The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Renal Vacuolar H+-ATPase
Abstract
Vacuolar H+-ATPases are ubiquitous multisubunit complexes mediating the ATP-dependent transport of protons. In addition to their role in acidifying the lumen of various intracellular organelles, vacuolar H+-ATPases fulfill special tasks in the kidney. Vacuolar H+-ATPases are expressed in the plasma membrane in the kidney almost along the entire length of the nephron with apical and/or basolateral localization patterns. In the proximal tubule, a high number of vacuolar H+-ATPases are also found in endosomes, which are acidified by the pump. In addition, vacuolar H+-ATPases contribute to proximal tubular bicarbonate reabsorption. The importance in final urinary acidification along the collecting system is highlighted by monogenic defects in two subunits (ATP6V0A4, ATP6V1B1) of the vacuolar H+-ATPase in patients with distal renal tubular acidosis. The activity of vacuolar H+-ATPases is tightly regulated by a variety of factors such as the acid-base or electrolyte status. This regulation is at least in part mediated by various hormones and protein-protein interactions between regulatory proteins and multiple subunits of the pump.
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Cites
Molecular Mechanisms of Human Hypertension
Lifton, R. P., Gharavi, A. G., & Geller, D. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00241-0 · Cited by 1,686
Nongenomic actions of steroid hormones
Lösel, R., & Wehling, M. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1009 · Cited by 980
Davis, C. G., Goldstein, J. L., Südhof, T. C., Anderson, R. G. W., Russell, D. W., & Brown, M. S. (1987) · Nature · doi:10.1038/326760a0 · Cited by 411
Localization and function of angiotensin AT1 receptors.
ALLEN, A. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00249-6 · Cited by 278
Cited by
Large-scale proteomics and phosphoproteomics of urinary exosomes
Gonzales, P. A., Pisitkun, T., Hoffert, J. D., Tchapyjnikov, D., Star, R. A., Kleta, R., Wang, N. S., & Knepper, M. A. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008040406 · Cited by 727
Dubaissi, E., & Papalopulu, N. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.006494 · Cited by 102
Metadata
- Authors
- Wagner, C. A., Finberg, K. E., Breton, S., Marshansky, V., Brown, D., & Geibel, J. P.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2004-10
- Volume
- 84
- Issue
- 4
- Pages
- 1263-1314
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2165743932
- Cited by
- 443
- References
- 4
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
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