Cited by 273Cellular Mechanics and InteractionsElasticity and Material ModelingCell Adhesion Molecules Research

Vascular mechanotransduction

Open access
Davis, Michael J., Earley, Scott, Li, Yi-Shuan, Chien, Shu·2023·Physiological Reviews

Abstract

This review aims to survey the current state of mechanotransduction in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical stimuli and transduction of mechanical signals that result in the acute functional modulation and longer-term transcriptomic and epigenetic regulation of blood vessels. The mechanosensors discussed include ion channels, plasma membrane-associated structures and receptors, and junction proteins. The mechanosignaling pathways presented include the cytoskeleton, integrins, extracellular matrix, and intracellular signaling molecules. These are followed by discussions on mechanical regulation of transcriptome and epigenetics, relevance of mechanotransduction to health and disease, and interactions between VSMCs and ECs. Throughout this review, we offer suggestions for specific topics that require further understanding. In the closing section on conclusions and perspectives, we summarize what is known and point out the need to treat the vasculature as a system, including not only VSMCs and ECs but also the extracellular matrix and other types of cells such as resident macrophages and pericytes, so that we can fully understand the physiology and pathophysiology of the blood vessel as a whole, thus enhancing the comprehension, diagnosis, treatment, and prevention of vascular diseases.

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Crossref · 10.1152/physrev.00053.2021

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1847 of 1847 references verified0 citation errors · 0 not checkable

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  • Smooth muscle cells give elasticity and contractility to vascular grafts in media layer and secrete extracellular matrix to stabilize vascular structure.

    “Smooth muscle cells give elasticity and contractility to vascular grafts in the media layer of vascular grafts, while secreting extracellular matrix to stabilize vascular structure [160].”

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Authors
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S.
Affiliations
  • University of Missouri (US)
  • University of Nevada, Reno (US)
  • University of California San Diego (US)
Corresponding author
  • Davis, Michael J.
  • Chien, Shu
Venue
Physiological Reviews
Published
2023-04-01
Volume
103
Issue
2
Pages
1247-1421
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
OpenAlex
W4313554974
Cited by
273
References
1,844
Citations by year
2026: 101 · 2025: 80 · 2024: 66 · 2023: 25 · 2022: 1
FWCI
8.83
Type
journal article
Language
en
Open access
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • HHS | NIH | National Heart, Lung, and Blood Institute (HL122578, HL106579, HL108735, HL121365, HL155008, R35HL155008)
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (RF1NS110044)
  • HHS | NIH | National Institute of General Medical Sciences (P20GM130459)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
vascular smooth muscle cells, endothelial cells, mechanosensors, ion channels, cytoskeleton, integrins, extracellular matrix, transcriptome regulation, epigenetic regulation, vascular disease, pericytes, macrophages
MeSH terms
Humans, Stress, Mechanical, Signal Transduction, Myocytes, Smooth Muscle, Mechanotransduction, Cellular, Endothelial Cells, Epigenesis, Genetic

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