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Cited by 355

The DOI matches its Crossref record; 246 of the 246 references it cites were found in a registry or an index.

Role of the Gut in Lipid Homeostasis

Open access
Abumrad, Nada A., Davidson, Nicholas O.·2012·Physiological Reviews
DOI 10.1152/physrev.00019.2011
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Abstract

Intestinal lipid transport plays a central role in fat homeostasis. Here we review the pathways regulating intestinal absorption and delivery of dietary and biliary lipid substrates, principally long-chain fatty acid, cholesterol, and other sterols. We discuss the regulation and functions of CD36 in fatty acid absorption, NPC1L1 in cholesterol absorption, as well as other lipid transporters including FATP4 and SRB1. We discuss the pathways of intestinal sterol efflux via ABCG5/G8 and ABCA1 as well as the role of the small intestine in high-density lipoprotein (HDL) biogenesis and reverse cholesterol transport. We review the pathways and genetic regulation of chylomicron assembly, the role of dominant restriction points such as microsomal triglyceride transfer protein and apolipoprotein B, and the role of CD36, l-FABP, and other proteins in formation of the prechylomicron complex. We will summarize current concepts of regulated lipoprotein secretion (including HDL and chylomicron pathways) and include lessons learned from families with genetic mutations in dominant pathways (i.e., abetalipoproteinemia, chylomicron retention disease, and familial hypobetalipoproteinemia). Finally, we will provide an integrative view of intestinal lipid homeostasis through recent findings on the role of lipid flux and fatty acid signaling via diverse receptor pathways in regulating absorption and production of satiety factors.

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Citations

Cites

1 retracted

Items 201–246 of 246

Research works printed but not linked: 18

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Metadata

Authors
Abumrad, N. A., & Davidson, N. O.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2012-07
Volume
92
Issue
3
Pages
1061-1085
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00019.2011
OpenAlex
W2129202635
Cited by
355
References
246
FWCI
7.14
Type
journal article
Language
en
Open access
green

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