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A novel, sensitive detection system for high-density microarrays using dendrimer technology
Abstract
Stears, Robin L., Robert C. Getts, and Steven R. Gullans. A novel, sensitive detection system for high-density microarrays using dendrimer technology. Physiol Genomics 3: 93–99, 2000.—To improve signal detection on cDNA microarrays, we adapted a fluorescent oligonucleotide dendrimeric signal amplification system to microarray technology. This signal detection method requires 16-fold less RNA for probe synthesis, does not depend on the incorporation of fluorescent dNTPs into a reverse transcription reaction, generates a high signal-to-background ratio, and can be used to allow for multichannel detection on a single chip. Furthermore, since the dendrimers can be detected individually, it may be possible, by employing dendrimer-binding standards, to calculate the numbers of bound cDNAs can be estimated. These features make the dendrimer signal detection reagent ideal for high-throughput functional genomics research.
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Citations
Cited by
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Dendrimers in biomedical applications—reflections on the field
SVENSON, S., & TOMALIA, D. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.018 · Cited by 1,919
Dendrimers in biomedical applications—reflections on the field
Svenson, S., & Tomalia, D. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.030 · Cited by 593
John, G. R., Shankar, S. L., Shafit-Zagardo, B., Massimi, A., Lee, S. C., Raine, C. S., & Brosnan, C. F. (2002) · Nature Medicine · doi:10.1038/nm781 · Cited by 477
Metadata
- Authors
- STEARS, R. L., GETTS, R. C., & GULLANS, S. R.
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2000-08-09
- Volume
- 3
- Issue
- 2
- Pages
- 93-99
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- OpenAlex
- W2186957524
- Cited by
- 216
- References
- 0
- FWCI
- 82.91
- Type
- journal article
- Language
- en
- Open access
- closed
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