The DOI matches its Crossref record; 418 of the 418 references it cites were found in a registry or an index.
Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development
Abstract
Spermatogenesis is an intriguing but complicated biological process. However, many studies since the 1960s have focused either on the hormonal events of the hypothalamus-pituitary-testicular axis or morphological events that take place in the seminiferous epithelium. Recent advances in biochemistry, cell biology, and molecular biology have shifted attention to understanding some of the key events that regulate spermatogenesis, such as germ cell apoptosis, cell cycle regulation, Sertoli-germ cell communication, and junction dynamics. In this review, we discuss the physiology and biology of junction dynamics in the testis, in particular how these events affect interactions of Sertoli and germ cells in the seminiferous epithelium behind the blood-testis barrier. We also discuss how these events regulate the opening and closing of the blood-testis barrier to permit the timely passage of preleptotene and leptotene spermatocytes across the blood-testis barrier. This is physiologically important since developing germ cells must translocate across the blood-testis barrier as well as traverse the seminiferous epithelium during their development. We also discuss several available in vitro and in vivo models that can be used to study Sertoli-germ cell anchoring junctions and Sertoli-Sertoli tight junctions. An in-depth survey in this subject has also identified several potential targets to be tackled to perturb spermatogenesis, which will likely lead to the development of novel male contraceptives.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Items 401–418 of 418
Sertolin Is a Novel Gene Marker of Cell-Cell Interactions in the Rat Testis
Mruk, D. D., & Cheng, C. Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.27056 · Cited by 45
Self-citationEl-Bahrawy, M. A., & Pignatelli, M. (1998) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19981101)43:3<224::aid-jemt4>3.0.co;2-q · Cited by 44
Evidence for Cross‐Talk Between Sertoli and Germ Cells Using Selected Cathepsins as Markers
Chung, S. S. W., Zhu, L.-J., Mo, M., Silvestrini, B., Lee, W. M., & Cheng, C. Y. (1998) · Journal of Andrology · doi:10.1002/j.1939-4640.1998.tb02078.x · Cited by 43
Self-citationMruk, D. D., Cheng, C.-H., Cheng, Y.-H., Mo, M., Grima, J., Silvestrini, B., Lee, W. M., & Cheng, C. Y. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.2.298 · Cited by 39
Self-citationMiller, A. T., Picton, H. M., Craigon, J., et al. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.6.1372 · Cited by 35
Germ cell control of testin production is inverse to that of other Sertoli cell products
Jégou, B., Pineau, C., de la Calle, J. F. V., Touzalin, A.-M., Bardin, C. W., & Cheng, C. Y. (1993) · Endocrinology · doi:10.1210/en.132.6.2557 · Cited by 34
Self-citationTestins are Localized to the Junctional Complexes of Rat Sertoli and Epididymal Cells1
Zong, S. D., Bardin, C. W., Phillips, D., & Cheng, C. Y. (1992) · Biology of Reproduction · doi:10.1095/biolreprod47.4.568 · Cited by 33
Self-citationLynch, R. D., Tkachuk-Ross, L. J., McCormack, J. M., McCarthy, K. M., Rogers, R. A., & Schneeberger, E. E. (1995) · PubMed · Cited by 32
Sertoli cell binding to isolated testicular basement membrane.
Enders, G. C., Henson, J., & Millette, C. F. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.3.1109 · Cited by 30
The Tight Junctions in the Testis, Epididymis, and Vas Deferens
Pelletier, R. ‐. (2001) · CRC Press eBooks · doi:10.1201/9781420038538.ch28 · Cited by 29
Nilsson, M., Fagman, H., & Ericson, L. E. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0151 · Cited by 28
Changes of Energy Metabolism in the Germ Cells and Ehrlich Ascites Tumor Cells
Floridi, A., BELLOCCI, M., Paggi, M. G., Marcante, M. L., & Martino, C. D. (2009) · Chemotherapy · doi:10.1159/000238045 · Cited by 28
Zwain, I. H., Grima, J., Stahler, M. S., Saso, L., Ćailleau, J., Verhoeven, G., Bardin, C. W., & Cheng, C. Y. (1993) · Biology of Reproduction · doi:10.1095/biolreprod48.1.180 · Cited by 28
Self-citationFloridi, A., DeMartino, C., Marcante, M. L., Apollonj, C., Barcellona, P. S., & Silvestrini, B. (1981) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(81)90015-0 · Cited by 27
Expanding Role of G Proteins in Tight Junction Regulation: Gαs Stimulates TJ Assembly
Saha, C., Nigám, S. K., & Denker, B. M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5154 · Cited by 26
Braghiroli, L., Silvestrini, B., Sorrentino, C., Grima, J., Mruk, D., & Cheng, C.-Y. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.1.111 · Cited by 20
Self-citationChardin, P. (1999) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-58591-3_3 · Cited by 18
Interaction of Androgens and Oestrogens in Development of the Testis and Male Reproductive Tract
Sharpe, R. M., McKinnell, C., Atanassova, N. N., Williams, K., Turner, K. J., Saunders, P. T. K., Walker, M., Millar, M. R., & Fisher, J. S. (2000) · Springer eBooks · doi:10.1007/978-3-662-04050-8_12 · Cited by 15
Cited by
The testis in immune privilege
Fijak, M., & Meinhardt, A. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00438.x · Cited by 483
The Immunoglobulin-Like Cell Adhesion Molecule Nectin and Its Associated Protein Afadin
Takai, Y., Ikeda, W., Ogita, H., & Rikitake, Y. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175339 · Cited by 371
Pembrey, M., Saffery, R., Bygren, L. O., & Network in Epigenetic Epidemiology (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102577 · Cited by 325
Immunological, paracrine and endocrine aspects of testicular immune privilege
Meinhardt, A., & Hedger, M. P. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.03.022 · Cited by 262
The Gut Microbiota and Developmental Programming of the Testis in Mice
Al-Asmakh, M., Stukenborg, J.-B., Reda, A., Anuar, F., Strand, M.-L., Hedin, L., Pettersson, S., & Söder, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103809 · Cited by 173
“ZO-2 and ZO-3) [5] and effectively restrict paracellular passage of”
BackgroundInfluential
Metadata
- Authors
- Cheng, C. Y., & Mruk, D. D.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2002-01-10
- Volume
- 82
- Issue
- 4
- Pages
- 825-874
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2145562458
- Cited by
- 567
- References
- 418
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
