Vascular mechanotransduction
Open accessAbstract
This review aims to survey the current state of mechanotransduction in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical stimuli and transduction of mechanical signals that result in the acute functional modulation and longer-term transcriptomic and epigenetic regulation of blood vessels. The mechanosensors discussed include ion channels, plasma membrane-associated structures and receptors, and junction proteins. The mechanosignaling pathways presented include the cytoskeleton, integrins, extracellular matrix, and intracellular signaling molecules. These are followed by discussions on mechanical regulation of transcriptome and epigenetics, relevance of mechanotransduction to health and disease, and interactions between VSMCs and ECs. Throughout this review, we offer suggestions for specific topics that require further understanding. In the closing section on conclusions and perspectives, we summarize what is known and point out the need to treat the vasculature as a system, including not only VSMCs and ECs but also the extracellular matrix and other types of cells such as resident macrophages and pericytes, so that we can fully understand the physiology and pathophysiology of the blood vessel as a whole, thus enhancing the comprehension, diagnosis, treatment, and prevention of vascular diseases.
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Smooth muscle cells give elasticity and contractility to vascular grafts in media layer and secrete extracellular matrix to stabilize vascular structure.
“Smooth muscle cells give elasticity and contractility to vascular grafts in the media layer of vascular grafts, while secreting extracellular matrix to stabilize vascular structure [160].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [160]
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- Authors
- Davis, M. J., Earley, S., Li, Y.-S., & Chien, S.
- Affiliations
- University of Missouri (US)
- University of Nevada, Reno (US)
- University of California San Diego (US)
- Corresponding author
- Davis, Michael J.
- Chien, Shu
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2023-04-01
- Volume
- 103
- Issue
- 2
- Pages
- 1247-1421
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC9942936
- OpenAlex
- W4313554974
- Cited by
- 273
- References
- 1,844
- Citations by year
- 2026: 101 · 2025: 80 · 2024: 66 · 2023: 25 · 2022: 1
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Heart, Lung, and Blood Institute (HL122578, HL106579, HL108735, HL121365, HL155008, R35HL155008)
- HHS | NIH | National Institute of Neurological Disorders and Stroke (RF1NS110044)
- HHS | NIH | National Institute of General Medical Sciences (P20GM130459)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- vascular smooth muscle cells, endothelial cells, mechanosensors, ion channels, cytoskeleton, integrins, extracellular matrix, transcriptome regulation, epigenetic regulation, vascular disease, pericytes, macrophages
- MeSH terms
- Humans, Stress, Mechanical, Signal Transduction, Myocytes, Smooth Muscle, Mechanotransduction, Cellular, Endothelial Cells, Epigenesis, Genetic
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