Human Osteoblast-like Cells Grown on Trabecular Titanium
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61. Injectable, Manganese-Labeled Alginate Hydrogels as a Matrix for Longitudinal and Rapidly Retrievable 3D Cell Culture
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62. Targeting Metastasis: Exploring the Impact of Microbial Infections on Cancer Progression Through Innovative Biological Models
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63. AI-powered image standardization in microphysiological system platforms
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64. Unraveling the Effects of Epigallocatechin-3-gallate on Hepatocellular Carcinoma Cells: A Comparative Analysis of Monolayer vs Multicellular Tumor Spheroids
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65. The Applications and Outlook of Organ-on-a-Chip in Pharmacy and Pharmacology (Review)
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66. Umbilical Cord Mesenchymal Stem Cells as a Meritorious Option to Treat Psoriasis
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67. Glycosaminoglycans Targeted by Colchicine in MCF-7 Cells
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68. An adapted particle swarm optimization algorithm as a model for exploring premyofibril formation
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69. Development of Cellulose Acetate-Based Scaffold for Bone Tissue Engineering Applications
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70. Improving Endothelial Explant Tissue Culture by Novel Thermoresponsive Cell Culture System
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71. The Adequacy of Experimental Models and Understanding the Role of Non-coding RNA in Joint Homeostasis and Disease
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72. Biologia Futura: the importance of 3D organoids—a new approach for research on neurological and rare diseases
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73. In vitro Approaches to Model Breast Tumor Complexity
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74. Characterization of the regulatory 5′-flanking region of bovine mucin 2 (MUC2) gene
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75. Decellularized Matrix Hydrogels for In Vitro Disease Modeling
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76. IPSC-derived intestinal organoids and current 3D intestinal scaffolds
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77. Tissue-Engineered Anterior Segment Eye Cultures Display an Intraocular Pressure Homeostatic Response
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78. A 2-Compartment Bone Tumor Model for Testing the Efficacy of Cancer Drugs
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79. Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca 2+ control in skeletal muscle fibers
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80. Waste-to-wealth : American bullfrog skin-derived collagen for wound dressing applications
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81. In vitro bioengineering applications of melt electrowritten and hydrogel composite scaffolds
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82. Fiber Diameter and Architecture Direct Three-Dimensional Assembly of Pericytes into Spheroids
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83. Jammed microgel growth medium prepared by flash-solidification of agarose for 3D cell culture and 3D bioprinting
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84. Methods for Analyzing the Biological and Biomedical Properties of Biomaterials
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85. Engineering Particle-based Materials for Vasculogenesis
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86. [Research progress on vascularization of organoids].
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87. LIVECell---A large-scale dataset for label-free live cell segmentation
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88. Peptide aggregation-induced immunogenic cell death in a breast cancer spheroid model
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89. A bovine pulmosphere model and multiomics analyses identify a signature of early host response to Mycobacterium tuberculosis infection
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90. Application of 3D Bioprinting Technology Apply to Assessing Dangguiniantongtang (DGNT) Decoctions in Arthritis
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91. Characterizing the viscoelastic properties of different fibroblasts in 2D and 3D collagen gels
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92. Cancer-Associated Fibroblasts induce aggressive stem cell phenotype and chemoresistance in cervical tumoroid-fibroblast co-culture system via upregulating CK17 expression
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93. Sex Differences in Cancer Functional Genomics: Gene Dependency and Drug Sensitivity
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94. Repurposing Romidepsin for Osteosarcoma: Screening FDA-Approved Oncology Drugs with Three-Dimensional Osteosarcoma Spheroids
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95. Alternating 2D and 3D Culture Reduces Cell Size and Extends the Lifespan of Placenta-Derived MSCs
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96. Matrix viscoelasticity regulates dermal fibroblast activation in a three-dimensional fibrillar microenvironment
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97. Development of In-Vitro and In-Vivo Devices to Study the Mechanobiology of Ligament Healing
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98. Convergence of Three-Dimensional Cell Culture and Human iPS Cells: Improving Clinical Relevance in Drug Discovery
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99. Identification of proteomic biomarkers for the prediction of implant biological responses
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100. Embryonic Stem Cells and the Influence of the Microenvironment
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