How Does the Kidney Filter Plasma?

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

Kestilä, M., Lenkkeri, U., Männikkö, M., Lamerdin, J., McCready, P., Putaala, H., Ruotsalainen, V., Morita, T., Nissinen, M., Herva, R., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80057-x · Cited by 1,866 · see citing works

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome

Boute, N., Gribouval, O., Roselli, S., Benessy, F., Lee, H., Fuchshuber, A., Dahan, K., Gubler, M.-C., Niaudet, P., & Antignac, C. (2000) · Nature Genetics · doi:10.1038/74166 · Cited by 1,444 · see citing works

Alport's Syndrome, Goodpasture's Syndrome, and Type IV Collagen

Hudson, B. G., Tryggvason, K., Sundaramoorthy, M., & Neilson, E. G. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022296 · Cited by 960 · see citing works

Identification of Mutations in the COL4A5 Collagen Gene in Alport Syndrome

Barker, D. F., Hostikka, S. L., Zhou, J., et al. (1990) · Science · doi:10.1126/science.2349482 · Cited by 885 · see citing works

Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein

Shih, N., Li, J., Vv, K., Nguyen, A., Dustin, M. L., Kanagawa, O., Miner, J. H., & Shaw, A. S. (1999) · Science · doi:10.1126/science.286.5438.312 · Cited by 854 · see citing works

Nephrin is specifically located at the slit diaphragm of glomerular podocytes

Ruotsalainen, V., Ljungberg, P., Wartiovaara, J., Lenkkeri, U., Kestilä, M., Jalanko, H., Holmberg, C., & Tryggvason, K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7962 · Cited by 766 · see citing works

Isolation of a heparan sulfate-containing proteoglycan from basement membrane.

Hassell, J. R., Robey, P. G., Barrach, H.-J., Wilczek, J., Rennard, S. I., & Martin, G. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.8.4494 · Cited by 674 · see citing works

The Laminin α Chains: Expression, Developmental Transitions, and Chromosomal Locations of α1-5, Identification of Heterotrimeric Laminins 8–11, and Cloning of a Novel α3 Isoform

Miner, J. H., Patton, B. L., Lentz, S. I., Gilbert, D. J., Snider, W. D., Jenkins, N. A., Copeland, N. G., & Sanes, J. R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.3.685 · Cited by 650 · see citing works

Increased permeability of the glomerular basement membrane to ferritin after removal of glycosaminoglycans (heparan sulfate) by enzyme digestion.

Kanwar, Y. S., Linker, A., & Farquhar, M. G. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.86.2.688 · Cited by 649 · see citing works

Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis.

Hudson, B. G., Reeders, S. T., & Tryggvason, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74270-7 · Cited by 618 · see citing works

POROUS SUBSTRUCTURE OF THE GLOMERULAR SLIT DIAPHRAGM IN THE RAT AND MOUSE

Rodewald, R., & Karnovsky, M. J. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.60.2.423 · Cited by 585 · see citing works

Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin

Schwarz, K., Simons, M., Reiser, J., Saleem, M. A., Faul, C., Kriz, W., Shaw, A. S., Holzman, L. B., & Mundel, P. H. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12849 · Cited by 558 · see citing works

Anionic sites in the glomerular basement membrane. In vivo and in vitro localization to the laminae rarae by cationic probes.

Kanwar, Y. S., & Farquhar, M. G. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.81.1.137 · Cited by 554 · see citing works

The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death

Putaala, H. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.1.1 · Cited by 541 · see citing works

Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin

Schwarz, K., Simons, M., Reiser, J., Saleem, M. A., Faul, C., Kriz, W., Shaw, A. S., Holzman, L. B., & Mundel, P. H. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112849 · Cited by 508 · see citing works

The Glomerular Slit Diaphragm Is a Modified Adherens Junction

Reiser, J., Kriz, W., Kretzler, M., & Mundel, P. H. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1111 · Cited by 464 · see citing works

Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRIN

Donoviel, D. B., Freed, D. D., Vogel, H. S., Potter, D., Hawkins, E. P., Barrish, J. P., Mathur, B. N., Turner, C. A., Geske, R. S., Montgomery, C. A., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4829-4836.2001 · Cited by 439 · see citing works

Permeation of the luminal capillary glycocalyx is determined by hyaluronan

Henry, C. B. S., & Duling, B. R. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h508 · Cited by 426 · see citing works

The renal glomerulus of mice lacking s–laminin/laminin β2: nephrosis despite molecular compensation by laminin β1

Noakes, P. G., Miner, J. H., Gautam, M., et al. (1995) · Nature Genetics · doi:10.1038/ng0895-400 · Cited by 424 · see citing works

Role of molecular charge in glomerular permeability. Tracer studies with cationized ferritins.

Rennke, H. G., Cotran, R. S., & Venkatachalam, M. A. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.67.3.638 · Cited by 412 · see citing works

Interaction with Podocin Facilitates Nephrin Signaling

Huber, T. B., Köttgen, M., Schilling, B., Walz, G., & Benzing, T. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100452200 · Cited by 378 · see citing works

The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium.

Schnabel, E., Anderson, J. M., & Farquhar, M. G. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.3.1255 · Cited by 341 · see citing works

Basal lamina assembly

Yurchenco, P. D., & O’Rear, J. J. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90093-0 · Cited by 319 · see citing works

Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

Wartiovaara, J., Öfverstedt, L., Khoshnoodi, J., Zhang, J., Mäkelä, E., Sandin, S., Ruotsalainen, V., Cheng, R. H., Jalanko, H., Skoglund, U., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22562 · Cited by 318 · see citing works

Unraveling the Mechanisms of Glomerular Ultrafiltration

Tryggvason, K. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v10112440 · Cited by 287 · see citing works

Precocious Mammary Gland Development in P-Cadherin–deficient Mice

Radice, G., Ferreira-Cornwell, M., Robinson, S., Rayburn, H., Chodosh, L., Takeichi, M., & Hynes, R. (1997) · Journal of Cell Biology · doi:10.1083/jcb.139.4.1025 · Cited by 286 · see citing works

Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype

Ciani, L., Patel, A., Allen, N. D., & ffrench‐Constant, C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.10.3575-3582.2003 · Cited by 255 · see citing works

NEPH1 defines a novel family of podocin‐interacting proteins

Sellin, L. K., Huber, T. B., Gerke, P., Quack, I., Pavenstädt, H., & Walz, G. (2002) · The FASEB Journal · doi:10.1096/fj.02-0242fje · Cited by 252 · see citing works

Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability

Liu, G., Kaw, B., Kurfis, J., Rahmanuddin, S., Kanwar, Y. S., & Chugh, S. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18242 · Cited by 241 · see citing works

Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney

Rossi, M., Morita, H., Sormunen, R., Airenne, S., Kreivi, M., Wang, L., Fukai, N., Olsen, B. R., Tryggvason, K., & Soininen, R. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg019 · Cited by 237 · see citing works

FAT is a component of glomerular slit diaphragms

Inoue, T., Yaoita, E., Kurihara, H., Shimizu, F., Sakai, T., Kobayashi, T., Ohshiro, K., Kawachi, H., Okada, H., Suzuki, H., et al. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590031003.x · Cited by 229 · see citing works

Homodimerization and Heterodimerization of the Glomerular Podocyte Proteins Nephrin and NEPH1

Gerke, P., Huber, T. B., Sellin, L. K., Benzing, T. R., & Walz, G. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000057853.05686.89 · Cited by 204 · see citing works

Heparan Sulfate–Rich Anionic Sites in the Human Glomerular Basement Membrane

Vernier, R. L., Klein, D. J., Sisson, S. P., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198310273091701 · Cited by 204 · see citing works

Distribution of annionic sites in glomerular basement membranes: their possible role in filtration and attachment.

CAULFIELD, J. P., & Farquhar, M. G. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.5.1646 · Cited by 193 · see citing works

Glomerular permeability: In vivo tracer studies with polyanionic and polycationic ferritins

Rennke, H. G., & Venkatachalam, M. A. (1977) · Kidney International · doi:10.1038/ki.1977.6 · Cited by 187 · see citing works

Agrin Is a Major Heparan Sulfate Proteoglycan in the Human Glomerular Basement Membrane

Groffen, A. J. A., Rüegg, M. A., Dijkman, H. B. P. M., et al. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804600104 · Cited by 183 · see citing works

Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability

Liu, G., Kaw, B., Kurfis, J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318242 · Cited by 181 · see citing works

Structure and Flexibility of Individual Immunoglobulin G Molecules in Solution

Sandin, S., Öfverstedt, L., Wikström, A., Wränge, Ö., & Skoglund, U. (2004) · Structure · doi:10.1016/j.str.2004.02.011 · Cited by 171 · see citing works

Current status of the structural and functional basis of glomerular filtration and proteinuria.

Kanwar, Y. S., Liu, Z. Z., Kashihara, N., et al. (1991) · PubMed · Cited by 162 · see citing works

Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function

Smithies, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730776100 · Cited by 160 · see citing works

Nephrin Promotes Cell-Cell Adhesion through Homophilic Interactions

Khoshnoodi, J., Sigmundsson, K., Öfverstedt, L., Skoglund, U., Öbrink, B., Wartiovaara, J., & Tryggvason, K. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63590-0 · Cited by 147 · see citing works

The Carboxyl Terminus of Neph Family Members Binds to the PDZ Domain Protein Zonula Occludens-1

Huber, T. B., Schmidts, M., Gerke, P., Schermer, B., Zahn, A., Hartleben, B., Sellin, L. K., Walz, G., & Benzing, T. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200678200 · Cited by 133 · see citing works

Why Do We Not All Have Proteinuria? An Update of Our Current Understanding of the Glomerular Barrier

Haraldsson, B. S., & Sörensson, J. (2004) · Physiology · doi:10.1152/nips.01461.2003 · Cited by 122 · see citing works

Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane

Groffen, A. J. A., Veerkamp, J. H., Monnens, L. A. H., et al. (1999) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/14.9.2119 · Cited by 98 · see citing works

The structural basis of glomerular filtration.

Mj, K., & Sk, A. (1972) · PubMed · Cited by 92 · see citing works

Abnormal protein traffic through the glomerular barrier induces proximal tubular cell dysfunction and causes renal injury

Remuzzi, G. (1995) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-199507000-00009 · Cited by 81 · see citing works

Glomerular charge selectivity for horseradish peroxidase and albumin at low and normal ionic strengths

Sörensson, J., Ohlson, M., Lindström, K., et al. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.00315.x · Cited by 52 · see citing works

Three-dimensional study of glomerular slit diaphragm by the quick-freezing and deep-etching replica method.

Hora, K., Ohno, S., Oguchi, H., et al. (1990) · PubMed · Cited by 35 · see citing works

Glomerular Endothelial Glycocalyx

Avasthi, P. S., & Koshy, V. (2015) · Contributions to nephrology · doi:10.1159/000416500 · Cited by 19 · see citing works

Measuring biological age using omics data

Rutledge, J., Oh, H., & Wyss-Coray, T. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00511-7 · Cited by 570 · see citing works

A Slit in Podocyte Death

Moreno, J. A., Sánchez-Niño, M. D., Sanz, A. B., et al. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708784911542 · Cited by 21 · see citing works

Loss of Podocyte aPKCλ/ι Causes Polarity Defects and Nephrotic Syndrome

Huber, T. B., Hartleben, B. D., Winkelmann, K., Schneider, L., Becker, J. U., Leitges, M., Walz, G., Haller, H., & Schiffer, M. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008080871 · Cited by 100 · see citing works

Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach

Yu, S. M.-W., Nissaisorakarn, P., Husain, I., & Jim, B. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00221 · Cited by 86 · see citing works

Faculty Opinions recommendation of Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome.

Reiser, J. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1159454.619820

Nephrinuria and podocytopathies

Kostovska, I., Trajkovska, K. T., Topuzovska, S., Cekovska, S., Labudović, D. D., Костовски, О., & Spasovski, G. B. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2021.08.001 · Cited by 18 · see citing works