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Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?
Abstract
Intracellular acidosis due mainly to lactic acid accumulation has been regarded as the most important cause of skeletal muscle fatigue. Recent studies on mammalian muscle, however, show little direct effect of acidosis on muscle function at physiological temperatures. Instead, inorganic phosphate, which increases during fatigue due to breakdown of creatine phosphate, appears to be a major cause of muscle fatigue.
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Citations
Cited by
Skeletal muscle fatigue: cellular mechanisms
Allen, D. G., Lamb, G. D., & Westerblad, H. (2008) · Physiological Reviews · doi:10.1152/physrev.00015.2007 · Cited by 2,495
Self-citationExercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459
Biochemistry of exercise-induced metabolic acidosis
Robergs, R. A., Ghiasvand, F., & Parker, D. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00114.2004 · Cited by 1,304
Repeated-Sprint Ability – Part I: Factors Contributing to Fatigue
Girard, O., Mendez-Villanueva, A., & Bishop, D. (2011) · Sports Medicine · doi:10.2165/11590550-000000000-00000 · Cited by 916
Glaister, M. (2005) · Sports Medicine · doi:10.2165/00007256-200535090-00003 · Cited by 561
Metadata
- Authors
- Westerblad, H., Allen, D. G., & Lännergren, J.
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2002-02
- Volume
- 17
- Issue
- 1
- Pages
- 17-21
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W1871704467
- Cited by
- 576
- References
- 0
- FWCI
- 45.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Westerblad, H., Allen, D. G., & Lännergren, J. (2002). Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause? Physiology. https://doi.org/10.1152/physiologyonline.2002.17.1.17
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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