Nongenomic steroid action: controversies, questions, and answers
Abstract
Lösel, Ralf M., Elisabeth Falkenstein, Martin Feuring, Armin Schultz, Hanns-Christian Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action: Controversies, Questions, and Answers. Physiol Rev 83: 965–1016, 2003; 10.1152/physrev.00003.2003.—Steroids may exert their action in living cells by several ways: 1) the well-known genomic pathway, involving hormone binding to cytosolic (classic) receptors and subsequent modulation of gene expression followed by protein synthesis. 2) Alternatively, pathways are operating that do not act on the genome, therefore indicating nongenomic action. Although it is comparatively easy to confirm the nongenomic nature of a particular phenomenon observed, e.g., by using inhibitors of transcription or translation, considerable controversy exists about the identity of receptors that mediate these responses. Many different approaches have been employed to answer this question, including pharmacology, knock-out animals, and numerous biochemical studies. Evidence is presented for and against both the participation of classic receptors, or proteins closely related to them, as well as for the involvement of yet poorly understood, novel membrane steroid receptors. In addition, clinical implications for a wide array of nongenomic steroid actions are outlined.
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Mammalian steroid hormones structurally related to phytoecdysteroids elicit rapid non-genomic signaling events that mediate cell proliferation and survival.
“In addition to classical nuclear receptor responses, mammalian steroid hormones that are structurally related to PEs have been known to elicit rapid non-genomic signaling events that mediate cell proliferation and survival.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [181]
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Nongenomic actions of steroid hormones
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“These responses may involve secondary signals such as altered Ca2+ or cAMP [5].”
BackgroundMolecular Cloning and Functional Characterization of a Zebrafish Nuclear Progesterone Receptor1
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- Authors
- LÖSEL, R. M., FALKENSTEIN, E., FEURING, M., SCHULTZ, A., TILLMANN, H.-C., ROSSOL-HASEROTH, K., & WEHLING, M.
- Affiliations
- Heidelberg University (DE)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2003-07
- Volume
- 83
- Issue
- 3
- Pages
- 965-1016
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2113893197
- Cited by
- 561
- References
- 562
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 15 · 2017: 17 · 2016: 20 · 2015: 23 · 2014: 22 · 2013: 23 · 2012: 31
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- non-genomic steroid action, steroid hormone receptors, membrane steroid receptors, cytosolic receptor, gene expression regulation, steroid pharmacology, knockout animals
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Receptors, Steroid, Steroids, Signal Transduction, Genome
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