The DOI matches its Crossref record; 368 of the 368 references it cites were found in a registry or an index.
Free Fatty Acid Receptors in Health and Disease
Open accessAbstract
Fatty acids are metabolized and synthesized as energy substrates during biological responses. Long- and medium-chain fatty acids derived mainly from dietary triglycerides, and short-chain fatty acids (SCFAs) produced by gut microbial fermentation of the otherwise indigestible dietary fiber, constitute the major sources of free fatty acids (FFAs) in the metabolic network. Recently, increasing evidence indicates that FFAs serve not only as energy sources but also as natural ligands for a group of orphan G protein-coupled receptors (GPCRs) termed free fatty acid receptors (FFARs), essentially intertwining metabolism and immunity in multiple ways, such as via inflammation regulation and secretion of peptide hormones. To date, several FFARs that are activated by the FFAs of various chain lengths have been identified and characterized. In particular, FFAR1 (GPR40) and FFAR4 (GPR120) are activated by long-chain saturated and unsaturated fatty acids, while FFAR3 (GPR41) and FFAR2 (GPR43) are activated by SCFAs, mainly acetate, butyrate, and propionate. In this review, we discuss the recent reports on the key physiological functions of the FFAR-mediated signaling transduction pathways in the regulation of metabolism and immune responses. We also attempt to reveal future research opportunities for developing therapeutics for metabolic and immune disorders.
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Cites
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Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442
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Metadata
- Authors
- Kimura, I., Ichimura, A., Ohue-Kitano, R., & Igarashi, M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2020-01-01
- Volume
- 100
- Issue
- 1
- Pages
- 171-210
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2971877727
- Cited by
- 1,018
- References
- 368
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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