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Cited by 420

The DOI matches its Crossref record; 383 of the 383 references it cites were found in a registry or an index.

Transient Receptor Potential Channels in the Vasculature

Open access
Earley, Scott, Brayden, Joseph E.·2015·Physiological Reviews
DOI 10.1152/physrev.00026.2014
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Abstract

The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species. Multiple TRP channels are present in all cells and are involved in diverse aspects of cellular function, including sensory perception and signal transduction. Notably, TRP channels are involved in regulating vascular function and pathophysiology, the focus of this review. TRP channels in vascular smooth muscle cells participate in regulating contractility and proliferation, whereas endothelial TRP channel activity is an important contributor to endothelium-dependent vasodilation, vascular wall permeability, and angiogenesis. TRP channels are also present in perivascular sensory neurons and astrocytic endfeet proximal to cerebral arterioles, where they participate in the regulation of vascular tone. Almost all of these functions are mediated by changes in global intracellular Ca 2+levels or subcellular Ca 2+signaling events. In addition to directly mediating Ca 2+entry, TRP channels influence intracellular Ca 2+dynamics through membrane depolarization associated with the influx of cations or through receptor- or store-operated mechanisms. Dysregulation of TRP channels is associated with vascular-related pathologies, including hypertension, neointimal injury, ischemia-reperfusion injury, pulmonary edema, and neurogenic inflammation. In this review, we briefly consider general aspects of TRP channel biology and provide an in-depth discussion of the functions of TRP channels in vascular smooth muscle cells, endothelial cells, and perivascular cells under normal and pathophysiological conditions.

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Metadata

Authors
Earley, S., & Brayden, J. E.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2015-04
Volume
95
Issue
2
Pages
645-690
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00026.2014
OpenAlex
W2117597411
Cited by
420
References
383
FWCI
4.38
Type
journal article
Language
en
Open access
green

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