The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal
Abstract
Hibernation in mammals requires a metabolic shift away from the oxidation of carbohydrates and toward the combustion of stored fatty acids as the primary source of energy during torpor. A key element involved in this fuel selection is pyruvate dehydrogenase kinase isoenzyme 4 (PDK4). PDK4 inhibits pyruvate dehydrogenase and thus minimizes carbohydrate oxidation by preventing the flow of glycolytic products into the tricarboxylic acid cycle. This paper examines expression of the PDK4 gene during hibernation in heart, skeletal muscle, and white adipose tissue (WAT) of the 13-lined ground squirrel, Spermophilus tridecemlineatus. During hibernation PDK4 mRNA levels increase 5-fold in skeletal muscle and 15-fold in WAT compared with summer-active levels. Similarly, PDK4 protein is increased threefold in heart, fivefold in skeletal muscle, and eightfold in WAT. High levels of serum insulin, likely to have an inhibitory effect on PDK4 gene expression, are seen during fall when PDK4 mRNA levels are low. Coordinate upregulation of PDK4 in three distinct tissues suggests a common signal that regulates PDK4 expression and fuel selection during hibernation.
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Cites
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Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164
Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116
Cited by
Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature
CAREY, H. V., ANDREWS, M. T., & MARTIN, S. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00008.2003 · Cited by 1,147
Self-citationAragonés, J., Schneider, M., Van Geyte, K., Fraisl, P., Dresselaers, T., Mazzone, M., Dirkx, R., Zacchigna, S., Lemieux, H., Jeoung, N. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.2007.62 · Cited by 472
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
Fraisl, P., Aragonés, J., & Carmeliet, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2761 · Cited by 326
Lee, C.-K., Allison, D. B., Brand, J., Weindruch, R., & Prolla, T. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232308999 · Cited by 314
ANNUAL LIPID CYCLES IN HIBERNATORS: Integration of Physiology and Behavior
John, D. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092514 · Cited by 300
Metadata
- Authors
- BUCK, M. J., SQUIRE, T. L., & ANDREWS, M. T.
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2002-02-11
- Volume
- 8
- Issue
- 1
- Pages
- 5-13
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- OpenAlex
- W2164209362
- Cited by
- 164
- References
- 3
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- BUCK, M. J., SQUIRE, T. L., & ANDREWS, M. T. (2002). Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal. Physiological Genomics. https://doi.org/10.1152/physiolgenomics.00076.2001
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