S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages

Functions of DNA methylation: islands, start sites, gene bodies and beyond

Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061 · see citing works

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882 · see citing works

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182 · see citing works

HMDB 3.0—The Human Metabolome Database in 2013

Wishart, D. S., Jewison, T., Guo, A. C., Wilson, M., Knox, C., Liu, Y., Djoumbou-Feunang, Y., Mandal, R., Aziat, F., Dong, E., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1065 · Cited by 2,845 · see citing works

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245 · see citing works

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

Irizarry, R. A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.298 · Cited by 2,177 · see citing works

Inflammation in osteoarthritis

Goldring, M. B., & Otero, M. (2011) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328349c2b1 · Cited by 1,462 · see citing works

Atherosclerosis is an inflammatory disease

Ross, R. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70266-8 · Cited by 1,458 · see citing works

Diabetes Mellitus and Inflammation

Lontchi‐Yimagou, E., Sobngwi, E., Matsha, T. E., & Kengne, A. P. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0375-y · Cited by 814 · see citing works

Rethinking how DNA methylation patterns are maintained

Jones, P. A., & Liang, G. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2651 · Cited by 767 · see citing works

CCL2/Monocyte Chemoattractant Protein-1 Regulates Inflammatory Responses Critical to Healing Myocardial Infarcts

Dewald, O., Zymek, P. T., Winkelmann, K., Koerting, A., Ren, G., Abou-Khamis, T., Michael, L. H., Rollins, B. J., Entman, M. L., & Frangogiannis, N. G. (2005) · Circulation Research · doi:10.1161/01.res.0000163017.13772.3a · Cited by 721 · see citing works

The DNA methylation paradox

Jones, P. A. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(98)01636-9 · Cited by 665 · see citing works

Increased Homocysteine and S-Adenosylhomocysteine Concentrations and DNA Hypomethylation in Vascular Disease

Castro, R., Rivera, I. A., Struys, E. A., Jansen, E. E. W., Ravasco, P., Camilo, M., Blom, H. J., Jakobs, C., & de Almeida, I. T. (2003) · Clinical Chemistry · doi:10.1373/49.8.1292 · Cited by 409 · see citing works

Cytokines and Glucocorticoid Receptor Signaling

Pace, T. W. W., & Miller, A. H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04984.x · Cited by 339 · see citing works

Intracellular S-Adenosylhomocysteine Concentrations Predict Global DNA Hypomethylation in Tissues of Methyl-Deficient Cystathionine β-Synthase Heterozygous Mice

Caudill, M. A., Wang, J. C., Melnyk, S., Pogribny, I. P., Collins, M. D., Santos‐Guzmán, J., Swendseid, M. E., Cogger, E. A., James, S. J., & Jernigan, S. (2001) · Journal of Nutrition · doi:10.1093/jn/131.11.2811 · Cited by 336 · see citing works

Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes.

Ziegler-Heitbrock, H. W. L., Sternsdorf, T., Liese, J. G., Belohradsky, B. H., Weber, C., Wedel, A., Schreck, R., Baeuerle, P. A., & Ströbel, M. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.12.6986 · Cited by 302 · see citing works

<i>S</i> -Adenosyl Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind, Randomized Clinical Trial

Papakostas, G. I., Mischoulon, D., Shyu, I., Alpert, J. E., & Fava, M. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09081198 · Cited by 297 · see citing works

Cytokines and Alcoholic Liver Disease

McClain, C. J., Hill, D. B., Schmidt, J., & Diehl, A. M. (1993) · Seminars in Liver Disease · doi:10.1055/s-2007-1007347 · Cited by 279 · see citing works

A Method to Assess Genomic DNA Methylation Using High-Performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry

Friso, S., Choi, S., Dolnikowski, G. G., & Selhub, J. (2002) · Analytical Chemistry · doi:10.1021/ac020050h · Cited by 225 · see citing works

Monocyte Chemoattractant Protein-1 Induces Proliferation and Interleukin-6 Production in Human Smooth Muscle Cells by Differential Activation of Nuclear Factor-κB and Activator Protein-1

Viedt, C., Vogel, J., Athanasiou, T., Shen, W., Orth, S. R., Kübler, W., & Kreuzer, J. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000019009.73586.7f · Cited by 192 · see citing works

Epigenetics in Adipose Tissue, Obesity, Weight Loss, and Diabetes

Martínez, J. A., Milagro, F. I., Claycombe, K., & Schalinske, K. L. (2014) · Advances in Nutrition · doi:10.3945/an.113.004705 · Cited by 182 · see citing works

Critical Role for Monocyte Chemoattractant Protein-1 and Macrophage Inflammatory Protein-1α in Induction of Experimental Autoimmune Myocarditis and Effective Anti–Monocyte Chemoattractant Protein-1 Gene Therapy

Göser, S., Öttl, R., Brodner, A., Dengler, T. J., Torzewski, J., Egashira, K., Rose, N. R., Katus, H. A., & Kaya, Z. (2005) · Circulation · doi:10.1161/circulationaha.105.572396 · Cited by 152 · see citing works

S-Adenosylmethionine attenuates the lipopolysaccharide-induced expression of the gene for tumour necrosis factor α

Watson, W. H., Zhao, Y., & Chawla, R. K. (1999) · Biochemical Journal · doi:10.1042/bj3420021 · Cited by 124 · see citing works

Determination of S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma and Cerebrospinal Fluid by Stable-Isotope Dilution Tandem Mass Spectrometry

Struys, E. A., Jansen, E. E. W., de Meer, K., & Jakobs, C. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.10.1650 · Cited by 124 · see citing works

S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation

Iglesias–Ara, A., Xia, M., Ramani, K., Mato, J. M., & Lu, S. C.-L. (2008) · Hepatology · doi:10.1002/hep.22231 · Cited by 114 · see citing works

Nuclear Factor-κB Activation by the CXC Chemokine Melanoma Growth-stimulatory Activity/Growth-regulated Protein Involves the MEKK1/p38 Mitogen-activated Protein Kinase Pathway

Wang, D., & Richmond, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006115200 · Cited by 93 · see citing works

Osteopontin Is an Activator of Human Adipose Tissue Macrophages and Directly Affects Adipocyte Function

Zeyda, M., Gollinger, K., Todoric, J., Kiefer, F. W., Keck, M. K., Aszmann, O. C., Prager, G., Zlabinger, G. J., Petzelbauer, P., & Stulnig, T. M. (2011) · Endocrinology · doi:10.1210/en.2010-1328 · Cited by 85 · see citing works

S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease.

Hardy, M. L., Coulter, I., Morton, S. C., Favreau, J. T., Venuturupalli, S. R., Chiappelli, F., Rossi, F., Orshansky, G., Jungvig, L., Roth, E., et al. (2003) · PubMed Central · Cited by 81 · see citing works

S-Adenosylmethionine, cytokines, and alcoholic liver disease

McClain, C. J., Hill, D. B., Song, Z., Chawla, R. K., Watson, W. H., Chen, T., & Barve, S. S. (2002) · Alcohol · doi:10.1016/s0741-8329(02)00224-0 · Cited by 80 · see citing works

Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart

D’Souza, A., Hussain, M., Howarth, F. C., Woods, N. M., Bidasee, K. R., & Singh, J. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0148-8 · Cited by 75 · see citing works

Accurate genome-scale percentage DNA methylation estimates from microarray data

Aryee, M. J., Wu, Z. J., Ladd‐Acosta, C., Herb, B. R., Feinberg, A. P., Yegnasubramanian, S., & Irizarry, R. A. (2010) · Biostatistics · doi:10.1093/biostatistics/kxq055 · Cited by 71 · see citing works

A Gene Expression Signature That Classifies Human Atherosclerotic Plaque by Relative Inflammation Status

Puig, Ó., Yuan, J., Stepaniants, S. B., Zieba, R., Zycband, E., Morris, M. D., Coulter, S., Yu, X., Menke, J. G., Woods, J., et al. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.960773 · Cited by 64 · see citing works

Transcriptional impact of dietary methionine restriction on systemic inflammation: Relevance to biomarkers of metabolic disease during aging

Wanders, D., Ghosh, S., Stone, K. P., Van, N. T., & Gettys, T. W. (2013) · BioFactors · doi:10.1002/biof.1111 · Cited by 60 · see citing works

S-adenosylmethionine (SAMe) modulates interleukin-10 and interleukin-6, but not TNF, production via the adenosine (A2) receptor

Song, Z., Uriarte, S. M., Sahoo, R., Chen, T., Barve, S. S., Hill, D. B., & McClain, C. J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.12.001 · Cited by 58 · see citing works

Uncovering the DNA methylome in chronic lymphocytic leukemia

Cahill, N., & Rosenquist, R. (2013) · Epigenetics · doi:10.4161/epi.23439 · Cited by 52 · see citing works

S-adenosylmethionine modifies cocaine-induced DNA methylation and increases locomotor sensitization in mice

Anier, K., Zharkovsky, A., & Kalda, A. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000394 · Cited by 52 · see citing works

S-Adenosylmethionine Decreases Lipopolysaccharide-Induced Phosphodiesterase 4B2 and Attenuates Tumor Necrosis Factor Expression via cAMP/Protein Kinase A Pathway

Gobejishvili, L., Avila, D. V., Barker, D. F., Ghare, S. S., Henderson, D., Brock, G. N., Kirpich, I., Joshi‐Barve, S., Mokshagundam, S. P., McClain, C. J., et al. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.174268 · Cited by 44 · see citing works

CC chemokine receptor 2 regulates leukocyte recruitment and IL‐10 production during acute polymicrobial sepsis

Feterowski, C., Mack, M., Weighardt, H., Bartsch, B., Kaiser‐Moore, S., & Holzmann, B. (2004) · European Journal of Immunology · doi:10.1002/eji.200425294 · Cited by 43 · see citing works

Monocyte Chemoattractant Protein-1 Secreted by Decidual Stromal Cells Inhibits NK Cells Cytotoxicity by Up-Regulating Expression of SOCS3

Xu, X., Wang, Q., Deng, B., Wang, H., Dong, Z., Qu, X., & Kong, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041869 · Cited by 40 · see citing works

S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes

Song, Z., Barve, S. S., Chen, T., Nelson, W., Uriarte, S. M., Hill, D. B., & McClain, C. J. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00426.2002 · Cited by 37 · see citing works

Emerging anti-inflammatory drugs for atherosclerosis

Berman, J. P., Farkouh, M. E., & Rosenson, R. S. (2013) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2013.801453 · Cited by 35 · see citing works

The effect of 17β-estradiol on cholesterol content in human macrophages is influenced by the lipoprotein milieu

Corcoran, M. P., Lichtenstein, A. H., Meydani, M., Dillard, A. C., Schaefer, E. J., & Lamon‐Fava, S. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-10-0158 · Cited by 32 · see citing works

Comprehensive High‐Throughput Arrays for Relative Methylation (CHARM)

Ladd‐Acosta, C., Aryee, M. J., Ordway, J. M., & Feinberg, A. P. (2010) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg2001s65 · Cited by 32 · see citing works

An initial case of suppressed restenosis with nuclear factor‐kappa B decoy transfection after percutaneous coronary intervention

Suzuki, J., Tezuka, D., Morishita, R., & Isobe, M. (2008) · The Journal of Gene Medicine · doi:10.1002/jgm.1266 · Cited by 28 · see citing works

Hyperhomocysteinemia and Mortality after Coronary Artery Bypass Grafting

Girelli, D., Martinelli, N., Olivieri, O., Pizzolo, F., Friso, S., Faccini, G., Bozzini, C., Tenuti, I., Lotto, V., Villa, G., et al. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000083 · Cited by 20 · see citing works

Tissue-specific relationship of S-adenosylhomocysteine with allele-specificH19/Igf2methylation and imprinting in mice with hyperhomocysteinemia

Glier, M. B., Ngai, Y. F., Sulistyoningrum, D. C., Aleliunas, R. E., Bottiglieri, T., & Devlin, A. M. (2012) · Epigenetics · doi:10.4161/epi.23063 · Cited by 13 · see citing works

42 EFFECT OF S-ADENOSYLHOMOCYSTEINE, A NON-TOXIC EPIGENETIC MODIFYING REAGENT, ON PORCINE FEMALE DONOR CELLS AND CLONED EMBRYOS

Kang, J. T., Choi, J., Park, S., Kim, S., Moon, J. H., Jang, G., & Lee, B. C. (2012) · Reproduction Fertility and Development · doi:10.1071/rdv25n1ab42 · Cited by 1 · see citing works

Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses

Sarris, J., Murphy, J., Mischoulon, D., Papakostas, G. I., Fava, M., Berk, M., & Ng, C. H. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15091228 · Cited by 436 · see citing works

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works

Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial

Chen, H., Liu, S., Ji, L., Wu, T., Ji, Y., Zhou, Y., Zheng, M., Zhang, M., Xu, W., & Huang, G. (2016) · Mediators of Inflammation · doi:10.1155/2016/5912146 · Cited by 202 · see citing works

S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life

Gao, J., Cahill, C. M., Huang, X., Roffman, J. L., Lamon‐Fava, S., D, M. F. M., Mischoulon, D., & Rogers, J. T. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0593-0 · Cited by 138 · see citing works

The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress

Bear, T., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2021) · Microorganisms · doi:10.3390/microorganisms9040723 · Cited by 132 · see citing works

Fatigue in chronic liver disease: New insights and therapeutic approaches

Swain, M. G., & Jones, D. E. (2018) · Liver International · doi:10.1111/liv.13919 · Cited by 125 · see citing works

Crosstalk between metabolism and epigenetics during macrophage polarization

Zhang, K., & Jagannath, C. (2025) · Epigenetics & Chromatin · doi:10.1186/s13072-025-00575-9 · Cited by 128 · see citing works

Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step

Weiskirchen, R. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00303 · Cited by 112 · see citing works

Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice

Ejaz, A., Martínez-Guinó, L., Goldfine, A. B., Ribas‐Aulinas, F., Nigris, V. D., Ribó, S., González-Franquesa, A., García-Rovés, P. M., Li, E., Dreyfuss, J. M., et al. (2016) · Diabetes · doi:10.2337/db15-1094 · Cited by 109 · see citing works

Differences between live and heat-killed bifidobacteria in the regulation of immune function and the intestinal environment.

Sugahara, H., Yao, R., Odamaki, T., & Xiao, J.-Z. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0158 · Cited by 83 · see citing works

Exploring the Role of ATP-Citrate Lyase in the Immune System

Dominguez, M., Brüne, B., & Namgaladze, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632526 · Cited by 75 · see citing works

DNA methylation: A new regulator of phenolic acids biosynthesis in Salvia miltiorrhiza

Yang, D., Huang, Z., Jin, W., Xia, P., Jia, Q., Yang, Z., Hou, Z., Zhang, H., Ji, W., & Han, R. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.07.046 · Cited by 57 · see citing works

Bacterial Lipopolysaccharide Induced Alterations of Genome-Wide DNA Methylation and Promoter Methylation of Lactation-Related Genes in Bovine Mammary Epithelial Cells

Chen, J., Wu, Y., Sun, Y., Dong, X., Wang, Z., Zhang, Z., Xiao, Y., & Dong, G. (2019) · Toxins · doi:10.3390/toxins11050298 · Cited by 48 · see citing works

Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis

Luo, F., Le, N., Mills, T., Chen, N., Karmouty‐Quintana, H., Molina, J. G., Davies, J., Philip, K., Volcik, K. A., Liu, H., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-274845 · Cited by 47 · see citing works

Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism

Mehrmohamadi, M., Mentch, L., Clark, A. G., & Locasale, J. W. (2016) · Nature Communications · doi:10.1038/ncomms13666 · Cited by 45 · see citing works

The Efficacy of S-Adenosyl Methionine and Probiotic Supplementation on Depression: A Synergistic Approach

Ullah, H., Khan, A., Rengasamy, K. R. R., Minno, A. D., Sacchi, R., & Daglia, M. (2022) · Nutrients · doi:10.3390/nu14132751 · Cited by 44 · see citing works

Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer’s disease

Agostini, A., Ding, Y., Bai, L., Kendall, D. A., & Pardon, M. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.019 · Cited by 41 · see citing works

Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review

Noureddin, M., Sander‐Struckmeier, S., & Mato, J. M. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i2.46 · Cited by 39 · see citing works

Acetyl Coenzyme A Synthase 2 Acts as a Prognostic Biomarker Associated with Immune Infiltration in Cervical Squamous Cell Carcinoma

Li, C., Chiu, Y., Chang, C., Chang, Y. I., Sheu, J. J., & Chiang, A. (2021) · Cancers · doi:10.3390/cancers13133125 · Cited by 39 · see citing works

Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells

Lü, J., Liang, Y., Meng, H., Zhang, A., Zhao, J., & Zhang, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.728783 · Cited by 34 · see citing works

One-carbon metabolism markers are associated with cardiometabolic risk factors

Lind, M. V., Lauritzen, L., Vestergaard, H., Hansen, T. F., Pedersen, O. B., Kristensen, M., & Ross, A. B. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.01.005 · Cited by 35 · see citing works

Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation

de Queiroz, K. B., Cavalcante‐Silva, V., Lopes, F. L., Rocha, G. A., D’Almeida, V., & Coimbra, R. S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01763-y · Cited by 35 · see citing works

Targeting Immunity in End-Stage Renal Disease

Baragetti, I., Essawy, B. E., & Fiorina, P. (2017) · American Journal of Nephrology · doi:10.1159/000458768 · Cited by 30 · see citing works

The Role of DNA Methylation in Ischemic Stroke: A Systematic Review

Zeng, M., Zhen, J., Zheng, X.-Q., Qiu, H., Xu, X.-N., Wu, J., Lin, Z., & Hu, J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.566124 · Cited by 24 · see citing works

Neuronutritional Approach to Fibromyalgia Management: A Narrative Review

Badaeva, A. V., Danilov, A. B., Kosareva, A., Lepshina, M., Novikov, V. N., Vorobyeva, Y. D., & Ab, D. (2024) · Pain and Therapy · doi:10.1007/s40122-024-00641-2 · Cited by 29 · see citing works

S‐Adenosyl Methionine in the Therapy of Depression and Other Psychiatric Disorders

Kuželički, N. K. (2016) · Drug Development Research · doi:10.1002/ddr.21345 · Cited by 29 · see citing works

l-Arginine-Dependent Epigenetic Regulation of Interleukin-10, but Not Transforming Growth Factor-β, Production by Neonatal Regulatory T Lymphocytes

Yu, H., Tsai, C., Chang, L., Huang, H.-C., Cheng, H.-H., Wang, J., Sheen, J., Kuo, H., Hsieh, K., Huang, Y., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00487 · Cited by 29 · see citing works

Epigenetic regulation of inflammatory factors in adipose tissue

Jung, B. C., & Kang, S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159019 · Cited by 28 · see citing works

Deciphering DNA Methylation in HIV Infection

Arumugam, T., Ramphal, U., Adimulam, T., Chinniah, R., & Ramsuran, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.795121 · Cited by 28 · see citing works

Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation

Zhao, Q., Hou, J., Chen, B., Shao, X., Zhu, R., Bu, Q., Gu, H., Li, Y., Zhang, B., Du, C., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.05.014 · Cited by 28 · see citing works

Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases

Smolen, P. D., Dash, P. K., & Redell, J. B. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1259405 · Cited by 27 · see citing works

Epigenetic Alterations Induced by Bacterial Lipopolysaccharides

Chiariotti, L., Coretti, L., Pero, R., & Lembo, F. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-24738-0_5 · Cited by 26 · see citing works

HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages

Gupta, K. D., Ramnath, D., von Pein, J. B., Curson, J. E. B., Wang, Y., Abrol, R., Kakkanat, A., Moradi, S. V., Gunther, K. S., Murthy, A. M. V., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212813120 · Cited by 25 · see citing works

Role of lncRNAs as prognostic markers of hepatic cancer and potential therapeutic targeting by S-adenosylmethionine via inhibiting PI3K/Akt signaling pathways

Sadek, K. M., Lebda, M. A., Nasr, N. E., Nasr, S. M., & El-Sayed, Y. S. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-2179-8 · Cited by 24 · see citing works

Association between plasma S-adenosylmethionine and risk of mortality in patients with coronary artery disease: A cohort study

Liu, S., Liao, R., Dai, X., Guo, H., Wang, D., Xia, M., Ling, W., & Xiao, Y. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab210 · Cited by 24 · see citing works

DNA Methylation as A Marker of Response in Rheumatoid Arthritis

Nair, N., Wilson, A. G., & Barton, A. C. (2017) · Pharmacogenomics · doi:10.2217/pgs-2016-0195 · Cited by 24 · see citing works

Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study

Tang, Y., Chen, X., Chen, Q., Xiao, J., Mi, J., Liu, Q., You, Y., Chen, Y., & Ling, W. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00647-7 · Cited by 20 · see citing works

Homocysteine inhibits endothelial progenitor cells proliferation via DNMT1-mediated hypomethylation of Cyclin A

Zhang, H.-P., Wang, Y., Ma, S., Zhang, H., Yang, A., Yang, X., Zhang, M.-H., Sun, J., Hao, Y., & Jiang, Y. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.11.021 · Cited by 20 · see citing works

Ademethionine in the treatment of fatigue in liver diseases: a systematic review

Raikhelson, K. L., & Александровна, К. Э. (2019) · Terapevticheskii arkhiv · doi:10.26442/00403660.2019.02.000130 · Cited by 20 · see citing works

The evolving pathophysiology of TBI and the advantages of temporally-guided combination therapies

Zima, L. A., Moore, A. N., Smolen, P. D., Kobori, N., Noble, B., Robinson, D., Hood, K. N., Homma, R., Mamun, A. A., Redell, J. B., et al. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105874 · Cited by 21 · see citing works

Mycobacterium avium Subsp. hominissuis Interactions with Macrophage Killing Mechanisms

Abukhalid, N. F., Islam, S., Ndzeidze, R., & Bermudez, L. E. (2021) · Pathogens · doi:10.3390/pathogens10111365 · Cited by 21 · see citing works

Hyperhomocysteinemia: Metabolic Role and Animal Studies with a Focus on Cognitive Performance and Decline—A Review

Nieraad, H., Pannwitz, N., de Bruin, N. M. W. J., Geißlinger, G., & Till, U. (2021) · Biomolecules · doi:10.3390/biom11101546 · Cited by 20 · see citing works

Treatment with S-adenosylmethionine ameliorates irinotecan-induced intestinal barrier dysfunction and intestinal microbial disorder in mice

Xiao, L., Dou, W., Wang, Y., Deng, H., Xu, H., & Pan, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115752 · Cited by 18 · see citing works

Integrating Lipidomics, Metabolomics, and Network Pharmacology to Reveal the Mechanism of Cannabidiol against Inflammation in High-Fat, High-Cholesterol Diet-Induced Mice

He, M., Shi, J., Wu, C., Xu, Y., & Liu, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c04994 · Cited by 18 · see citing works

An augmentation study of MSI-195 (S-adenosylmethionine) in Major Depressive Disorder

Targum, S. D., Cameron, B. R., Ferreira, L., & MacDonald, I. D. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.10.010 · Cited by 18 · see citing works

Lipopolysaccharide-induced innate immune responses are exacerbated by Prohibitin 1 deficiency and mitigated by S-adenosylmethionine in murine macrophages

Jung, S., Park, J., & Ko, K. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241224 · Cited by 16 · see citing works

Homocysteine supplementation ameliorates steatohepatitis induced by a choline‐deficient diet in mice

Minami, S., Miura, K., Ishioka, M., Morimoto, N., Isoda, N., Yamamoto, H., & Iijima, K. (2018) · Hepatology Research · doi:10.1111/hepr.13234 · Cited by 16 · see citing works

Current Evidence on the Role of Epigenetic Mechanisms in Migraine: The Way Forward to Precision Medicine

Gazerani, P. (2018) · OBM Genetics · doi:10.21926/obm.genet.1804040 · Cited by 15 · see citing works

Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses

Sarris, J. J., Murphy, J., Mischoulon, D., Papakostas, G. I., D, M. F. M., Berk, M., & Ng, C. H. (2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.16304 · Cited by 13 · see citing works

S‐adenosyl methionine improves motor co‐ordination with reduced oxidative stress, dopaminergic neuronal loss, and DNA methylation in the brain striatum of 6‐hydroxydopamine‐induced neurodegeneration in rats

Jalgaonkar, S. V., Gajbhiye, S. V., Sayyed, M., Tripathi, R. K., Khatri, N., Parmar, U. I., & Shankar, A. (2022) · The Anatomical Record · doi:10.1002/ar.24948 · Cited by 12 · see citing works

How Diverse Are the Protein-Bound Conformations of Small-Molecule Drugs and Cofactors?

Friedrich, N., Simsir, M., & Kirchmair, J. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00068 · Cited by 12 · see citing works

S-adenosyl-l-methionine (SAMe), cannabidiol (CBD), and kratom in psychiatric disorders: Clinical and mechanistic considerations

Levine, M., Gao, J., Satyanarayanan, S. K., Berman, S., Rogers, J. T., & Mischoulon, D. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.013 · Cited by 12 · see citing works

Effects of Sodium Selenite Injection on Serum Metabolic Profiles in Women Diagnosed with Breast Cancer-Related Lymphedema—Secondary Analysis of a Randomized Placebo-Controlled Trial Using Global Metabolomics

Lee, S., Lee, B., Kim, Y.-H., Min, S., Yang, E. J., & Lee, S.-M. (2021) · Nutrients · doi:10.3390/nu13093253 · Cited by 11 · see citing works

Hidradenitis Suppurativa and Five Key Vitamins and Minerals

Weir, S. A., Roman, B., Jiminez, V. S., Burns, M., Sanyi, A. A., Elewski, B. E., & Mayo, T. T. (2023) · Skin Appendage Disorders · doi:10.1159/000528122 · Cited by 10 · see citing works

Epigenetic modulation of glycoprotein VI gene expression by DNA methylation

Gao, S., Han, Y., Chen, X., Dai, L., Gao, H., Lei, Z., Xinzhou, W., Wang, Z., & Wu, H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117103 · Cited by 10 · see citing works

Integration of Metabolomic and Transcriptomic Provides Insights into Anti-Inflammatory Response to trans-10-Hydroxy-2-decenoic Acid on LPS-Stimulated RAW 264.7 Cells

Huang, M., Dong, J., Tan, X., Yang, S., Xiao, M., & Wang, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612666 · Cited by 9 · see citing works

Metabolism-epigenetic interaction-based bone and dental regeneration: From impacts and mechanisms to treatment potential

Chen, X., Huang, X., Zhang, X., & Chen, Z. (2024) · Bone · doi:10.1016/j.bone.2024.117382 · Cited by 9 · see citing works

An Epigenome-Wide Association Study of Inflammatory Response to Fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network

Yusuf, N., Hidalgo, B., Irvin, M. R., Sha, J., Zhi, D., Tiwari, H. K., Absher, D., Arnett, D. K., & Aslibekyan, S. W. (2017) · Pharmacogenomics · doi:10.2217/pgs-2017-0037 · Cited by 9 · see citing works

Betaine and L-Carnitine Synergistically Influence the Metabolome and Immune Response in Dogs

Jewell, D. E., Tavener, S. K., Creech, R., & Panickar, K. S. (2024) · Animals · doi:10.3390/ani14030357 · Cited by 8 · see citing works

Maternal Plasma Pyridoxal 5′-Phosphate Concentration Is Inversely Associated with Plasma Cystathionine Concentration across All Trimesters in Healthy Pregnant Women

Mujica-Coopman, M. F., Farias, D. R., Franco‐Sena, A. B., Vaz, J. D. S., Kac, G., & Lamers, Y. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz082 · Cited by 8 · see citing works

Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans

Guilbaud, A., Ghanegolmohammadi, F., Wang, Y., Leng, J., Kreymerman, A., Varela, J. G., Garbern, J. C., Elwell, H., Cao, F., Ricci-Blair, E. M., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad822 · Cited by 8 · see citing works

Metabolic Profiling of a Porcine Combat Trauma-Injury Model Using NMR and Multi-Mode LC-MS Metabolomics—A Preliminary Study

Laserna, A. K. C., Lai, Y., Fang, G., Rajaseger, G., Atan, M. S. B. M., Lu, J., Wu, J., Uttamchandani, M., Moochhala, S., & Li, S. F. Y. (2020) · Metabolites · doi:10.3390/metabo10090373 · Cited by 7 · see citing works

Associations of serum betaine with blood pressure and hypertension incidence in middle-aged and older adults: a prospective cohort study

Huang, R.-Z., Ma, J.-F., Chen, S. X., Chen, Y., Fang, A., Lu, X., Huang, Z., Zhu, H., & Huang, B. (2023) · Food & Function · doi:10.1039/d3fo00325f · Cited by 7 · see citing works

Partial Response to Antidepressant Treatment: The Role of Nutraceutical Compounds.

Girone, N., Benatti, B., Molteni, L., Cassina, N., Giacovelli, L., Arici, C., & Dell’Osso, B. M. (2023) · PubMed Central · doi:10.36131/cnfioritieditore20230303 · Cited by 6 · see citing works

S-Adenosylmethionine, a Promising Antitumor Agent in Oral and Laryngeal Cancer

Mosca, L., Vitiello, F., Pagano, M., Coppola, A., Tranchese, R. V., Grillo, R., Cacciapuoti, G., & Porcelli, M. (2022) · Applied Sciences · doi:10.3390/app12031746 · Cited by 6 · see citing works

Biomarker RIPK3 Is Silenced by Hypermethylation in Melanoma and Epigenetic Editing Reestablishes Its Tumor Suppressor Function

Villora, S. A., Silva, P. C., Zenz, T., Kwon, J. S., Schlaudraff, N. A., Nitaj, D., Meckbach, C., Dammann, R., & Richter, A. M. (2024) · Genes · doi:10.3390/genes15020175 · Cited by 5 · see citing works

Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1α activation

Klement, L., Jansakun, C., Yan, B., Staffer, S., Tuma‐Kellner, S., Altamura, S., Muckenthaler, M. U., Merle, U., & Chamulitrat, W. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167016 · Cited by 5 · see citing works

S-adenosyl-L-methionine supplementation alleviates aortic dissection by decreasing inflammatory infiltration

Wang, Q., An, J., Zhou, W., Zhang, Y., Huang, J., Liao, G., Wang, M., Xia, L., Le, A., & Zhu, J. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00837-5 · Cited by 5 · see citing works

A quantitative case study assessment of changes to hepatic metabolism from nonlactating grazing dairy cows consuming a large proportion of their diet as fodder beet

Grala, T. M., Handley, R. R., Phyn, C. V. C., Roche, J. R., & Dalley, D. E. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-16009 · Cited by 5 · see citing works

SAHH Deficiency Decreases Stability of Atherosclerotic Plaque and Induces VSMC Phenotype Switching via Epigenetic Upregulation of KLF4 and OCT4

Liu, S., Huang, T., Pan, M. R., Wang, Y., Dai, X., Liu, C., Huang, H., Ling, W., Li, B., He, Y., et al. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.324115 · Cited by 4 · see citing works

The Use of Complementary and Alternative Medicine in Management of Hidradenitis Suppurativa

Jain, S., O’Brien, J. C., & Harris-Tryon, T. A. (2024) · Current Dermatology Reports · doi:10.1007/s13671-024-00449-5 · Cited by 4 · see citing works

Polyphenols-mediated immune regulation: Metabolite-driven epigenetic regulatory mechanisms

Ouyang, B., Wu, Q., Liang, J., Cao, H., & Xiao, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157535 · Cited by 4 · see citing works

The gene regulatory networks shaping macrophage plasticity and altered function in fibrosis

Kolostyák, Z., & Nagy, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1767954 · Cited by 5 · see citing works

Emerging roles for methionine metabolism in immune cell fate and function

Liu, S., Tang, X., Huang, M., Tang, J., & Yang, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1701505 · Cited by 3 · see citing works

Integrated transcriptomic and metabolomic analysis reveals the effects of EMMPRIN on nucleotide metabolism and 1C metabolism in AS mouse BMDMs

Zhang, Y., Zhang, D., Xie, Z., Xia, T., Zou, L., Wang, T., Li, Z., Zeng, Z., Wang, L., Chen, G., et al. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1460186 · Cited by 3 · see citing works

The role of global DNA methylation in citrinin induced toxicity: In vitro and in silico approach

Cakir, M. C., & Özden, S. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.102046 · Cited by 3 · see citing works

Virulent Mycobacterium avium subspecies hominissuis subverts macrophages during early stages of infection

Ndzeidze, R., Leestemaker-Palmer, A., Danelishvili, L., & Bermudez, L. E. (2022) · Microbiology · doi:10.1099/mic.0.001133 · Cited by 3 · see citing works

MAT2A inhibition suppresses inflammation in Porphyromonas gingivalis -infected human gingival fibroblasts

Jiang, L., Li, J., Ji, K., Lei, L., & Li, H. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2292375 · Cited by 3 · see citing works

Prenatal Methyl Nutrient Availability Shapes Mesolimbic Dopaminergic Circuitry and Systemic Inflammation in Wistar Rat Offspring of Both Sexes

Pierdomenico, C. D., Cook, W. S., Dong, J., Shelp, G. V., Poole, E. M., Burns, S. E., & Cho, C. Y. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70468 · Cited by 1 · see citing works

Epigenetic Therapies

Neidhart, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420194-1.00025-7 · Cited by 1 · see citing works

Characterising Changes in Lipid Homeostasis as an Anti-Cancer Mechanism of Action of Methylthio-DADMe-Immucillin-A

Salita, T. (2018) · doi:10.26686/wgtn.22757438

Multifactorial microbial networks shape aging and neurodegeneration

Kara, N. Z., Savaliya, J. H., & Blacher, E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18979-1.00002-2

S-adenosylmethionine supplementation to alleviate depression symptoms in patients with suboptimal response to standard antidepressive therapy: a perspective

Labhade, S., Bhole, R. P., & Jain, S. (2024) · East Asian Archives of Psychiatry · doi:10.12809/eaap2435

S-adenosyl-L-methionine modulates hippocampal DNA methylation, exerting fast and long-lasting anti-stress effects independent of alterations in TrkB-mTOR expression

Sales, A. J., Maciel, I. D. S., & Guimarães, F. S. (2025) · Pharmacological Research - Reports · doi:10.1016/j.prerep.2025.100032

Additional file 2 of Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study

Tang, Y., Chen, X., Chen, Q., Xiao, J., Mi, J., Liu, Q., You, Y., Chen, Y., & Ling, W. (2022) · Figshare · doi:10.6084/m9.figshare.19386739

Additional file 2 of Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation

de Queiroz, K. B., Cavalcante‐Silva, V., Lopes, F. L., Rocha, G. A., D’Almeida, V., & Coimbra, R. S. (2020) · Figshare · doi:10.6084/m9.figshare.12061989

Additional file 1 of Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation

de Queiroz, K. B., Cavalcante‐Silva, V., Lopes, F. L., Rocha, G. A., D’Almeida, V., & Coimbra, R. S. (2020) · Figshare · doi:10.6084/m9.figshare.12061980

Additional file 1 of Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study

Tang, Y., Chen, X., Chen, Q., Xiao, J., Mi, J., Liu, Q., You, Y., Chen, Y., & Ling, W. (2022) · Figshare · doi:10.6084/m9.figshare.19386736

NMR-based serum metabolomics reveals diabetes-linked metabolic reprogramming in early-stage chronic kidney disease

Gupta, U., Sahu, A., Kaul, A., Mishra, J., Yadav, S. C., Behera, M., Baishya, B., & Sinha, N. (2026) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2026.117475

Hydrogen sulfide primes drought tolerance in plants by metabolic control of DNA methylation

Montesinos-Pereira, D., Zhang, J., Navarro, N., Zhuang, J., Zhao, H., Xie, Y., Gotor, C., & Romero, L. C. (2026) · iScience · doi:10.1016/j.isci.2026.117045

Multi-omics profiling reveals epigenetic alterations and a candidate SIRT1-β-catenin axis in bakuchiol ferulate-mediated photoaging protection

Liang, Y., Yan, Y., Cai, Z., Zhao, N., Zhong, J., & Shu, P. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1972459

S‐adenosylmethionine Lowers Inflammatory Response in Human Monocytic Cells (THP‐1) and Alters DNA Methylation

Pfalzer, A. C., Choi, S., Park, L. K., Bottiglieri, T., & Lamon‐Fava, S. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.370.3

Methionine Attenuates Lipopolysaccharide-Induced Inflammatory Responses via DNA Methylation in Macrophages

Ji, J., Xu, Y., Zheng, M., Luo, C., Lei, H., Qu, H., & Shu, D. (2019) · ACS Omega · doi:10.1021/acsomega.8b03571 · Cited by 57 · see citing works

S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation

Iglesias–Ara, A., Xia, M., Ramani, K., Mato, J. M., & Lu, S. C.-L. (2008) · Hepatology · doi:10.1002/hep.22231 · Cited by 114 · see citing works

Inhibition of lipopolysaccharide-stimulated TNF-α promoter activity byS-adenosylmethionine and 5′-methylthioadenosine

Veal, N., Hsieh, C., Xiong, S., Mato, J. M., Lu, S. C.-L., & Tsukamoto, H. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00316.2003 · Cited by 67 · see citing works

S-Adenosylmethionine Decreases Lipopolysaccharide-Induced Phosphodiesterase 4B2 and Attenuates Tumor Necrosis Factor Expression via cAMP/Protein Kinase A Pathway

Gobejishvili, L., Avila, D. V., Barker, D. F., Ghare, S. S., Henderson, D., Brock, G. N., Kirpich, I., Joshi‐Barve, S., Mokshagundam, S. P., McClain, C. J., et al. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.174268 · Cited by 44 · see citing works