Cited by 282

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Physiology and Pathophysiology of Itch

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Cevikbas, Ferda, Lerner, Ethan A.·2020·Physiological Reviews

DOI 10.1152/physrev.00017.2019

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Abstract

Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly understood and appreciated. The pathophysiological consequences of itch impact quality of life as much as pain. These dynamics have led to increasingly deep dives into the mechanisms that underlie and contribute to the sensation of itch. When the prior review on the physiology of itching was published in this journal in 1941, itch was a black box of interest to a small number of neuroscientists and dermatologists. Itch is now appreciated as a complex and colorful Rubik’s cube. Acute and chronic itch are being carefully scratched apart and reassembled by puzzle solvers across the biomedical spectrum. New mediators are being identified. Mechanisms blur boundaries of the circuitry that blend neuroscience and immunology. Measures involve psychophysics and behavioral psychology. The efforts associated with these approaches are positively impacting the care of itchy patients. There is now the potential to markedly alleviate chronic itch, a condition that does not end life, but often ruins it. We review the itch field and provide a current understanding of the pathophysiology of itch. Itch is a disease, not only a symptom of disease.

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Kremer, A. E., Gonzales, E. M., Schaap, F. G., Elferink, R. P. J. O., Jacquemin, E., & Beuers, U. H. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001044 · Cited by 32
Regulation of substance P mRNA expression in human dermal microvascular endothelial cells.
Milner, P., Bodin, P., Guiducci, S., Rosso, A. D., Kahaleh, M. B., Matucci‐Cerinic, M., & Burnstock, G. (2004) · PubMed · Cited by 29
Prostanoids in allergy
Honda, T., & Kabashima, K. (2014) · Allergology International · doi:10.1016/j.alit.2014.08.002 · Cited by 28
Role of histamine H 4 receptor ligands in bleomycin-induced pulmonary fibrosis
Lucarini, L., Pini, A., Rosa, A. C., Lanzi, C., Durante, M., Chazot, P. L., Krief, S., Schreeb, A., Stark, H., & Masini, E. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.07.037 · Cited by 22
Spinal dorsal horn astrocytes: New players in chronic itch
Tsuda, M. (2016) · Allergology International · doi:10.1016/j.alit.2016.07.007 · Cited by 22
Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase-Activated Receptor-4 in Mice
Patrício, E. D. S., da Costa, R., Figueiredo, C. P., Gers‐Barlag, K., Bicca, M. A., Manjavachi, M. N., Segat, G. C., Gentry, C., Luiz, A. P., Fernandes, E. S., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.183 · Cited by 20
Methods for Preclinical Assessment of Antipruritic Agents and Itch Mechanisms Independent of Mast-Cell Histamine
Kuraishi, Y. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00090 · Cited by 20
Topical Aprepitant in Clinical and Experimental Pruritus
Wallengren, J. (2012) · Archives of Dermatology · doi:10.1001/archdermatol.2012.1018 · Cited by 20
Astrocytes in the spinal dorsal horn and chronic itch
Tsuda, M. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.08.010 · Cited by 20
Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice
Nocchi, L., Roy, N., D’Attilia, M., Dhandapani, R., Maffei, M., Traista, A., Castaldi, L., Perlas, E., Chadick, C. H., & Heppenstall, P. A. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0328-5 · Cited by 20
Many parallels between itch and pain research
Carstens, E. (2015) · European Journal of Pain · doi:10.1002/ejp.778 · Cited by 16
Glial Cells are Involved in Itch Processing
Andersen, H. H., Arendt‐Nielsen, L., & Gazerani, P. (2014) · Acta Dermato Venereologica · doi:10.2340/00015555-2366 · Cited by 15
Bombesin—a central mediator of pruritus?
Gmerek, D. E., & Cowan, A. (1983) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1983.tb07091.x · Cited by 14
Generation of a NK1R‐CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling
Huang, H., Kuzirian, M. S., Cai, X., Snyder, L. M., Cohen, J. A., Kaplan, D. H., & Ross, S. E. (2016) · genesis · doi:10.1002/dvg.22985 · Cited by 13
Misexpression of Ptf1a in Cortical Pyramidal CellsIn VivoPromotes an Inhibitory Peptidergic Identity
Russ, J. B., Borromeo, M. D., Kollipara, R. K., Bommareddy, P. K., Johnson, J. E. B., & Kaltschmidt, J. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3821-14.2015 · Cited by 10
Strongyloidiasis in the immunocompetent: an overlooked infection
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Are itch and scratching the nausea and vomiting of skin?
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Self-citation

Peripheral itch sensitization in atopic dermatitis
Tominaga, M., & Takamori, K. (2022) · Allergology International · doi:10.1016/j.alit.2022.04.003 · Cited by 160
Itch in Atopic Dermatitis – What Is New?
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Expectancies and avoidance: Towards an integrated model of chronic somatic symptoms
Nadinda, P. G., van Laarhoven, A. I. M., Van den Bergh, O., Vlaeyen, J. W. S., Peters, M. L., & Evers, A. W. M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105808 · Cited by 15

See all 282

Authors: Cevikbas, F., & Lerner, E. A.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2020-07-01
Volume: 100
Issue: 3
Pages: 945-982
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00017.2019
OpenAlex: W2997548580
Cited by: 282
References: 302
FWCI: 5.98
Type: journal article
Language: en
Open access: green

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Physiology and Pathophysiology of Itch

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