Cited by 561Estrogen and related hormone effectsReceptor Mechanisms and SignalingAdrenal Hormones and Disorders

Nongenomic steroid action: controversies, questions, and answers

LÖSEL, RALF M., FALKENSTEIN, ELISABETH, FEURING, MARTIN, SCHULTZ, ARMIN, TILLMANN, HANNS-CHRISTIAN, ROSSOL-HASEROTH, KARIN, WEHLING, MARTIN·2003·Physiological Reviews

Abstract

Lösel, Ralf M., Elisabeth Falkenstein, Martin Feuring, Armin Schultz, Hanns-Christian Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action: Controversies, Questions, and Answers. Physiol Rev 83: 965–1016, 2003; 10.1152/physrev.00003.2003.—Steroids may exert their action in living cells by several ways: 1) the well-known genomic pathway, involving hormone binding to cytosolic (classic) receptors and subsequent modulation of gene expression followed by protein synthesis. 2) Alternatively, pathways are operating that do not act on the genome, therefore indicating nongenomic action. Although it is comparatively easy to confirm the nongenomic nature of a particular phenomenon observed, e.g., by using inhibitors of transcription or translation, considerable controversy exists about the identity of receptors that mediate these responses. Many different approaches have been employed to answer this question, including pharmacology, knock-out animals, and numerous biochemical studies. Evidence is presented for and against both the participation of classic receptors, or proteins closely related to them, as well as for the involvement of yet poorly understood, novel membrane steroid receptors. In addition, clinical implications for a wide array of nongenomic steroid actions are outlined.

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Crossref · 10.1152/physrev.00003.2003

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562 of 562 references verified0 citation errors · 0 not checkable

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  • Mammalian steroid hormones structurally related to phytoecdysteroids elicit rapid non-genomic signaling events that mediate cell proliferation and survival.

    “In addition to classical nuclear receptor responses, mammalian steroid hormones that are structurally related to PEs have been known to elicit rapid non-genomic signaling events that mediate cell proliferation and survival.”

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Authors
LÖSEL, R. M., FALKENSTEIN, E., FEURING, M., SCHULTZ, A., TILLMANN, H.-C., ROSSOL-HASEROTH, K., & WEHLING, M.
Affiliations
Heidelberg University (DE)
Venue
Physiological Reviews
Published
2003-07
Volume
83
Issue
3
Pages
965-1016
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
OpenAlex
W2113893197
Cited by
561
References
562
Citations by year
2026: 3 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 15 · 2017: 17 · 2016: 20 · 2015: 23 · 2014: 22 · 2013: 23 · 2012: 31
FWCI
4.72
Type
journal article
Language
en
Open access
closed
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
non-genomic steroid action, steroid hormone receptors, membrane steroid receptors, cytosolic receptor, gene expression regulation, steroid pharmacology, knockout animals
MeSH terms
Animals, Gene Expression Regulation, Humans, Receptors, Steroid, Steroids, Signal Transduction, Genome

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