Nongenomic steroid action: controversies, questions, and answers

LÖSEL, RALF M., FALKENSTEIN, ELISABETH, FEURING, MARTIN, SCHULTZ, ARMIN, TILLMANN, HANNS-CHRISTIAN, ROSSOL-HASEROTH, KARIN, WEHLING, MARTIN·2003·Physiological Reviews

DOI 10.1152/physrev.00003.2003

Cites (562)

Items 201–400 of 562

The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study
Marco Pistis, Delia Belelli, John A. Peters, Jeremy J. Lambert · 1997 · British Journal of Pharmacology
Rapid Nongenomic Effects of Aldosterone in Mineralocorticoid-Receptor-Knockout Mice
K Rossol-Haseroth, Dirk Gerdes, Stefan M. Berger, Martin Feuring, Andreas Guenther, Christel Herbst, Michael Christ, Martin Wehling · 1999 · Biochemical and Biophysical Research Communications
Testosterone induces Ca2+ influx via non‐genomic surface receptors in activated T cells
W. Peter M. Benten, Michèle Lieberherr, Constantin E. Sekeris, Frank Thomas Wunderlich · 1997 · FEBS Letters
The Direct Vasomotor Effect of Thyroid Hormones on Rat Skeletal Muscle Resistance Arteries
Kyung W. Park, Hai B. Dai, Kaie Ojamaa · 1997 · Anesthesia & Analgesia
Androgens rapidly increase the cytosolic calcium concentration in Sertoli cells
E. Gorczynska · 1995 · Endocrinology
At least three promoters direct expression of the mouse glucocorticoid receptor gene.
Uwe Strähle, Andrea Schmidt, Gavin Kelsey, A. Francis Stewart, T J Cole, Wolfgang Schmid, G. Schütz · 1992 · Proceedings of the National Academy of Sciences
Characterization of aldosterone binding sites in circulating human mononuclear leukocytes
Decio Armanini, T. Strasser, Christian Weber · 1985 · American Journal of Physiology-Endocrinology and Metabolism
Rapid Non-Genomic Feedback Effects of Glucocorticoids on CRF-Induced ACTH Secretion in Rats
Burkhard Hinz, Rolf Hirschelmann · 2000 · Pharmaceutical Research
Estradiol Signaling via Sequestrable Surface Receptors
W. Peter M. Benten · 2001 · Endocrinology
Antibodies to the estrogen receptor‐α modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors
Andrea M. Norfleet, Charlotte H. Clarke, Bahiru Gametchu, Cheryl S. Watson · 2000 · The FASEB Journal
Perimembrane Localization of the Estrogen Receptor α Protein in Neuronal Processes of Cultured Hippocampal Neurons
Charlotte H. Clarke, Andrea M. Norfleet, Mark S. F. Clarke, Cheryl S. Watson, Kathryn A. Cunningham, Mary L. Thomas · 2000 · Neuroendocrinology
The Intracellular Localization of the Mineralocorticoid Receptor Is Regulated by 11β-Hydroxysteroid Dehydrogenase Type 2
Alex Odermatt, Peter Arnold, Felix Julius Frey · 2001 · Journal of Biological Chemistry
Rapid Behavioral Response to Corticosterone Varies with Photoperiod and Dose
Creagh W. Breuner, John C. Wingfield · 2000 · Hormones and Behavior
Direct Activation of Protein Kinase C by 1α,25-Dihydroxyvitamin D3
Simon J. Slater, Mary Beth Kelly, Frank J. Taddeo, Jonathan D. Larkin, Mark D. Yeager, John A. McLane, Cojen Ho, Christopher D. Stubbs · 1995 · Journal of Biological Chemistry
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons
Kazuhiro Honda, Shun Shimohama, Hideyuki Sawada, Takeshi Kihara, Tomoki Nakamizo, H. Shibasaki, Akinori Akaike · 2001 · Journal of Neuroscience Research
The Classical Progesterone Receptor Associates with p42 MAPK and Is Involved in Phosphatidylinositol 3-Kinase Signaling inXenopus Oocytes
Christoph P. Bagowski, Jason W. Myers, James E. Ferrell · 2001 · Journal of Biological Chemistry
Membrane Receptors for Steroid Hormones: A Case for Specific Cell Surface Binding Sites for Vitamin D Metabolites and Estrogens
Ilka Nemere, Mary C. Farach‐Carson · 1998 · Biochemical and Biophysical Research Communications
The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task
Chantal Mathis, Steven M. Paul, Jacqueline N. Crawley · 1994 · Psychopharmacology
Stimulation of Phosphorylation of Mitogen-Activated Protein Kinase by 1α,25-Dihydroxyvitamin D3 in Promyelocytic NB4 Leukemia Cells: A Structure-Function Study*
Xinde Song, June E. Bishop, William H. Okamura, Anthony W. Norman · 1998 · Endocrinology
Specific Progesterone Binding to a Membrane Protein and Related Nongenomic Effects on Ca2+-Fluxes in Sperm
Elisabeth Falkenstein, Marina Heck, Dirk Gerdes, D. Forssmann Grube, Michael Christ, Michael Weigel, Madhavee Buddhikot, Stanley Meizel, Martin Wehling · 1999 · Endocrinology
Comparison of 6-s-cis- and 6-s-trans-Locked Analogs of 1α,25-Dihydroxyvitamin D3 Indicates That the 6-s-cis Conformation Is Preferred for Rapid Nongenomic Biological Responses and That Neither 6-s-cis- nor 6-s-trans-Locked Analogs Are Preferred for Genomic Biological Responses
Anthony W. Norman, William H. Okamura, Marion W. Hammond, June E. Bishop, Murray C. Dormanen, Roger Bouillon, Hugo VAN BAELEN, Amy L. Ridall, E. Daane, Ramzi Khoury et al. · 1997 · Molecular Endocrinology
Isolation and characterization of a novel gene induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in rat liver
Ornella I. Selmin, George W. Lucier, George C. Clark, Angelika M. Tritscher, John P. Vanden Heuvel, Jonathan A. Gastel, Nigel J. Walker, Thomas R. Sutter, Douglas A. Bell · 1996 · Carcinogenesis
Estrogen induces a rapid secretion of amyloid β precursor protein via the mitogen‐activated protein kinase pathway
Dieter Manthey, Stefanie Heck, Stefanie Engert, Christian Behl · 2001 · European Journal of Biochemistry
Thyroid Hormone Promotes Serine Phosphorylation of p53 by Mitogen-Activated Protein Kinase
Ai Shih, Hung‐Yun Lin, Faith B. Davis, Paul J. Davis · 2001 · Biochemistry
Rapid Androgen Actions on Calcium Signaling in Rat Sertoli Cells and Two Human Prostatic Cell Lines: Similar Biphasic Responses Between 1 Picomolar and 100 Nanomolar Concentrations1
Fiona M. Lyng, Gareth R. Jones, FOCKO F. G. ROMMERTS · 2000 · Biology of Reproduction
Rapid Cardiovascular Action of Aldosterone in Man1
Martin Wehling, Christoph H. Spes, Nini Win, Catherine P. Janson, Bernhard M. W. Schmidt, K. Theisen, Michael Christ · 1998 · The Journal of Clinical Endocrinology & Metabolism
Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3
Stefania Morelli, Ana Russo de Boland, R. Boland · 1993 · Biochemical Journal
Extracellular matrix is required for skeletal muscle differentiation but not myogenin expression
Francisco Melo, David J. Carey, Enrique Brandan · 1996 · Journal of Cellular Biochemistry
Use of receptor antibodies to demonstrate membrane glucocorticoid receptor in cells from human leukemic patients
Bahiru Gametchu, Cheryl S. Watson, Shenhong Wu · 1993 · The FASEB Journal
Modulation of corticotrophin-releasing factor release from hypothalamic synaptosomes
James Alexander Edwardson, G.W. Bennett · 1974 · Nature
Aldosterone reduces baroreceptor discharge in the dog.
W Wang, J M McClain, Irving H. Zucker · 1992 · Hypertension
Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action
Martin Wehling, Michael Christ, K. Theisen · 1992 · American Journal of Physiology-Endocrinology and Metabolism
Rapid Effects of Aldosterone on Free Intracellular Calcium in Vascular Smooth Muscle and Endothelial Cells: Subcellular Localization of Calcium Elevations by Single Cell Imaging
Martin Wehling, Axel Ulsenheimer, Manfred P Schneider, Craig B. Neylon, Michael Christ · 1994 · Biochemical and Biophysical Research Communications
Neuroprotective activity of a new class of steroidal inhibitors of the N -methyl- d -aspartate receptor
Charles E. Weaver, Przemysław Marek, Mijeong Park-Chung, S. William Tam, David H. Farb · 1997 · Proceedings of the National Academy of Sciences
Androgens rapidly increase the cytosolic calcium concentration in Sertoli cells.
E Gorczynska, David J. Handelsman · 1995 · Endocrinology
Nongenomic effects of aldosterone on Ca2+ in M-1 cortical collecting duct cells
Brian Joseph Harvey, Maria Higgins · 2000 · Kidney International
An Insulinotropic Effect of Vitamin D Analog with Increasing Intracellular Ca2+ Concentration in Pancreatic β-Cells through Nongenomic Signal Transduction1
Mariko Kajikawa, Hitoshi Ishida, Shimpei Fujimoto, Eri Mukai, Masayoshi Nishimura, Jun Fujita, Yoshiyuki Tsuura, Yoshimasa Okamoto, Anthony W. Norman, Yutaka Seino · 1999 · Endocrinology
Rapid inhibition of rat brain mitochondrial proton F0F1-ATPase activity by estrogens: comparison with Na+, K+-ATPase of porcine cortex
Jianbiao Zheng, Victor Domingo Ramirez · 1999 · European Journal of Pharmacology
Structure, chromosomal localization, and brain expression of human Cx36 gene
Natale Belluardo, Angela Trovato Salinaro, Giuseppa Mudò, Yasmin L. Hurd, D. F. Condorelli · 1999 · Journal of Neuroscience Research
Direct action of aldosterone on transmembrane 22Na efflux from arterial smooth muscle. Rapid and delayed effects.
A M Moura, Manuel Worcel · 1984 · Hypertension
Evidence for Involvement of Protein Kinase C and Cyclic Adenosine 3’,5’ Monophosphate-Dependent Protein Kinase in the 1,25-Dihydroxy-Vitamin D3-Mediated Rapid Stimulation of Intestinal Calcium Transport, (Tr anscaltachia)*
Ana Russo de Boland, Anthony W. Norman · 1990 · Endocrinology
Ion fluxes through the progesterone-activated channel of the sperm plasma membrane
Carlo Foresta, Marco Rossato, Francesco Di Virgilio · 1993 · Biochemical Journal
The effects of steroid hormones on electrical activity of excitable cells
Harold H. Zakon · 1998 · Trends in Neurosciences
Effects of a naturally occurring neurosteroid on GABAA IPSCs during development in rat hippocampal or cerebellar slices
Elizabeth J. Cooper, Graham A.R. Johnston, Frances A. Edwards · 1999 · The Journal of Physiology
Estradiol Signaling via Sequestrable Surface Receptors
W. Peter M. Benten, Christian Stephan, Michèle Lieberherr, Frank Thomas Wunderlich · 2001 · Endocrinology
Progesterone-Induced Acrosome Reaction in Stallion Spermatozoa Is Mediated by a Plasma Membrane Progesterone Receptor
Feng‐Pang Cheng, Bart M. Gadella, Wim F. Voorhout, Alireza Fazeli, MART M. BEVERS, Ben Colenbrander · 1998 · Biology of Reproduction
1,25-Dihydroxyvitamin D3Induced Activation and Subsequent Nuclear Translocation of MAPK Is Upstream Regulated by PKC in HL-60 Cells
Ewa Marcinkowska, Antoni Więdłocha, Czesław Radzikowski · 1997 · Biochemical and Biophysical Research Communications
Progesterone Triggers a Wave of Increased Free Calcium during the Human Sperm Acrosome Reaction
Stanley Meizel, Kenneth O. Turner, Richard Nuccitelli · 1997 · Developmental Biology
The acrosome reaction in human spermatozoa
Catherine Patrat, Catherine Serres, Pierre Jouannet · 2000 · Biology of the Cell
Evidence for a Specific Estradiol Binding Site on Rat Pituitary Membranes
DOMINIQUE BRESSION, M. MICHARD, M. Le Dafniet, Patrick Pagésy, F Peillon · 1986 · Endocrinology
Novel mechanism for non‐genomic action of 17β‐oestradiol on kainate‐induced currents in isolated rat CA1 hippocampal neurones
Qin Gu, Robert L. Moss · 1998 · The Journal of Physiology
An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1,6-bisphosphate
Kiyoto Ashizawa, Peter McPhie, Kwang‐Huei Lin, Sheue Yann Cheng · 1991 · Biochemistry
DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range
Elisabeth Frieß, L. Trachsel, Jürgen Guldner, T. Schier, Axel Steiger, F. Holsboer · 1995 · American Journal of Physiology-Endocrinology and Metabolism
Increase in extracellular acetylcholine level by sigma ligands in rat frontal cortex.
Kiyoshi Matsuno, K Matsunaga, Toshihiko Senda, S. Mita · 1993 · Journal of Pharmacology and Experimental Therapeutics
Stimulation by 1α,25(OH)2-Vitamin D3 of Whole Cell Chloride Currents in Osteoblastic ROS 17/2.8 Cells
Laura P. Zanello, Anthony W. Norman · 1997 · Journal of Biological Chemistry
Progesterone and RU486: opposing effects on human sperm.
J Yang, Catherine Serres, D. Philibert, P Röbel, E.E. Baulieu, Pierre Jouannet · 1994 · Proceedings of the National Academy of Sciences
Thyroid hormone promotes the phosphorylation of STAT3 and potentiates the action of epidermal growth factor in cultured cells
Hung‐Yun Lin, Ai Shih, Faith B. Davis, Paul J. Davis · 1999 · Biochemical Journal
Aldosterone- and testosterone-mediated intracellular calcium response in skeletal muscle cell cultures
Manuel Estrada, José Luis Liberona, Manuel Miranda, Enrique Jaimovich · 2000 · American Journal of Physiology-Endocrinology and Metabolism
Rapid activation of Na + /H + -exchange in MDCK cells by aldosterone involves MAP-kinases ERK 1/2
Michael Gekle, Ruth Freudinger, Sigrid Mildenberger, Kai Schenk, Ingrid Marschitz, Herbert Schramek · 2001 · Pflügers Archiv - European Journal of Physiology
Inhibition by steroids of [14C]-guanidinium flux through the voltage-gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells
Martin Barann, Manfred Göthert, Michael Brüss, Heinz Bönisch · 1999 · Naunyn-Schmiedeberg s Archives of Pharmacology
G Protein βγ Subunits Inhibit Nongenomic Progesterone-induced Signaling and Maturation in Xenopus laevis Oocytes
Lindsey B. Lutz, Bonnie Kim, David Jahani, Stephen R. Hammes · 2000 · Journal of Biological Chemistry
Estradiol membrane binding sites on human breast cancer cell lines. Use of a fluorescent estradiol conjugate to demonstrate plasma membrane binding systems
Yolande Berthois, N Pourreau-Schneider, Philippe Gandilhon, Hervé Mittre, N. Tubiana-Mathieu, Pierre‐Marie Martin · 1986 · Journal of Steroid Biochemistry
Aldosterone blunts the baroreflex response in man
K. M. YEE, Allan D. Struthers · 1998 · Clinical Science
Reduction of rat pup ultrasonic vocalizations by the neuroactive steroid allopregnanolone
Betty Zimmerberg, Susan A. Brunelli, Myron A. Hofer · 1994 · Pharmacology Biochemistry and Behavior
Rapid Effects of 1,25-Dihydroxyvitamin D3and Extracellular Ca2+on Phospholipid Metabolism in Dispersed Porcine Parathyroid Cells
A. Bourdeau, Fouad Atmani, Brigitte Grosse, Michèle Lieberherr · 1990 · Endocrinology
1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2
B Boyanabc · 1999 · Steroids
The Role of Neurosteroids and Nongenomic Effects of Progestins in the Ventral Tegmental Area in Mediating Sexual Receptivity of Rodents
Cheryl Anne Frye · 2001 · Hormones and Behavior
The coupling of multiple signal transduction pathways with steroid response mechanisms.
Steven K. Nordeen, Marissa L. Moyer, Betty J. Bona · 1994 · Endocrinology
Selective expression of a progesterone receptor on the human sperm surface
Jan Tesařík, Carmen Mendoza, Jiří Moos, Alfonso Carreras · 1992 · Fertility and Sterility
Neuroactive steroids: their mechanism of action and their function in the stress response
Zinder, Dar · 1999 · Acta Physiologica Scandinavica
Plasma membrane-resident glucocorticoid receptors in rodent lymphoma and human leukemia models
B Gametchua · 1999 · Steroids
Structure-function studies of 1,25-dihydroxyvitamin D3 and the vitamin D endocrine system. 1,25-dihydroxy-pentadeuterio-previtamin D3 (as a 6-s-cis analog) stimulates nongenomic but not genomic biological responses
Anthony W. Norman, W. H. OKAMURA, Mary C. Farach‐Carson, Katrien Allewaert, D Branisteanu, Ilka Nemere, K.R. Muralidharan, Roger Bouillon · 1993 · Journal of Biological Chemistry
The neurosteroid pregnenolone sulfate blocks deficits induced by a competitive NMDA antagonist in active avoidance and lever-press learning tasks in mice
Chantal Mathis, Elise Vogel, Barbara Cagniard, François Criscuolo, Arielle Ungerer · 1996 · Neuropharmacology
Acute and Nongenomic Effects of Testosterone on Isolated and Perfused Rat Heart
Guillermo Manuel Ceballos, Figueroa‐Valverde Lauro, Ivan Rubio‐Gayosso, Gabriel Milanés Gallo, Alicia García, Alin Martinez, Ricardo Yañez, Juana Pérez, Tomás Morato, G Chamorro · 1999 · Journal of Cardiovascular Pharmacology
Effects of thyroid hormone on action potential and repolarizing currents in rat ventricular myocytes
Zhuoqian Sun, Kaie Ojamaa, William A. Coetzee, Michael Artman, Irwin L. Klein · 2000 · American Journal of Physiology-Endocrinology and Metabolism
Rapid Neurophysiological Effects of Corticosterone on Medullary Neurons: Relationship to Stress-Induced Suppression of Courtship Clasping in an Amphibian
James D. Rose, Frank L. Moore, Miles Orchinik · 2008 · Neuroendocrinology
Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor
Pankaj Seth, Malliga E. Ganapathy, Simon James Conway, Christy D Bridges, Sylvia B. Smith, Pierre Casellas, Vadivel Ganapathy · 2001 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
17β‐Oestradiol acutely regulates Cl− secretion in rat distal colonic epithelium
Steven B. Condliffe, Christina M. Doolan, Brian Joseph Harvey · 2001 · The Journal of Physiology
Steroids conjugated to bovine serum albumin as tools to demonstrate specific steroid neuronal membrane binding sites.
J Zheng, Alaa N. Mahammed Ali, V. DOMINGO RAMIREZ · 1996 · PubMed
Subunit-specific modulation of glycine receptors by neurosteroids
G. Maksay, Bodo Laube, Heinrich Betz · 2001 · Neuropharmacology
Rapid non‐genomic activation of cytosolic cyclic AMP‐dependent protein kinase activity and [Ca2+]i by 17β‐oestradiol in female rat distal colon
Christina M. Doolan, Steven B. Condliffe, Brian Joseph Harvey · 2000 · British Journal of Pharmacology
Progesterone-Mediated Efflux of Cytosolic Chloride During the Human Sperm Acrosome Reaction
Kenneth O. Turner, Stanley Meizel · 1995 · Biochemical and Biophysical Research Communications
Partial purification and biochemical characterization of a membrane glucocorticoid receptor from an amphibian brain
Simon J. Evans, Thomas F. Murray, Frank L. Moore · 2000 · The Journal of Steroid Biochemistry and Molecular Biology
Membrane Receptors for Corticosterone: A Mechanism for Rapid Behavioral Responses in an Amphibian
Frank L. Moore, Miles Orchinik · 1994 · Hormones and Behavior
Short-Term Effects of Thyroid Hormones on the Na/H Antiport in L-6 Myoblasts: High Molecular Specificity for 3,3′,5-Triiodo- l -Thyronine1
Sandra Incerpi, Paolo Luly, Paolo De Vito, Ricardo N. Farı́as · 1999 · Endocrinology
Acute stimulation of intestinal cell calcium influx induced by 17β-estradiol via the cAMP messenger system
Gabriela Picotto, Virginia Massheimer, Ricardo Boland · 1996 · Molecular and Cellular Endocrinology
Progesterone Mediates its Anti-Mitogenic and Anti-Apoptotic Actions in Rat Granulosa Cells Through a Progesterone-Binding Protein With Gamma Aminobutyric AcidA Receptor-Like Features1
John J. Peluso, A. Pappalardo · 1998 · Biology of Reproduction
Effects of steroids on gamma-aminobutyric acid receptors expressed in Xenopus oocytes by poly(A)+ RNA from mammalian brain and retina.
Richard M. Woodward, Lorenzo Polenzani, Ricardo Miledi · 1992 · Molecular Pharmacology
Effects of an anabolic-androgenic steroid on the regulation of the NMDA receptor NR1, NR2A and NR2B subunit mRNAs in brain regions of the male rat
Pierre Le Grevès, Wan Huang, Pia Johansson, Madeleine Thörnwall, Qin Zhou, Fred Nyberg · 1997 · Neuroscience Letters
Glycine receptors containing the α4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge
Robert J. Harvey, Volker Schmieden, Alexander von Holst, Bodo Laube, Hermann Rohrer, Heinrich Betz · 2000 · European Journal of Neuroscience
Stimulation by thyroid hormone analogues of red blood cell Ca2+-ATPase activity in vitro. Correlations between hormone structure and biological activity in a human cell system.
Faith B. Davis, Vivian Cody, Paul J. Davis, Leonard J. Borzynski, Susan D. Blas · 1983 · Journal of Biological Chemistry
Structural and Electrostatic Properties of the 5-HT3Receptor Pore Revealed by Substituted Cysteine Accessibility Mutagenesis
David C. Reeves, Eric N. Goren, Myles H. Akabas, Sarah C. R. Lummis · 2001 · Journal of Biological Chemistry
RAPID ALDOSTERONE‐INDUCED CELL VOLUME INCREASE OF ENDOTHELIAL CELLS MEASURED BY THE ATOMIC FORCE MICROSCOPE
STEFAN W. SCHNEIDER, Yoshiko Yano, Bauer E. Sumpio, Bhanu P. Jena, John Peter Geibel, Michael Gekle, Hans Oberleithner · 1997 · Cell Biology International
Short Term Cardiovascular Effects of Aldosterone in Healthy Male Volunteers
B. M. W. Schmidt, A. Montealegre, Catherine P. Janson, Nicole Martin, C. Stein-Kemmesies, Armin W. Scherhag, Martin Feuring, Michael Christ, Martin Wehling · 1999 · The Journal of Clinical Endocrinology & Metabolism
Steroid Inhibition of Rat Neuronal Nicotinic α4β2 Receptors Expressed in HEK 293 Cells
Kenneth G. Paradiso, Kimberley Sabey, Alex S. Evers, Charles F. Zorumski, Douglas F. Covey, Joe Henry Steinbach · 2000 · Molecular Pharmacology
Bursting of cardiac sodium channels after acute exposure to 3,5,3'-triiodo-L-thyronine.
Samuel C. Dudley, Clive Marc Baumgarten · 1993 · Circulation Research
Effects of estradiol and progesterone on voltage-gated calcium and potassium conductances in rat CA1 hippocampal neurons
Marian Joëls, Henk Karst · 1995 · Journal of Neuroscience
Estradiol increases cyclic adenosine monophosphate in rat pulmonary vascular smooth muscle cells by a nongenomic mechanism.
Michel Y. Farhat, Sylvie Abi-Younes, Brenda Dingaan, R Vargas, Peter W. Ramwell · 1996 · Journal of Pharmacology and Experimental Therapeutics
Acute effects of thyroid hormone on inward rectifier potassium channel currents in guinea pig ventricular myocytes.
Y Sakaguchi, G. Cui, Luyi Sen · 1996 · Endocrinology
Cutaneous rat wounds express C49a, a novel gene with homology to the human melanoma differentiation associated gene, Mda7
Chia B. Soo, William Wei-Lien Shaw, EARL G. FREYMILLER, Michael Thornton Longaker, Charles N. Bertolami, Robert Chiu, Andy Tieu, Ting Kang · 1999 · Journal of Cellular Biochemistry
Effects of androgen on intracellular calcium of LNCaP cells
Jaime Steinsapir, Robin R. Socci, Peter Sol Reinach · 1991 · Biochemical and Biophysical Research Communications
Retardation of Sodium Exchange in Dog Erythrocytes by Physiological Concentrations of Aldosterone, in Vitro*
Colette Spach, David H. P. Streeten · 1964 · Journal of Clinical Investigation
Distinct Specificity for Corticosteroid Binding Sites in Amphibian Cytosol, Neuronal Membranes, and Plasma
Miles Orchinik, Laura Matthews, Paul J. Gasser · 2000 · General and Comparative Endocrinology
Rapid activation of endothelial nitric oxide synthase by estrogen
Philip W. Shaul · 1999 · Steroids
Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases
Paul A. Lapchak, Dalia M. Araujo · 2001 · International review of neurobiology
Heterogeneity of Hippocampal GABAAReceptors: Regulation by Corticosterone
Miles Orchinik, Steven S. Carroll, Yi-Huey Li, Bruce S. McEwen, Nancy G. Weiland · 2001 · Journal of Neuroscience
Determinants of Specificity of Transactivation by the Mineralocorticoid or Glucocorticoid Receptor
Sylvia S. Lim-Tio, Maria-Cristina Keightley, Peter J. Fuller · 1997 · Endocrinology
The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice performing an appetitive learning task
Hamid Méziane, Chantal Mathis, Arielle Ungerer, Steven M. Paul · 1996 · Psychopharmacology
1,25-Dihydroxyvitamin D3 analog structure-function assessment of the rapid stimulation of intestinal calcium absorption (transcaltachia)
Lixin Zhou, Ilka Nemere, Anthony W. Norman · 1992 · Journal of Bone and Mineral Research
Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm
Leah M. Cataldo, Kashif M. Baig, Richard J. Oko, Mary-Ann A. Mastrangelo, Kenneth Cole Kleene · 1996 · Molecular Reproduction and Development
Different shapes of the steroid hormone 1α,25(OH)2-vitamin D3 act as agonists for two different receptors in the vitamin D endocrine system to mediate genomic and rapid responses☆11☆ Guest Editor: Dr. Satya Reddy, Proceedings of the First International Conference on Chemistry and Biology of Vitamin D Analogs, Brown University, Providence, RI.
Anthony W. Norman, Helen L. Henry, June E. Bishop, Xinde Song, Craig M. Bula, William H. Okamura · 2001 · Steroids
Plasma vasopressin, renin activity, and aldosterone: Effect of exercise and training
ANDRÉ GEYSSANT, Ghislaine Geelen, Ch. Denis, A. M. Allevard, M. Vincent, E. Jarsaillon, C Bizollon, Jean René Lacour, Cl. Gharib · 1981 · European Journal of Applied Physiology
Loss of Estrogen Inactivation in Colonic Cancer
M A English, Kate F. Kane, Neil Cruickshank, Michael J. S. Langman, Paul M. Stewart, Martin Hewison · 1999 · The Journal of Clinical Endocrinology & Metabolism
Nongenomic effects of progesterone on spermatozoa mechanisms of signal transduction and clinical implications
Elisabetta Baldi · 1998 · Frontiers in bioscience
ENDOCRINE RESPONSE TO EXERCISE
Ronald L. Terjung · 1979 · Exercise and Sport Sciences Reviews
Novel regulatory actions of 1α,25‐dihydroxyvitamin D3 on the metabolism of polyphosphoinositides in murine epidermal keratinocytes
Wilson Tang, Vincent A. Ziboh, R. Rivkah Isseroff, Deborah Martinez · 1987 · Journal of Cellular Physiology
Upregulation of the Maturation-Inducing Steroid Membrane Receptor in Spotted Seatrout Ovaries by Gonadotropin During Oocyte Maturation and Its Physiological Significance1
Peter Thomas, J. Pinter, Shampa Das · 2001 · Biology of Reproduction
Rapid and genomic biological responses are mediated by different shapes of the agonist steroid hormone, 1α,25(oh)2vitamin d3
Anthony W. Norman · 1999 · Steroids
Regulation of Xenopus oocyte meiosis arrest by G protein βγ subunits
Yinglun Sheng, Mario Tiberi, Ronald A. Booth, Chunqi Ma, X. Johné Liu · 2001 · Current Biology
Estrogen action at endometrial membranes: alterations in luminal surface detectable within seconds.
C O Rambo, Clara M. Szego · 1983 · The Journal of Cell Biology
Nongenomic Mechanisms of Glucocorticoid Inhibition of Nicotine-Induced Calcium Influx in PC12 Cells: Involvement of Protein Kinase C**This work was supported by a research grant from the Natural Science Foundation of China.
Jian Qiu, Li-Guang Lou, Xiu-Ying Huang, Shu-jie Lou, Gang Pei, Yi-Zhang Chen · 1998 · Endocrinology
Sex Hormone-Binding Globulin Mediates Prostate Androgen Receptor Action via a Novel Signaling Pathway
Victor D. H. Ding, David E. Moller, William P. Feeney, Varsha Didolkar, Atif M. Nakhla, Linda Rhodes, William Rosner, Roy G. Smith · 1998 · Endocrinology
Progesterone has rapid and membrane effects in the facilitation of female mouse sexual behavior
Cheryl Anne Frye, Jill M. Vongher · 1999 · Brain Research
The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells
Michael Gekle, Stefan Silbernagl, Hans Oberleithner · 1997 · American Journal of Physiology-Cell Physiology
The Effect of Triiodothyronine on 2-Deoxy-D-[l-3H]Glucose Uptake in Cultured Chick Embryo Heart Cells*
Joseph Segal, HENIA SCHWARTZ, Amirav Gordon · 1977 · Endocrinology
Non-classical receptors for aldosterone in plasma membranes from pig kidneys
Michael Christ, K. Sippel, Christoph Eisen, Martin Wehling · 1994 · Molecular and Cellular Endocrinology
Nongenomic Effects of Androstenedione on Human Granulosa Luteinizing Cells
Véronique Machelon, Françoise Nomé, Jan Tesařík · 1998 · The Journal of Clinical Endocrinology & Metabolism
Differentiation of σ ligand‐activated receptor subtypes that modulate NMDA‐evoked [3H]‐noradrenaline release in rat hippocampal slices
François P. Monnet, Brian R. de Costa, Wayne D. Bowen · 1996 · British Journal of Pharmacology
Localization of a putative progesterone membrane binding protein in porcine hepatocytes.
Elisabeth Falkenstein, Kerstin Schmieding, Aksel Lange, Carmen Meyer, Dirk Gerdes, Ulrich N. WELSCH, Martin Wehling · 1998 · PubMed
Nonnuclear Effects of the Steroid Hormone 1α,25(OH)2-Vitamin D3: Analogs Are Able to Functionally Differentiate Between Nuclear and Membrane Receptors
Murray C. Dormanen, J.E. Bishop, Marion W. Hammond, W. H. OKAMURA, Ilka Nemere, A. W. Norman · 1994 · Biochemical and Biophysical Research Communications
Membrane binding sites and non-genomic effects of estrogen in cultured human preosteoclastic cells
Gianna Fiorelli, Francesca Gori, Uliana Frediani, Francesco Franceschelli, Annalisa Tanini, Cristina Tosti‐Guerra, Susanna Benvenuti, Luigi Gennari, Lucia Becherini, Maria Luisa Brandi · 1996 · The Journal of Steroid Biochemistry and Molecular Biology
Characterization of a Putative Membrane Receptor for Progesterone in Rat Granulosa Cells1
John J. Peluso, G. Fernandez, A. Pappalardo, B A White · 2001 · Biology of Reproduction
Immunochemical studies on the putative plasmalemmal receptor for 1,25(OH)2D3. I. Chick intestine
Ilka Nemere, Rahul Ray, William R. McManus · 2000 · American Journal of Physiology-Endocrinology and Metabolism
Efects of corticosterone on the electrophysiology of hippocampal CA1 pyramidal Cells in vitro
Craig T. Reiheld, Timothy J. Teyler, Richard M. Vardaris · 1984 · Brain Research Bulletin
Alterations in basal firing rate and autoreceptor sensitivity of dopamine neurons in the substantia nigra following acute and extended exposure to estrogen
Louis A. Chiodo, Anthony R. Caggiula · 1980 · European Journal of Pharmacology
1α,25-Dihydroxyvitamin D3 rapidly increases cytosolic calcium in clonal rat osteosarcoma cells lacking the vitamin D Receptor
Daniel T. Baran, Ann Marie Sorensen, Victoria Shalhoub, Thomas A. Owen, Annette M. Oberdorf, Gary S. Stein, Jane B. Lian · 1991 · Journal of Bone and Mineral Research
Rapid Effects of Aldosterone and Spironolactone in the Isolated Working Rat Heart
John C. Barbato, Patrick J. Mulrow, Joseph I. Shapiro, Roberto Franco-Saenz · 2002 · Hypertension
Overexpression and mutations of p53 in metastatic malignant melanomas
Arndt Hartmann, Hagen Blaszyk, Julie S. Cunningham, Renee M. McGovern, Schroeder Jj, Steven D. Helander, Mark R. Pittelkow, Steve S. Sommer, John S. Kovach · 1996 · International Journal of Cancer
Nongenomic Inhibition of Catecholamine Secretion by 17β‐Estradiol in PC12 Cells
Youn‐Jae Kim, Eun‐Mi Hur, Tae‐Ju Park, Kyong‐Tai Kim · 2000 · Journal of Neurochemistry
Progesterone and cell–cell adhesion interact to regulate rat granulosa cell apoptosis
John J. Peluso, Anna Pappalardo · 1994 · Biochemistry and Cell Biology
Potentiation by thyroxine of interferon-gamma-induced antiviral state requires PKA and PKC activities
Hung‐Yun Lin, H. R. Thacorf, Faith B. Davis, Paul J. Davis · 1996 · American Journal of Physiology-Cell Physiology
Rapid 1,25(OH)2-vitamin D3 stimulation of calcium uptake by rat intestinal cells involves a dihydropyridine-sensitive cAMP-dependent pathway
Virginia Massheimer, Ricardo Boland, Ana R. de Boland · 1994 · Cellular Signalling
Genomic and Non-genomic Actions of Progesterone in the Control of Female Hamster Sexual Behavior
Joseph F. DeBold, Cheryl Anne Frye · 1994 · Hormones and Behavior
Androgen stimulates mitogen-activated protein kinase in human breast cancer cells
Xiang Zhu, He Li, Junping Liu, John W. Funder · 1999 · Molecular and Cellular Endocrinology
Binding characteristics of a membrane receptor that recognizes 1α25‐dihydroxyvitamin D3 and its epimer, 1β,25‐dihydroxyvitamin D3
Daniel T. Baran, Rahul Ray, Ann Marie Sorensen, Thomas W. Honeyman, Michael F. Holick · 1994 · Journal of Cellular Biochemistry
Possible role of Ca2+ channels in the vasodilating effect of 5β-dihydrotestosterone in rat aorta
Mercedes Perusquı́a, Carlos M. Villalón · 1999 · European Journal of Pharmacology
Voltage-operated Ca2+ channels and the acrosome reaction: which channels are present and what do they do?
Stephen John Publicover · 1999 · Human Reproduction
Reversal of Behavioral Effects of Pentylenetetrazol by the Neuroactive Steroid Ganaxolone
Marjolein Beekman, Jesse T. Ungard, Maciej Ga̧sior, Richard B. Carter, Durk Dijkstra, Steven R. Goldberg, Jeffrey M. Witkin · 1998 · Journal of Pharmacology and Experimental Therapeutics
Rapid Cardiovascular Action of Aldosterone in Man
Martin Wehling · 1998 · The Journal of Clinical Endocrinology & Metabolism
Nongenomic effects of progesterone on human intestinal smooth muscle cells
Klaus Bielefeldt, Laurie J. Waite, François M. Abboud, Jeffrey L. Conklin · 1996 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Non‐genomic effects of progesterone on the signaling function of G protein‐coupled receptors
Katja Bürger, Falk Fahrenholz, Gerald Gimpl · 1999 · FEBS Letters
Serotonergic Responses to Corticosterone and Testosterone in the Limbic System
Cliff H. Summers, Earl T. Larson, Patrick J. Ronan, Peter M. Hofmann, Aaron J. Emerson, Kenneth J. Renner · 2000 · General and Comparative Endocrinology
Electron microscopic visualization of membrane-mediated uptake and translocation of estrogen-BSA:colloidal gold by hep G2 cells
Moats RK, VD Ramirez · 2000 · Journal of Endocrinology
Chronic neurosteroid treatment prevents the development of morphine tolerance and attenuates abstinence behavior in mice
Doodipala Samba Reddy, Shrinivas K Kulkarni · 1997 · European Journal of Pharmacology
Nongenomic Effect of Glucocorticoid on the Release of Arginine Vasopressin from Hypothalamic Slices in Rats
Xiu Liu, Chun-An Wang, Yizhang Chen · 2008 · Neuroendocrinology
Non-genomic convergent and divergent signalling of rapid responses to aldosterone and estradiol in mammalian colon
Brian Joseph Harvey, Christina M. Doolan, Steven B. Condliffe, Céline Renard, Rodrigo Alzamora, Valérie Urbach · 2002 · Steroids
A novel functional estrogen receptor on human sperm membrane interferes with progesterone effects
Elisabetta Baldi, Michaela Luconi, Monica Muratori, Gianni Forti · 2000 · Molecular and Cellular Endocrinology
Nitric Oxide Synthesis Inhibitors Prevent Rapid Behavioral Effects of Corticosterone in Rats
Carmen Sandi, César Venero, Carmen Guaza · 2008 · Neuroendocrinology
Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone
Nataliya S. Kavok, Oksana A. Krasilnikova, Nataliya A. Babenko · 2001 · BMC Cell Biology
Rapid Effects of Aldosterone on Sodium-Hydrogen Exchange in Isolated Colonic Crypts
Winter Dc, G.C. O'Sullivan, Brian Joseph Harvey · 1999 · The Journal of Membrane Biology
Anxiolytic activity of steroid anesthetic alphaxalone.
K. Thatcher Britton, M. C. Page, Helen A. Baldwin, George F. Koob · 1991 · Journal of Pharmacology and Experimental Therapeutics
Nontranscriptional effects of steroid hormones.
Ilka Nemere, Zhou Lx, A W Norman · 1993 · PubMed
Specific Non-Genomic, Membrane-Localized Binding Sites for Progesterone in the Bovine Corpus Luteum1
Michael T. Rae, Garry S. Menzies, Alan S. McNeilly, Kathryn J. Woad, ROBERT WEBB, T. A. Bramley · 1998 · Biology of Reproduction
Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABAA receptors
Weixing Shen, Steven J. Mennerick, Erik C Zorumski, Douglas F. Covey, Charles F. Zorumski · 1999 · Neuropharmacology
Recurring themes in oocyte maturation
James L. Maller · 1998 · Biology of the Cell
Differing shapes of 1α,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: A status report
Anthony W. Norman, June E. Bishop, Elaine D. Collins, Eun‐Gyoung Seo, Donald P. Satchell, Murray C. Dormanen, Susana B. Zanello, Mary C. Farach‐Carson, Roger Bouillon, William H. Okamura · 1996 · The Journal of Steroid Biochemistry and Molecular Biology
Non-genomic actions of aldosterone: role in hypertension
John W. Funder · 2001 · Current Opinion in Nephrology & Hypertension
Effect of the neuropeptide substance P on the rat bone marrow-derived osteogenic cells in vitro
Maria Adamus, Zbigniew J. D browski · 2001 · Journal of Cellular Biochemistry
Size and steroid-binding characterization of membrane-associated glucocorticoid receptor in S-49 lymphoma cells
Bahiru Gametchu, Cheryl S. Watson, Dean Pasko · 1991 · Steroids
The Influence of Subchronic Administration of the Neurosteroid Allopregnanolone on Sleep in the Rat
K Damianisch · 2001 · Neuropsychopharmacology
Thyroid hormone therapy in cardiovascular disease
John D. Klemperer, Kaie Ojamaa, Irwin L. Klein · 1996 · Progress in Cardiovascular Diseases
Sigma receptor regulation of norepinephrine release from rat hippocampal slices
Grace M. Gonzalez‐Alvear, Linda L. Werling · 1995 · Brain Research
Endothelium-independent relaxation by 17-α-estradiol of pig coronary arteries
Eduardo Salas, Manuela G. López, Mércedes Villarroya, Pedro Sánchez‐García, Ricardo de Pascual, Walter R. Dixon, Antonio G. Garcı́a · 1994 · European Journal of Pharmacology
Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.
Hirohiko Kuratsune, K Yamaguti, MASAYOSHI SAWADA, S. Kodate, Takashi Machii, Y Kanakura, T Kitani · 1998 · International Journal of Molecular Medicine
Modulation by 1,25(OH)2-vitamin D3 of the adenylyl cyclase/cyclic AMP pathway in rat and chick myoblasts
Guillermo Vázquez, Ricardo Boland, Ana Russo de Boland · 1995 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Progesterone triggers rapid transmembrane calcium influx and/or calcium mobilization from endoplasmic reticulum, via a pertussis-insensitive G-protein in granulosa cells in relation to luteinization process
Véronique Machelon, Françoise Mercier‐Nomé, Brigitte Grosse, Michèle Lieberherr · 1996 · Journal of Cellular Biochemistry
Effects of physical endurance training on the plasma renin-angiotensin-aldosterone system in normal man
Peter Hespel, Paul J Lijnen, Roger Van Hoof, Robert H. Fagard, Willy Goossens, W. Lissens, E. J. Moerman, Antoon Amery · 1988 · Journal of Endocrinology
Neuroactive steroids and central nervous system disorders
Mingde Wang, Torbjörn Bäckström, Inger Sundström Poromaa, Göran Wahlström, Tommy Olsson, Di Zhu, Inga‐Maj Johansson, Inger Björn, Marie Bixo · 2001 · International review of neurobiology
The novel effects of 3,5,3′-triiodo-L-thyronine on myocyte contractile function and β-adrenergic responsiveness in dilated cardiomyopathy
Jennifer D. Walker, Fred A. Crawford, Satoshi Kato, Francis G. Spinale · 1994 · Journal of Thoracic and Cardiovascular Surgery
Progesterone Action in a Murine Leydig Tumor Cell Line (mLTC-1), Possibly through a Nonclassical Receptor Type1
Talal El‐Hefnawy, Pulak R. Manna, Michaela Luconi, Elizabetta Baldi, J. Peter Slotte, Ilpo Tapani Huhtaniemi · 2000 · Endocrinology
GAL4/UAS-WGA system as a powerful tool for tracingDrosophila transsynaptic neural pathways
Katsuhiko Tabuchi, Kazunobu Sawamoto, Emiko Suzuki, Koichi Ozaki, Masaki Sone, Chihiro Hama, Takako Morimoto-Tanifuji, Yoshihiro Yuasa, Yoshihiro Yoshihara, Akinao Nose et al. · 2000 · Journal of Neuroscience Research
Nongenomic progesterone receptor on human spermatozoa: biochemical aspects and clinical implications
Elisabetta Baldi · 1999 · Steroids
Aldosterone-specific membrane receptors and rapid non-genomic actions of mineralocorticoids
Martin Wehling, Christoph Eisen, Michael Christ · 1992 · Molecular and Cellular Endocrinology
Biphasic effects of sigma ligands on the neuronal response to N-methyl-D-aspartate
Richard Bergeron, Claude de Montigny, Guy Debonnel · 1995 · Naunyn-Schmiedeberg s Archives of Pharmacology
Characterization of high affinity progesterone-binding membrane proteins by an anti-peptide antiserum
Christiane Meyer, Roland Schmid, Kerstin Schmieding, Elisabeth Falkenstein, Martin Wehling · 1998 · Steroids
Nongenomic actions of the steroid hormone 1α25‐dihydroxyvitamin D3
Daniel T. Baran · 1994 · Journal of Cellular Biochemistry
Functional studies of corticosterone receptors in neuronal membranes.
Frank L. Moore, Miles Orchinik, Christopher A. Lowry · 1995 · PubMed
Progesterone Promotes Rapid Desensitization of α 1 -Adrenergic Receptor Augmentation of cAMP Formation in Rat Hypothalamic Slices
Nicolas Petitti, Anne M. Etgen · 2008 · Neuroendocrinology
σ1 Receptors in rat striatum regulate NMDA-stimulated [3H]dopamine release via a presynaptic mechanism
Grace M. Gonzalez‐Alvear, Linda L. Werling · 1995 · European Journal of Pharmacology
1,25(OH)2-Vitamin D3 stimulation of phospholipases C and D in muscle cells involves extracellular calcium and a pertussis-sensitive G protein
Susana Morelli, Ricardo Boland, Ana R. de Boland · 1996 · Molecular and Cellular Endocrinology
Induction of intracellular ceramide by interleukin-1β in oligodendrocytes
Alessandra Brogi, Michelina Strazza, Marialuisa Melli, Elvira Costantino‐Ceccarini · 1997 · Journal of Cellular Biochemistry
Membrane estrogen and glucocorticoid receptors—implications for hormonal control of immune function and autoimmunity
Cheryl S. Watson, Bahiru Gametchu · 2001 · International Immunopharmacology
An Immediate Increase in Calcium Accumulation by Rat Thymocytes Induced by Triiodothyronine: Its Role in the Subsequent Metabolic Responses*
Joseph Segal, Sidney H. Ingbar · 1984 · Endocrinology
Rapid accumulation of cyclic GMP near activated vitamin D receptors.
J Bársony, Stephen J. Marx · 1991 · Proceedings of the National Academy of Sciences
A Subset of Kappa Opioid Ligands Bind to the Membrane Glucocorticoid Receptor in an Amphibian Brain
Simon J. Evans, Brian T. Searcy, Frank L. Moore · 2000 · Endocrinology
Regulation of the metabolism of 1,2-diacyglycerols and inositol phasphates that respond to receptor activation
Stephen B. Shears · 1991 · Pharmacology & Therapeutics
Identification of functional binding sites for progesterone in rat Leydig cell plasma membrane
Marco Rossato · 1999 · Steroids
Steroid modulation of the strychnine-sensitive glycine receptor
Richard J. Prince, Michael A. Simmonds · 1992 · Neuropharmacology
Effect of progesterone and its 5 α and 5β metabolites on symptoms of premenstrual syndrome according to route of administration
W van Selow, Lorraine Dennerstein, Kenneth M. Greenwood, Bruno De Lignieres · 1996 · Journal of Psychosomatic Obstetrics & Gynecology
Evidence that nitric oxide synthase is involved in progesterone-induced acrosomal exocytosis in mouse spermatozoa
MB Herrero, J. Marcelo Viggiano, Silvina Pérez Martı́nez, M.F. Gimeno · 1997 · Reproduction Fertility and Development