The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gene expression profiling reveals a regulatory role for RORα and RORγ in phase I and phase II metabolism
Abstract
Retinoid-related orphan receptors alpha (RORα) and gamma (RORγ) are both expressed in liver; however, their physiological functions in this tissue have not yet been clearly defined. The RORα1 and RORγ1 isoforms, but not RORα4, show an oscillatory pattern of expression during circadian rhythm. To obtain insight into the physiological functions of ROR receptors in liver, we analyzed the gene expression profiles of livers from WT, RORα-deficient staggerer (sg) mice ( RORα sg/sg), RORγ−/−, and RORα sg/sg RORγ−/− double knockout (DKO) mice by microarray analysis. DKO mice were generated to study functional redundancy between RORα and RORγ. These analyses demonstrated that RORα and RORγ affect the expression of a number of genes. RORα and RORγ are particularly important in the regulation of genes encoding several phase I and phase II metabolic enzymes, including several 3β-hydroxysteroid dehydrogenases, cytochrome P450 enzymes, and sulfotransferases. In addition, our results indicate that RORα and RORγ each affect the expression of a specific set of genes but also exhibit functional redundancy. Our study shows that RORα and RORγ receptors influence the regulation of several metabolic pathways, including those involved in the metabolism of steroids, bile acids, and xenobiotics, suggesting that RORs are important in the control of metabolic homeostasis.
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Cites
Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620
All-trans retinoic acid is a ligand for the orphan nuclear receptor RORβ
Stehlin-Gaon, C., Willmann, D., Zeyer, D., Sanglier, S., Van Dorsselaer, A., Renaud, J.-P., Moras, D., & Schüle, R. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb979 · Cited by 231
Cited by
T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605
Self-citationBile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
Jetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 673
Self-citationMedicine in the Fourth Dimension
Cederroth, C. R., Albrecht, U., Bass, J., Brown, S. A., Dyhrfjeld-Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich-Förster, C., Hogenesch, J. B., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.019 · Cited by 359
The circadian clock and liver function in health and disease
Mukherji, A., Bailey, S. M., Staels, B., & Baumert, T. F. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.020 · Cited by 246
Metadata
- Authors
- Kang, H. S., Angers, M., Beak, J. Y., Wu, X., Gimble, J. M., Wada, T., Xie, W., Collins, J. B., Grissom, S. F., & Jetten, A. M.
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2007-10
- Volume
- 31
- Issue
- 2
- Pages
- 281-294
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- OpenAlex
- W2145966572
- Cited by
- 186
- References
- 2
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kang, H. S., Angers, M., Beak, J. Y., Wu, X., Gimble, J. M., Wada, T., Xie, W., Collins, J. B., Grissom, S. F., & Jetten, A. M. (2007). Gene expression profiling reveals a regulatory role for RORα and RORγ in phase I and phase II metabolism. Physiological Genomics. https://doi.org/10.1152/physiolgenomics.00098.2007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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